Hospital related hyperglycemia as a predictor of mortality in non-diabetes patients: A systematic review

Pratiwi, Chici; Zulkifly, Steven; Dahlan, Tasha Farhana; Hafidzati, Adlina; Oktavia, Nani; Mokoagow, Muhammad Ikhsan; Epriliawati, Marina; Nasarudin, Jerry; Kshanti, Ida Ayu Made

doi:10.1016/j.dsx.2021.102309

Cited by 5 publications

(2 citation statements)

References 18 publications

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“… 16 It is well known that high blood glucose levels are associated with poor outcomes in both diabetics and non-diabetics, and is a biomarker of critical illness in patients admitted to the ICU. 17 - 20 Farooq et al 19 shown that hyperglycemia diagnosed during hospitalization is indicative of poor clinical outcomes and is associated with high mortality and morbidity. We found that the glucose value measured during admission to the ICU did not affect mortality.…”

Section: Discussionmentioning

confidence: 99%

Effect of cortisol and glycosylated-hemoglobin levels on mortality in intensive care unit

Sen,

Uzun,

Aydin

et al. 2024

SMJ

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Section: Discussionmentioning

confidence: 99%

Effect of cortisol and glycosylated-hemoglobin levels on mortality in intensive care unit

Sen,

Uzun,

Aydin

et al. 2024

SMJ

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“…This sustained exposure to high blood glucose levels may potentially weaken the correlation between hyperglycemia and mortality. [21][22][23] .…”

Section: Disussionmentioning

confidence: 99%

Nonlinear Relationship Between Blood Glucose and 28-day Mortality in Critically Ill Patients with Atrial Fibrillation

Zhang,

Liu,

Zhang

et al. 2023

Preprint

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Epidemiological studies have revealed a correlation between diabetes mellitus and elevated blood glucose levels with atrial fibrillation (AF). Blood glucose levels were assessed in critically ill atrial fibrillation patients to determine whether they correlate with 28-day mortality. This study incorporated a cohort of 13,105 critically ill patients diagnosed with AF from MIMIC-IV database. Both smooth curve analysis and cox proportional hazards regression were employed. The selected participants had a mean age of 73.7 ± 11.7 years, with an estimated 58.6% being male. Smooth curve regression showed that minimum glucose, maximum glucose followed non-linear curves with respect to 28-day all-cause mortality. The inflection points were 65 mg/dL and 166 mg/dL for minimum glucose and maximum glucose, respectively. There was a decreased risk of 28-day mortality observed with minimum glucose < 65 mg/dL (HR = 0.967, 95%CI 0.951 ~ 0.983, P < 0.001) and an increased mortality risk observed with it ≥ 65 mg/dL (HR = 1.007, 95%CI 1.005 ~ 1.009, P < 0.001). Increased maximum glucose contributed to lower risks of mortality when maximum glucose < 166 mg/dL (HR = 0.996, 95%CI 0.993 ~ 0.999, P = 0.012). However, there was no statistically significant correlation between an increase in glucose level and mortality (HR = 1.000, 95%CI 0.999 ~ 1.001, P = 0.511) among patients with a maximum glucose level of ≥ 166 mg/dL. These findings suggested that there exists a U-shaped association between minimum glucose levels and 28-day mortality in critically ill AF patients, as well as an L-shaped correlation between maximum glucose and mortality. However, additional research is necessary to explore the underlying factors contributing to this association.

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Characteristics and feeding intolerance in critically ill adult patients receiving peptide-based enteral nutrition: A retrospective cross-sectional study

Nguyen,

Schott,

Lowen

et al. 2024

Clinical Nutrition ESPEN

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Hospital related hyperglycemia as a predictor of mortality in non-diabetes patients: A systematic review

Cited by 5 publications

References 18 publications

Effect of cortisol and glycosylated-hemoglobin levels on mortality in intensive care unit

Effect of cortisol and glycosylated-hemoglobin levels on mortality in intensive care unit

Nonlinear Relationship Between Blood Glucose and 28-day Mortality in Critically Ill Patients with Atrial Fibrillation

Characteristics and feeding intolerance in critically ill adult patients receiving peptide-based enteral nutrition: A retrospective cross-sectional study

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