Host factors associated with HIV-related oral candidiasis

McCarthy, Gillian M.

doi:10.1016/0030-4220(92)90192-s

Cited by 89 publications

(57 citation statements)

References 39 publications

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“…The pathogenicity of the species of Candida spp are a result of the characteristics of the strains, the immunological status of the host and the local conditions of the sites of infection (17).…”

Section: Discussionmentioning

confidence: 99%

“…In a study of strains from the oral cavity of HIV-positive and HIV-negative volunteers, showed that all of the isolates were proteolytic, even though secretory activity (PZ values) revealed that isolates from HIV-positives were more proteolyic in relation to the control group (23). With regard to the expression of virulence factors, not only are microorganism-dependent factors involved, but also others that strongly host-dependent, such as immunological status and local conditions of the site of infection (17). The pathogenicity of C. albicans is a complex process, involving different stages, colonization, adherence, invasion of tissues and damage to cells of the host, composition of the cell wall and the production of toxins and proteolytic enzymes (6,22).…”

Section: Discussionmentioning

confidence: 99%

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Biotyping and genotypic diversity among oral Candida albicans strains from caries-free and caries-active healthy children

Mardegan¹,

Klein²,

Golvea³

et al. 2006

Braz. J. Microbiol.

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Candida albicans oral strains collected from caries-free and caries-active healthy children ranging from 24 to 36 months old, were studied. The aim of the study was to determine proteinase and phospholipase activities produced by Candida albicans in the two groups and to determine the phenotypic diversity of these enzymes based on genetic polymorphism using the AP-PCR method. Strains identified by morphological and fermentation tests as C. albicans were grown in proteinase and phospholipase agar media at 37ºC for 7 and 4 days, respectively. After the incubation period, the enzyme activity of the proteinase and phospholipase positive strains was measured. All strains were subjected to AP-PCR, using the arbitrary primer AP-3. The enzymatic analysis showed no differences between the two groups. The AP-PCR method was effective in demonstrating intra-individual genetic polymorphism in C. albicans, showing a greater clonal diversity in caries-active versus caries-free children. Dendograms of similarity showed only intra-individual clonal lineage. The results suggest that the enzymatic profile does not depend on the genotypic characteristics of the strains.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Biotyping and genotypic diversity among oral Candida albicans strains from caries-free and caries-active healthy children

Mardegan¹,

Klein²,

Golvea³

et al. 2006

Braz. J. Microbiol.

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“…Oral candidiasis are reported to have an increased prevalence among patients with HIV-infected or AIDS and has been used as diagnostic and prognostic markers for the disease. 6,7,8 The introduction of combination therapies, called HAART as a treatment for HIV-infected patients in the mid-1990s, however has been accompanied by multiple report of reduction in the incidence and prevalence of oral mucosal diseases including oral candidiasis. 6 For instance, Patton et al from United States (1995States ( -1999 have reported significant decrease in the prevalence of oral candidiasis from 20.3% to 16.7%.…”

Section: Acquired Immune Deficiency Syndrome (Aids) Is Caused By Humamentioning

confidence: 99%

“…10,11,12 The presence of oral candidiasis in HIV-infected and AIDS patients was associated with a number factors including low CD4 counts, increased viral load, xerostomia, age and Secretory aspartyl proteinase (Sap), extracellular hydrolytic enzyme was product by Candida. 7,10,13,14 Oral candidiasis occurs more frequently in HIVinfected patients with low CD4 counts. Imam et al found a statistically significant increase in the frequency of HIVrelated oral candidiaisis in patients with CD4 counts of less than 300 cells/mm 3 .…”

Section: Hiv/aids and Oral Candidiasismentioning

confidence: 99%

“…Imam et al found a statistically significant increase in the frequency of HIVrelated oral candidiaisis in patients with CD4 counts of less than 300 cells/mm 3 . 7 This condition made Candida, normally flora normal of oral cavity was easy develop and inadequate immune system will made resistance to Candida decreased and facilitated Candida to invasion of tissue. 10 Viral load has important role in the pathogenesis of oral candidiasis in the HIV-infected and AIDS patients.…”

Section: Hiv/aids and Oral Candidiasismentioning

confidence: 99%

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