Hospitalisations for falls and hip fractures attributable to vitamin D deficiency in older Australians

Wilson, Louise F.; Black, Lucinda J; Waterhouse, Mary; Lucas, Robyn; Gordon, Louisa G.

doi:10.1017/s0007114521000416

Cited by 12 publications

(18 citation statements)

References 20 publications

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“…The study of Lauretani et al conducted on 974 Italian patients with an average age of 85.7 admitted to hospital because of HFs showed that 84.2% of them had a vitamin D3 deficiency [ 70 ]. Similar relationships were presented by Johnson et al [ 71 ] and Neale et al [ 72 ], who conducted studies among patients who live in sunny areas.…”

Section: Hip Fracturessupporting

confidence: 83%

“…Consequently, decreased serum vitamin D levels seem to be associated with an increased risk of falls and hip fractures. The above analyzed studies also implied that the problem of deficiency applies to very sunny countries [ 71 , 72 ], which suggests the implementation of preventive supplementation with vitamin D3 in the general population, regardless of the place of residence. Studies have also shown the validity of vitamin D3 supplementation after HF as a potential factor improving recuperation [ 66 , 76 , 77 ].…”

Section: Hip Fracturesmentioning

confidence: 99%

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Vitamin D Supplementation and Its Impact on Different Types of Bone Fractures

et al. 2022

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Vitamin D helps to balance the levels of calcium and phosphorus to maintain proper bone structure. It is also involved in essential biological roles and displays a wide spectrum of potential benefits in the human body. Since there are many types of fractures that occur at specific ages and due to different circumstances, the influence of vitamin D on the frequency of a particular fracture may differ. Thus, the authors investigated the possible preventive effect of vitamin D on the risks of vertebral fractures, hip fractures, stress fractures and pediatric fractures. Additional aspects of vitamin D, especially on recuperation after injures and its impact on the severity of particular fractures, were also discussed. It was suggested that vitamin D supplementation may contribute to a reduction in hip fracture risk due to reduced bone turnover, decreased frequency of falls and improved muscle function. Furthermore, vitamin D appears to lower the risk of stress fractures in athletes and military recruits. Due to a nonunified protocol design, presented investigations show inconsistencies between vitamin D supplementation and a decreased risk of vertebral fractures. However, a vitamin D preventive effect on pediatric fractures seems to be implausible.

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Section: Hip Fracturessupporting

confidence: 83%

Section: Hip Fracturesmentioning

confidence: 99%

Vitamin D Supplementation and Its Impact on Different Types of Bone Fractures

et al. 2022

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“…However, as per Rizzoli et al, 11 recommended general measures to counter fragility fractures include insuring the presence of vitamin D sufficiency. This idea appears reasonable given that as per Neale et al, 12 even in a sunny country like Australia sufficient numbers of falls and hip fractures are attributable to a vitamin D deficiency in the affected older adults. Current research further reveals that vitamin D combined with calcium reduces the risk of hip fracture although on its own may not exhibit tangible effects but this could reflect the nature of available studies.…”

Section: Specific Observationsmentioning

confidence: 89%

“…Figure 1 Points at which vitamin D or a lack thereof may influence the hip fracture risk cycle [Key reference sources: 3,6,11,12,16,17 ].…”

Section: Discussionmentioning

confidence: 99%

Older adults and vitamin D hip fracture connections-what is the 2022 research base indicating?

Marks¹

2022

MOJGG

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“…Vitamin D deficiency as defined at this concentration is associated with increased risk of hip fractures in people aged 60 years and over [ 257 ]. It has been estimated that, assuming this association is causal, approximately 8% of hip fractures occurring in adults aged ≥ 65 years in Australia are attributable to vitamin D deficiency (25(OH)D < 50 nmol L −1 ) [ 258 ]. Falls in older adults have also been linked to 25(OH)D concentration < 50 nmol L −1 [ 259 ].…”

Section: Benefits Of Exposure To Uv Radiationmentioning

confidence: 99%

The effects of exposure to solar radiation on human health

Neale

Lucas

Byrne

et al. 2023

Photochem Photobiol Sci

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This assessment by the Environmental Effects Assessment Panel (EEAP) of the Montreal Protocol under the United Nations Environment Programme (UNEP) evaluates the effects of ultraviolet (UV) radiation on human health within the context of the Montreal Protocol and its Amendments. We assess work published since our last comprehensive assessment in 2018. Over the last four years gains have been made in knowledge of the links between sun exposure and health outcomes, mechanisms, and estimates of disease burden, including economic impacts. Of particular note, there is new information about the way in which exposure to UV radiation modulates the immune system, causing both harms and benefits for health. The burden of skin cancer remains high, with many lives lost to melanoma and many more people treated for keratinocyte cancer, but it has been estimated that the Montreal Protocol will prevent 11 million cases of melanoma and 432 million cases of keratinocyte cancer that would otherwise have occurred in the United States in people born between 1890 and 2100. While the incidence of skin cancer continues to rise, rates have stabilised in younger populations in some countries. Mortality has also plateaued, partly due to the use of systemic therapies for advanced disease. However, these therapies are very expensive, contributing to the extremely high economic burden of skin cancer, and emphasising the importance and comparative cost-effectiveness of prevention. Photodermatoses, inflammatory skin conditions induced by exposure to UV radiation, can have a marked detrimental impact on the quality of life of sufferers. More information is emerging about their potential link with commonly used drugs, particularly anti-hypertensives. The eyes are also harmed by over-exposure to UV radiation. The incidence of cataract and pterygium is continuing to rise, and there is now evidence of a link between intraocular melanoma and sun exposure. It has been estimated that the Montreal Protocol will prevent 63 million cases of cataract that would otherwise have occurred in the United States in people born between 1890 and 2100. Despite the clearly established harms, exposure to UV radiation also has benefits for human health. While the best recognised benefit is production of vitamin D, beneficial effects mediated by factors other than vitamin D are emerging. For both sun exposure and vitamin D, there is increasingly convincing evidence of a positive role in diseases related to immune function, including both autoimmune diseases and infection. With its influence on the intensity of UV radiation and global warming, the Montreal Protocol has, and will have, both direct and indirect effects on human health, potentially changing the balance of the risks and benefits of spending time outdoors. Graphical abstract

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Hospitalisations for falls and hip fractures attributable to vitamin D deficiency in older Australians

Cited by 12 publications

References 20 publications

Vitamin D Supplementation and Its Impact on Different Types of Bone Fractures

Vitamin D Supplementation and Its Impact on Different Types of Bone Fractures

Older adults and vitamin D hip fracture connections-what is the 2022 research base indicating?

The effects of exposure to solar radiation on human health

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