Hospitalizations and deaths of children and adolescents with Severe Acute Respiratory Infection due to COVID-19 during the epidemiological year of 2020

Abstract

This study aimed to analyze the profile of hospitalizations and factors associated with the deaths of children and adolescents with severe acute respiratory infection (SARI) caused by SARS-CoV-2 nationwide. The study comprised 6,843 children and adolescents hospitalized in 2020 who tested positive for COVID-19, based on data from the Influenza Epidemiological Surveillance Information System. Sociodemographic and clinical profiles, hospitalization frequency, lethality and recovery rates were analyzed. The outcome was recovery or death. The 6,843 children and adolescents comprised 1.9% of SARI hospitalized cases (n = 563,051). Of these, 57.7% developed critical SARI and 90% survived. Comorbidities were present in 40.8%, especially asthma, immunodepression, and neurological and cardiovascular diseases. The main symptoms were fever, cough, dyspnea, respiratory distress, and low oxygen saturation. Among those with critical SARI, 91.4% died. There was a higher frequency of children, especially those under five years of age and of mixed ethnicity. The highest hospitalization frequency occurred in the Southeastern and Northeastern regions, the highest recovery rates in the Southeastern and Southern regions, and the highest lethality rates in the Northern and Northeastern regions. Deaths were associated with ages ranging from 12 to 19 and being under one year of age, living in the Northern and Northeastern regions, progression to critical SARI, and having immunosuppression and cardiovascular disease. In contrast, asthma was associated with lower death rates. The frequency of complications and mortality rates caused by SARS-Cov-2 in the pediatric population are relevant, as well as the severity of the epidemic in the social inequality context and the health services' frailty.

Three years of COVID-19 in children that attend the Mexican Social Security Institute's 1,350 child day-care centers, 2020–2023

“…The lethality rates were 0.2% for children between 10 and 17 and between 6 and 9 years of age, 0.8% for children between 1 and 5 years of age, and 4.2% for children under one year of age (15). On the other hand, a Brazilian study reported that in 2021, that country had a lethality rate due to COVID-19 of 3.7% for children under one year of age, 2.1% for children between 1 and 4 years of age, 4.2% for the group between 5 and 11 years of age, 9% for teen-agers between 12 and 14 years of age, and 9.8% in those between 15 and 18 years of age (16).…”

Factors associated with COVID-19 among hospitalized patients with severe acute respiratory infections in Serbia, 2022–2023: A test negative case-control study

“…Understanding difference in demographics, comorbidity profiles, and clinical course between hospitalized COVID patients compared to non-COVID patients can help inform preventive measures and clinical care. Previous studies have shown that hospitalized COVID patients differ from those with non-COVID diagnoses by age, chest X ray abnormalities, laboratory findings and lung function parameters [8][9][10]. In addition, studies have shown that compared to non-COVID patients, hospitalized COVID patients were more likely to have immunosuppression and cardiovascular disease and asthma, while asthma was associated with better clinical outcomes [11,12].…”

“…In addition, studies have shown that compared to non-COVID patients, hospitalized COVID patients were more likely to have immunosuppression and cardiovascular disease and asthma, while asthma was associated with better clinical outcomes [11,12]. SARS CoV-2 positive SARI patients have also been found to have a three-fold higher risk of mortality [4][5][6][7][8][9][10][11][12].…”