Host-guest inclusion systems of podophyllotoxin with β-cyclodextrin derivatives for low cytotoxicity

Li, Fanjie; Yang, Waixiang; Kong, Lingguang; Hong, Haoling; Liao, Xiali; Zhao, Yue; Gao, Chuanzhu; Yang, Bo

doi:10.1016/j.jddst.2019.101280

Cited by 7 publications

(9 citation statements)

References 33 publications

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“…3.2. 1 H and 13 C NMR Analysis of SACD. To further investigate the molecular structures and uniformity of SACD, 1 H and 13 C NMR spectra were acquired (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

“…1 H and 13 C NMR Analysis of SACD. To further investigate the molecular structures and uniformity of SACD, 1 H and 13 C NMR spectra were acquired (Figure 2). As illustrated in Figure 2A, the proton signals of SA appeared at δ = 2.67 ppm (−CH 2 −), while β-CD exhibited signals of protons at δ = 4.95 (H-1), δ = 3.84 (H-3), δ = 3.70−3.81 ppm (H-6 and H-5), δ = 3.50−3.57 ppm (H-4), and δ = 3.43−3.49 ppm (H-2).…”

Section: Resultsmentioning

confidence: 99%

“…The molecular structure of SACD was determined by a Nicolet Nexus 470 Fourier transform infrared (FTIR) spectrometer (Thermo Electron Corporation, Waltham, MA, USA) from 400 to 4000 cm −1 . 1 H NMR and 13 C NMR spectra were collected on a nuclear magnetic resonance spectrometer (AVANCE III 400 MHz, Bruker, Billerica, MA, USA) using D 2 O as a solvent. High-performance liquid chromatography (HPLC, Waters 1525EF) was used to distinguish unreacted β-CD in SACD samples.…”

Section: Methodsmentioning

confidence: 99%

“…For instance, hydroxypropyl-β-CD (HP-β-CD) has been reported to have better water dispersibility than β-CD but a similar encapsulation capacity . In general, selected chemical modification of β-CD can be used to enhance its functional performance . Celebioglu et al showed that methyl-β-CD (M-β-CD) formed stronger inclusion complexes with eugenol than HP-β-CD.…”

Section: Introductionmentioning

confidence: 99%

“…12 In general, selected chemical modification of β-CD can be used to enhance its functional performance. 13 Celebioglu et al 14 showed that methyl-β-CD (M-β-CD) formed stronger inclusion complexes with eugenol than HP-β-CD. Azzi et al 15 reported that sulfobutylether-β-CD (SBE-β-CD) had a stronger binding affinity for a model phytochemical (quercetin) than either HP-β-CD or β-CD.…”

Section: Introductionmentioning

confidence: 99%

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Simple Strategy Preparing Cyclodextrin Carboxylate as a Highly Effective Carrier for Bioactive Compounds

Qiu

McClements

et al. 2021

J. Agric. Food Chem.

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Many phytochemicals suffer from poor water dispersity and storage stability, which restrict their application within aqueous-based commercial products. β-Cyclodextrin (β-CD) is a water-dispersible molecule with a hydrophobic core that can encapsulate and protect non-polar substances. The functional attributes of β-CD can be further enhanced by chemical modification. In this study, a simple and effective dry-heating process was applied to fabricate succinic acid (SA)-modified β-CD (SACD) through esterification. SACD showed better encapsulation property than non-modified β-CD to guest molecules such as methyl orange (up to 1.41-folds of β-CD) and curcumin (with an encapsulation efficiency of up to 10 mg/g). Meanwhile, higher water solubility (up to 469.30 g per 100 g of H 2 O) was achieved for SACD, indicating that a high dose of SACD could be applied in an aqueous food matrix. Such a simple strategy exhibiting low cytotoxicity shows great potential incorporating bioactive compounds into functional foods.

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“…3.2. 1 H and 13 C NMR Analysis of SACD. To further investigate the molecular structures and uniformity of SACD, 1 H and 13 C NMR spectra were acquired (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%