Host Factors in Viral Life Cycles

Pérez‐Vilaró, Gemma; Jungfleisch, Jennifer; Saludes, Verónica; Scheller, Nicoletta; Giménez‐Barcons, Mireia; Díez, Juana

doi:10.1051/mmnp/20127509

Cited by 3 publications

(1 citation statement)

References 88 publications

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“…However, the set of intracellular biochemical processes involved in replication of viruses is enormous and deserves special attention in the next generation mathematical models of the within-host infection dynamics. The paper by Perez-Vilaro and coworkers [9] describes some of the most important cell components known as virus host factors which affect the virus replication. This review is focused on HIV and hepatitis C virus, representing two major human pathogens.…”

Section: Mathematics Subject Classification: 92-02 92-06mentioning

confidence: 99%

Preface. Distributed Parameter Systems in Immunology

Banks

Bocharov

Grossman

et al. 2012

Math. Model. Nat. Phenom.

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Mathematical modelling in immunology is about forty years old. This is a great age implying a symphony of experience, creativity and energy. Ever since, there is an increasing attempt to utilize the inherent precision of mathematics to enhance the analytical tools of basic and applied research in immunology. Despite numerous publications on application of mathematical models in immunology, the major communities of the experimental scientists and mathematicians are still disconnected. The genuine integration of modeling and simulation into the immunological mainstream remains a challenge.The immune system represents a complex and tightly regulated set of physical, biochemical and immunological processes occurring in time and space, the outcome of which is dependent on a large number of intra-and inter-cellular parameters. Coordinating a functional immune response requires tightly regulated communication between the cells of the immune system, which occurs in the form of cell-to-cell contact and the release of soluble factors that bind cognate receptors expressed by the cells. The functioning of the immune system involves feedback regulated spatially distributed proliferation,

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Section: Mathematics Subject Classification: 92-02 92-06mentioning

confidence: 99%

Preface. Distributed Parameter Systems in Immunology

Banks

Bocharov

Grossman

et al. 2012

Math. Model. Nat. Phenom.

View full text Add to dashboard Cite

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The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway

et al. 2014

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BackgroundThe nuclear export of unspliced and partially spliced HIV-1 mRNA is mediated by the recognition of a leucine-rich nuclear export signal (NES) in the HIV Rev protein by the host protein CRM1/Exportin1. This makes the CRM1-Rev complex an attractive target for the development of new antiviral drugs. Here we tested the anti-HIV efficacy of ratjadone A, a CRM1 inhibitor derived from myxobacteria.ResultsRatjadone A inhibits HIV infection in vitro in a dose-dependent manner with EC50 values at the nanomolar range. The inhibitory effect of ratjadone A occurs around 12 hours post-infection and is specific for the Rev/CRM1-mediated nuclear export pathway. By using a drug affinity responsive target stability (DARTS) assay we could demonstrate that ratjadone A interferes with the formation of the CRM1-Rev-NES complex by binding to CRM1 but not to Rev.ConclusionRatjadone A exhibits strong anti-HIV activity but low selectivity due to toxic effects. Although this limits its potential use as a therapeutic drug, further studies with derivatives of ratjadones might help to overcome these difficulties in the future.

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Virus-host protein-protein interactions as molecular drug targets for arboviral infections

et al. 2022

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Arboviruses have the potential to spread quickly and cause a global health emergency. These are RNA viruses that use RNA-dependent RNA polymerase (RdRp) for their replication. RdRp lacks proofreading activity, leading to high error rates, low replicative fidelity, and more genetic variability. In addition, shorter generation time and faster evolutionary rate of these viruses lead to re-emergence and recurrence of arboviral infections due to the emergence of new variants and the development of antiviral resistance. During the replication inside the host cell through protein-protein interactions (PPIs), these viruses interact with several host factors and utilize the host cellular machinery for their benefit. Besides this, viruses employ several transmission strategies to combat host innate and adaptive immune responses by manipulating the signaling and metabolic pathways of the hosts. Hence, antiviral therapies targeting host-virus PPIs can provide an alternative broad-spectrum strategy against RNA viruses. The approach of targeting virus-specific proteins for developing antivirals is expected to solve the problem of antiviral drug resistance and combat emerging new variants of these viruses. This review focuses on host-virus PPIs of arboviral infections that directly affect the host immune signaling and metabolic pathways. Better understanding of these mechanisms will develop new therapeutic tools to treat viral infections.

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Host Factors in Viral Life Cycles

Cited by 3 publications

References 88 publications

Preface. Distributed Parameter Systems in Immunology

Preface. Distributed Parameter Systems in Immunology

The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway

Virus-host protein-protein interactions as molecular drug targets for arboviral infections

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