Host factors mediating HIV-1 replication

Friedrich, Brian; Dziuba, Natallia; Li, Guangyu; Endsley, Mark; Murray, James L.; Ferguson, Monique

doi:10.1016/j.virusres.2011.08.001

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Flexible Cofactor Targeting Within Crucial Cellular Pathways1

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Cited by 71 publications

(46 citation statements)

References 253 publications

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“…However, developed anti-HIV-1 drugs seldom target these host proteins. The first Food and Drug Administration-approved antiretroviral drug to target a cellular factor was Maraviroc, a negative allosteric modulator of the CCR5 receptor, which serves to interfere with the entry of HIV-1 (68).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of HIV-1 Transcription and Replication by a Newly Identified Cyclin T1 Splice Variant

Gao

Zhou

et al. 2013

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 99%

Inhibition of HIV-1 Transcription and Replication by a Newly Identified Cyclin T1 Splice Variant

Gao

Zhou

et al. 2013

Journal of Biological Chemistry

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“…These human proteins, referred to here as HIV host factors, are involved in processes such as transcription, translation, and transport of the virus (Friedrich et al, 2011; Goff, 2007). Experimentally, the depletion or disabling of HIV host factors decreases viral replication.…”

Section: Introductionmentioning

confidence: 99%

Positive selection of primate genes that promote HIV-1 replication

et al. 2014

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Evolutionary analyses have revealed that most host-encoded restriction factors against HIV-1 have experienced virus-driven selection during primate evolution. However, HIV also depends on the function of many human proteins, called host factors, for its replication. It is not clear whether virus-driven selection shapes the evolution of host factor genes to the extent that it is known to shape restriction factor genes. We show that 5 out of 40 HIV host factor genes (13%) analyzed do bear strong signatures of positive selection. Some of these genes (CD4, NUP153, RANBP2/NUP358) have been characterized with respect to the HIV lifecycle, while others (ANKRD30A/NY-BR-1 and MAP4) remain relatively uncharacterized. One of these, ANKRD30A, shows the most rapid evolution within this set of genes and is induced by interferon stimulation. We discuss how evolutionary analysis can aid the study of host factors for viral replication, just as it has the study of host immunity systems.

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“…2 HIV-1 uses CD4 as its primary receptor and the major coreceptors CCR5 and CXCR4 to gain entrance into host cells. [3][4][5] Following entry, the viral core is partially disassembled, allowing viral RNA and proteins access to the cytoplasm.…”

Section: Introductionmentioning

confidence: 99%