Hospital admissions for pneumonia more likely with concomitant dental infections

Laurence, Brian; Mould‐Millman, Nee‐Kofi; Scannapieco, Frank A.; Abron, Armin

doi:10.1007/s00784-014-1342-y

Cited by 26 publications

(17 citation statements)

References 26 publications

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“…Periodontal diseases and oral bacteria are associated with many systemic diseases and conditions, including coronary artery disease, rheumatoid arthritis, diabetes, pulmonary diseases, cancers of the oro-digestive tract, and Alzheimer's disease. [6][7][8][9][10][11] Therefore, prevention and treatment of periodontitis is important for oral and overall health of adults. Chronic periodontitis results from a breakdown in the homeostasis between the periodontal tissue and the surrounding microbes, subsequently leading to uncontrolled inflammation and tissue destruction.…”

Section: Introductionmentioning

confidence: 99%

Characterization and development of SAPP as a specific peptidic inhibitor that targets Porphyromonas gingivalis

Lamont

Chazin

et al. 2018

Molecular Oral Microbiology

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SUMMARY Porphyromonas gingivalis is a keystone bacterium in the oral microbial communities that elicits a dysbiosis between the microbiota and the host. Therefore, inhibition of this organism in dental plaques has been one of strategies for preventing and treating chronic periodontitis. We previously identified a Streptococcal ArcA derived Anti-P. gingivalils Peptide (SAPP) that in vitro, is capable of repressing the expression of several virulence genes in the organism. This leads to a significant reduction in P. gingivalis virulence potential, including its ability to colonize on the surface of Streptococcus gordonii, to invade human oral epithelial cells, and to produce gingipains. In this study, we showed that SAPP had minimal cytotoxicity to human oral keratinocytes and gingival fibroblasts. We observed that SAPP directly bound to the cell surface of P. gingivalis, and that alterations in the sequence at the N-terminus of SAPP diminished its abilities to interact with P. gingivalis cells and repressed the expression of virulence genes. Most strikingly, we demonstrated using an ex-vivo assay that besides its inhibitory activity against P. gingivalis colonization, SAPP could also reduce the levels of several other oral Gram-negative bacteria strongly associated with periodontitis in multispecies biofilms. Our results provide a platform for the development of SAPP-targeted therapeutics against chronic periodontitis.

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Section: Introductionmentioning

confidence: 99%

Characterization and development of SAPP as a specific peptidic inhibitor that targets Porphyromonas gingivalis

Lamont

Chazin

et al. 2018

Molecular Oral Microbiology

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“…For example, loss of self-esteem is associated with loss of teeth (40) and with untreated disease, such as periodontitis (40,44). Finally, periodontal disease is associated with several systemic diseases and conditions (9,11), such as diabetes (10,12,45), cardiovascular diseases (50,71,86,90), pulmonary diseases (55,57,73,91), rheumatoid arthritis (21,89), cognitive impairment/Alzheimer's disease (42,48,74,78), as well as cancers of the oro-digestive tract (oral cavity, gastrointestinal tract, bladder, liver, kidney and pancreas) (2,3,6,47,72). Whether the "golden" years at the end of the life cycle are lived in a healthy, enjoyable and productive style depends, in part, on the oral health status.…”

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confidence: 99%

Periodontitis prevalence in adults ≥ 65 years of age, in the USA

Eke¹,

Liang²,

Borgnakke³

et al. 2016

Periodontology 2000

262

220

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The older adult population is growing rapidly in the USA and it is expected that by 2040 the number of adults ≥ 65 years of age will have increased by about 50%. With the growth of this subpopulation, oral health status, and periodontal status in particular, becomes important in the quest to maintain an adequate quality of life. Poor oral health can have a major impact, leading to tooth loss, pain and discomfort, and may prevent older adults from chewing food properly, often leading to poor nutrition. Periodontitis is monitored in the USA at the national level as part of the Healthy People 2020 initiative. In this report, we provide estimates of the overall burden of periodontitis among adults ≥ 65 years of age and after stratification according to sociodemographic factors, modifiable risk factors (such as smoking status), the presence of other systemic conditions (such as diabetes) and access to dental care. We also estimated the burden of periodontitis within this age group at the state and local levels. Data from the National Health and Nutrition Examination Survey 2009/2010 and 2011/2012 cycles were analyzed. Periodontal measures from both survey cycles were based on a full-mouth periodontal examination. Nineteen per cent of adults in this subpopulation were edentulous. The mean age was 73 years, 7% were current smokers, 8% lived below the 100% Federal Poverty Level and < 40% had seen a dentist in the past year. Almost two-thirds (62.3%) had one or more sites with ≥ 5 mm of clinical attachment loss and almost half had at least one site with probing pocket depth of ≥ 4 mm. We estimated the lowest prevalence of periodontitis in Utah (62.3%) and New Hampshire (62.6%) and the highest in New Mexico, Hawaii, and the District of Columbia each with a prevalence of higher than 70%. Overall, periodontitis is highly prevalent in this subpopulation, with two-thirds of dentate older adults affected at any geographic level. These findings provide an opportunity to determine how the overall health-care management of older adults should consider the improvement of their oral health conditions. Many older adults do not have dental insurance and are also likely to have some chronic conditions, which can adversely affect their oral health.

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“…Depression is predictive of increased mortality among patients with cancer and the effect remains after adjusting for clinical comorbidities . In previous analyses, we demonstrated associations between the presence of dental infection and an increased likelihood of hospital admission among adult patients with sickle cell disease and among adult patients with pneumonia . As the incidence of HNC increases with age, especially after age 50, the aim of this study was to determine whether the presence of depression was associated with an increased likelihood of hospital admission among adult patients 50 years and over diagnosed with HNC visiting emergency departments (EDs) in the United States .…”

Section: Introductionmentioning

confidence: 99%

Depression and hospital admission in older patients with head and neck cancer: analysis of a national healthcare database

et al. 2016

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Hospital admissions for pneumonia more likely with concomitant dental infections

Abstract: The findings suggest that an increased focus on preventive oral health may reduce the need for admission following an ED visit for patients diagnosed with pneumonia.

Cited by 26 publications

References 26 publications

Characterization and development of SAPP as a specific peptidic inhibitor that targets Porphyromonas gingivalis

Characterization and development of SAPP as a specific peptidic inhibitor that targets Porphyromonas gingivalis

Periodontitis prevalence in adults ≥ 65 years of age, in the USA

Depression and hospital admission in older patients with head and neck cancer: analysis of a national healthcare database

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