2011
DOI: 10.1021/jp203940s
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Host–Guest Assembly of pH-Responsive Degradable Microcapsules with Controlled Drug Release Behavior

Abstract: Biodegradable microcapsules with pH-responsibility were fabricated with host–guest interaction between β-cyclodextrin (β-CD) and adamantane (AD). Two biocompatible polymers, dextran-graft-β-CD (Dex-g-β-CD) and poly(aspartic-graft-adamantane) (PASP-g-AD), were assembled on CaCO3 particles. Rhodamine B (Rh B) was captured in the core as a model drug. With CaCO3 particles removed by EDTA, hollow microcapsules loaded with Rh B were obtained. As β-CD was grafted to polyaldehyde dextran (PAD) through pH-sensitive C… Show more

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Cited by 64 publications
(45 citation statements)
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“…β-Cyclodextrin is stable in neutral and alkaline medium but will dissociate in strong acids. 29 Nevertheless, the pH effect on the PL intensity of β-CD-Mn-ZnS QDs was examined in a broad pH range 4-12. The results (Fig.…”
Section: Chiral-sensing For Tryptophan Enantiomersmentioning
confidence: 99%
“…β-Cyclodextrin is stable in neutral and alkaline medium but will dissociate in strong acids. 29 Nevertheless, the pH effect on the PL intensity of β-CD-Mn-ZnS QDs was examined in a broad pH range 4-12. The results (Fig.…”
Section: Chiral-sensing For Tryptophan Enantiomersmentioning
confidence: 99%
“…For example, Zhang and coworkers employed the layer-by-layer (LbL) microcapsule formation containing -CD [9] and -CD [59] with a defined number of layers. They reported hollow microcapsules by utilizing CD-guest complexation (physical processes involving hydrophobic and van der Waals interactions), electrostatic interactions for assembling layers (physical process), and the removal of the CaCO 3 core by EDTA (chemical process, dissolution).…”
Section: Combined Physical and Chemical Methodsmentioning
confidence: 99%
“…46 Using the CaCO 3 particles as templates and the layer-bylayer (LbL) assembly driven by the host-guest interaction, hybrid particles with a LbL shell were able to be achieved. 47,48 After removing the carbonate core, LbL hollow microcapsules were obtained. Compared with the traditional electrostatic LbL assembly, a few high molecular weight polycations, which showed obvious toxicity to organisms, were introduced into these kinds of microcapsules.…”
Section: Hybrid Nanoassembliesmentioning
confidence: 99%