Hospitalization costs of coronaviruses diseases in upper-middle-income countries: A systematic review

Rocha-Filho, César Ramos; Martins, Johnny Wallef Leite; Lucchetta, Rosa Camila; Ramalho, Gabriel Sodré; Trevisani, Giulia Fernandes Moça; Rocha, Aline Pereira da; Pinto, Ana Carolina Pereira Nunes; Reis, Felipe Sebastião de Assis; Ferla, Laura Jantsch; Mastroianni, Patrícia de Carvalho; Corrêa, Luci; Saconato, Humberto; Trevisani, Virgínia Fernandes Moça

doi:10.1371/journal.pone.0265003

Cited by 13 publications

(17 citation statements)

References 27 publications

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“…Finally, not to be underestimated are the indirect costs of the disease (i.e., within the profile of COPD/asthma patients) due to the loss of productivity and premature retirement of patients. The importance of these aspects is highlighted by the vast amount of literature dealing with the magnitude of resources needed to treat patients with these severe disorders, and with the public health measures taken by the world governments to face their impact on human psychology, the educational system, and the global economy [ 74 , 75 , 76 , 77 , 78 ]. How can proteomics alleviate these issues?…”

Section: Exploring the Role Of Biomarkersmentioning

confidence: 99%

Proteomic Analysis of Human Sputum for the Diagnosis of Lung Disorders: Where Are We Today?

Iadarola

Viglio

2022

IJMS

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The identification of markers of inflammatory activity at the early stages of pulmonary diseases which share common characteristics that prevent their clear differentiation is of great significance to avoid misdiagnosis, and to understand the intrinsic molecular mechanism of the disorder. The combination of electrophoretic/chromatographic methods with mass spectrometry is currently a promising approach for the identification of candidate biomarkers of a disease. Since the fluid phase of sputum is a rich source of proteins which could provide an early diagnosis of specific lung disorders, it is frequently used in these studies. This report focuses on the state-of-the-art of the application, over the last ten years (2011–2021), of sputum proteomics in the investigation of severe lung disorders such as COPD; asthma; cystic fibrosis; lung cancer and those caused by COVID-19 infection. Analysis of the complete set of proteins found in sputum of patients affected by these disorders has allowed the identification of proteins whose levels change in response to the organism’s condition. Understanding proteome dynamism may help in associating these proteins with alterations in the physiology or progression of diseases investigated.

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Section: Exploring the Role Of Biomarkersmentioning

confidence: 99%

Proteomic Analysis of Human Sputum for the Diagnosis of Lung Disorders: Where Are We Today?

Iadarola

Viglio

2022

IJMS

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“…Hospitalization is one of the most expensive aspects of healthcare service, accounting for one‐third of the total healthcare expenditure in the United States. 1 , 2 , 3 Many health and insurance organizations have attempted to minimize the hospitalization rate by implementing preventive policies, 4 with various clinical and epidemiological factors affecting this index. 5 , 6 , 7 In recent years, several studies have demonstrated the substantial impact of social determinants of health (SDOH) on hospitalization rates.…”

Section: Introductionmentioning

confidence: 99%

The association of patient‐reported social determinants of health and hospitalization rate: A scoping review

Ardekani

Fereidooni

Heydari

et al. 2023

Health Science Reports

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Introduction The interplay between social determinants of health (SDOH) and hospitalization is significant as targeted interventions can improve the social status of the individuals. This interrelation has been historically overlooked in health care. In the present study, we reviewed studies in which the association between patient‐reported social risks and hospitalization rate was assessed. Method We performed a scoping literature review of articles published until September 1, 2022 without time limit. We searched PubMed, Embase, Web of Science, Scopus, and Google Scholar to find relevant studies using terms representing “social determinants of health” and “hospitalization.” Forward and backward reference checking was done for the included studies. All studies that used patient‐reported data as a proxy of social risks to determine the association between social risks and hospitalization rates were included. The screening and data extraction processes were done independently by two authors. In case of disagreement, senior authors were consulted. Results Our search process retrieved a total of 14,852 records. After the duplicate removal and screening process, eight studies met the eligibility criteria, all of which were published from 2020 to 2022. The sample size of the studies ranged from 226 to 56,155 participants. All eight studies investigated the impact of food security on hospitalization, and six investigated economic status. In three studies, latent class analysis was applied to divide participants based on their social risks. Seven studies found a statistically significant association between social risks and hospitalization rates. Conclusion Individuals with social risk factors are more susceptible to hospitalization. There is a need for a paradigm shift to meet these needs and reduce the number of preventable hospitalizations.

