Host Defense Peptides in Wound Healing

Steinstraesser, Lars; Koehler, Till; Jacobsen, Frank; Daigeler, Adrien; Goertz, Ole; Langer, Stefan; Kesting, Marco; Steinau, Hans Ulrich; Eriksson, Elof; Hirsch, Tobias

doi:10.2119/2008-00002.steinstraesser

Cited by 145 publications

(115 citation statements)

References 182 publications

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“…In a prospective, randomized multicenter trial of 131 patients with posttraumatic and surgical cutaneous lesions a tyrothricin-containing powder demonstrated superior efficacy compared to placebo powder with respect to the radius of lesions as well as to a wound index [23]. There is an increasing interest in AMPs such as tyrothricin because these ‘nature’s antibiotics’ are promising agents for virtually new therapeutic approaches in infectious diseases, especially of the skin and for wound healing [24]. The well-known antimicrobial properties of tyrothricin also apply to the tyrothricin 0.1% gel tested in this study.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a Tyrothricin-Containing Wound Gel in an Abrasive Wound Model for Superficial Wounds

Wigger‐Alberti¹,

Stauss-Grabo²,

Grigo³

et al. 2012

Skin Pharmacol Physiol

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Background: Topical preparations are a common treatment for superficial acute wounds, which at the least do not interfere with healing and ideally result in enhanced wound healing irrespective of microbial colonization. Objective: To examine the effects of a topical antimicrobial gel and its vehicle on the wound healing of standardized, superficial abrasions. Methods: Thirty-three healthy volunteers were enrolled in a double-blinded, randomized, intraindividual comparison study. Three standardized, superficial abrasions were induced on their forearms. A tyrothricin 0.1% gel (Tyrosur® gel; Engelhard Arzneimittel GmbH & Co. KG, Niederdorfelden, Germany) and its vehicle were randomly applied to two of the test areas, and one lesion remained untreated. Results: A significant improvement of wound healing was seen with both tyrothricin 0.1% gel and its corresponding vehicle in the clinical assessment. The mean area under the curve (AUC) of wound healing scores was the same for both preparations and the mean reepithelization scores were comparable at all test points over the entire 12 days. A lower mean AUC representing less reepithelization was found for the untreated test fields. Conclusion: The use of tyrothricin 0.1% gel and its corresponding vehicle resulted in statistically significant improved wound healing with an earlier onset of healing in particular. Based on these results obtained using an abrasive wound model, it can be concluded that the addition of tyrothricin 0.1% to the gel vehicle did not interfere with the improved wound healing seen with the vehicle alone.

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Section: Discussionmentioning

confidence: 99%

Efficacy of a Tyrothricin-Containing Wound Gel in an Abrasive Wound Model for Superficial Wounds

Wigger‐Alberti¹,

Stauss-Grabo²,

Grigo³

et al. 2012

Skin Pharmacol Physiol

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“…85 The utilization of peptide based therapies presents an attractive alternative against resistive bacteria. 86 Other alternative treatments have also been explored, including the impact of honey on infection prevention. 87,88 These strategies that look beyond the typical silver and antibiotic based treatments provide potential alternatives to combat antibiotic resistance.…”

Section: Antibacterial Treatment Strategiesmentioning

confidence: 99%

Review: Multimodal bioactive material approaches for wound healing

2018

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Wound healing is a highly complex process of tissue repair that relies on the synergistic effect of a number of different cells, cytokines, enzymes, and growth factors. A deregulation in this process can lead to the formation of a non-healing chronic ulcer. Current treatment options, such as collagen wound dressings, are unable to meet the demand set by the wound environment. Therefore, a multifaceted bioactive dressing is needed to elicit a targeted affect. Wound healing strategies seek to develop a targeted effect through the delivery of a bioactive molecule to the wound by a hydrogel or a polymeric scaffold. This review examines current biomaterial and small molecule-based approaches that seek to develop a bioactive material for targeted wound therapy and accepted wound healing models for testing material efficacy.

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“…At present, data from the literature suggest that AMPs, such as cathelicidin LL-37, HBD-2, HBD-3, psoriasin and RNase 7, are upregulated after skin injury, including burnt skin [5,21,44], whereas cathelicidin expression is low or even absent in the chronic wound stage [6,44]. As LL-37 has a direct effect on wound healing by promoting neovascularization and angiogenesis [5,93], this AMP seems to be the most promising agent for future therapeutic approaches in order to antagonize impaired wound healing.…”

Section: From Bedside To Bench: the Presentmentioning

confidence: 99%

“…However, despite undeniable successes in the preclinical area, only few AMPs have reached the phase of testing in clinical trials so far [45,98,99]. At present, four AMPs were successful in therapeutic clinical trials [5]. Pexiganan, a derivative of magainin, which has been developed for the treatment of infected foot ulcers in patients with diabetes mellitus and which entered phase III trials [45] and has been shown to be equally effective as oral ofloxacin, was finally not approved by the US Food and Drug Administration [98].…”

Section: From Bench To Bedside: the Futurementioning

confidence: 99%

“…More than 1,200 AMPs from different origins – bacteria, plants, insects, reptiles and mammals – have been reported [1,2,3]. The ‘nature’s antibiotics’ form the first line of mammalian host defense against pathogens due to an important function as effector agents of the innate immune system [5]. Recent evidence suggests that AMPs also play an important role as signaling molecules in linking innate and adaptive immune responses [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Peptides and Skin: A Paradigm of Translational Medicine

Körting

Schöllmann²,

Stauss-Grabo³

et al. 2012

Skin Pharmacol Physiol

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Antimicrobial peptides (AMPs) are small, cationic, amphiphilic peptides with broad-spectrum microbicidal activity against both bacteria and fungi. In mammals, AMPs form the first line of host defense against infections and generally play an important role as effector agents of the innate immune system. The AMP era was born more than 6 decades ago when the first cationic cyclic peptide antibiotics, namely polymyxins and tyrothricin, found their way into clinical use. Due to the good clinical experience in the treatment of, for example, infections of mucus membranes as well as the subsequent understanding of mode of action, AMPs are now considered for treatment of inflammatory skin diseases and for improving healing of infected wounds. Based on the preclinical findings, including pathobiochemistry and molecular medicine, targeted therapy strategies are developed and first results indicate that AMPs influence processes of diseased skin. Importantly, in contrast to other antibiotics, AMPs do not seem to propagate the development of antibiotic-resistant micro-organisms. Therefore, AMPs should be tested in clinical trials for their efficacy and tolerability in inflammatory skin diseases and chronic wounds. Apart from possible fields of application, these peptides appear suited as an example of the paradigm of translational medicine for skin diseases which is today seen as a ‘two-way road’ – from bench to bedside and backwards from bedside to bench.

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Host Defense Peptides in Wound Healing

Cited by 145 publications

References 182 publications

Efficacy of a Tyrothricin-Containing Wound Gel in an Abrasive Wound Model for Superficial Wounds

Efficacy of a Tyrothricin-Containing Wound Gel in an Abrasive Wound Model for Superficial Wounds

Review: Multimodal bioactive material approaches for wound healing

Antimicrobial Peptides and Skin: A Paradigm of Translational Medicine

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