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“…Despite more than 2 years having passed since the start of the health crisis, the economic and social levels reached in December 2019 have still not been achieved [ 21 , 22 , 23 ]. Although research efforts are being made extensively in this field, only a limited number of studies describing the economic impact of this disease are available [ 4 , 24 , 25 , 26 , 27 , 28 ]. There is considerable heterogeneity across costing methodologies (simulation, absolute costs, etc.).…”

Section: Introductionmentioning

confidence: 99%

“…There is considerable heterogeneity across costing methodologies (simulation, absolute costs, etc.). We observed a great variation in costs per patient, making comparison challenging even among countries with similar economic status [ 26 , 27 , 28 ]. However, no studies have performed a comparative analysis of ‘intra-hospital’ costs, especially for the costs incurred in important areas such as the emergency department, hospitalisation, and intensive care unit of the same hospital, between 2019 (pre-pandemic) and 2020 (first year of the pandemic).…”

Section: Introductionmentioning

confidence: 99%

Analysis of Healthcare Costs Incurred in Regional Hospitals in Andalusia (Spain) during the COVID-19 Pandemic

López-Villegas

Bautista-Mesa

Acosta-Robles

et al. 2022

IJERPH

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(1) Background: The global health crisis caused by the coronavirus disease (COVID-19) pandemic has led to extreme overloading of different public healthcare systems worldwide. The Spanish Public Healthcare System is one of them. This study aimed to conduct a comparative cost analysis to assess the impact of the COVID-19 pandemic on small- and medium-sized regional hospitals in Andalusia (Spain). (2) Methods: This comparative, multicentre, observational, and retrospective study was designed to perform a comparative cost analysis between the Alto Guadalquivir Health Agency (AGHA) and Poniente University Hospital (PUH), both of which belong to the Spanish Public Health System (PHS). The data included in this study corresponds to the total costs by area and year incurred by the 61,335 patients from both healthcare institutions (AGHA = 36,110; PUH = 25,225) in the areas of hospital emergency service (HES), hospitalisation, and intensive care unit (ICU), during the 24 months of the study period (from 1 January 2019 to 31 December 2020). (3) Results: The analysis results showed a significant increase in costs incurred in 2020 for HES relative to those incurred in 2019 for both AGHA (+14%; p < 0.003) and PUH (+36%; p = 0.002). Additionally, costs incurred for ICU increased significantly in 2020 relative to those incurred in 2019 for both AGHA (+30%; p = 0.003) and PUH (+46%; p = 0.002). Hospitalisation costs for AGHA also increased significantly (+9%; p < 0.012) in 2020 versus those obtained in 2019; however, no significant differences were found for PUH (+6%; p = 1) in the same period analysed. However, the number of patients treated in the areas of HES, hospitalisation, and ICU was significantly reduced throughout 2020 compared to 2019. (4) Conclusions: Our findings show that the costs incurred during 2020 in the regional hospitals of Andalusia (Spain) increased significantly in most of the parameters analysed relative to those incurred in the year before the pandemic (i.e., 2019).

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Hospitalization costs of coronaviruses diseases in upper-middle-income countries: A systematic review

Cited by 13 publications

References 27 publications

Proteomic Analysis of Human Sputum for the Diagnosis of Lung Disorders: Where Are We Today?

Proteomic Analysis of Human Sputum for the Diagnosis of Lung Disorders: Where Are We Today?

The association of patient‐reported social determinants of health and hospitalization rate: A scoping review

Analysis of Healthcare Costs Incurred in Regional Hospitals in Andalusia (Spain) during the COVID-19 Pandemic

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