Host–Guest Recognition of Pesticides by Calixarenes

Sanabria, Edilma; Maldonado, Mauricio

doi:10.1080/10408347.2018.1534200

Cited by 30 publications

(7 citation statements)

References 68 publications

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“…All of this has been possible due to the fact that these compounds are able to form a complex with molecules of biological interest such as antibiotics [1], proteins and nucleic acids [4], food nutraceuticals [5], and cholesterol [7], among many other compounds. In particular, the calixarenes are able to form a guest–host inclusion complex with molecules such as anthelmintics [8], testosterone [9], steroid hormones [10], antibacterial drugs [11], sugars [12], alditols [13], lectin [14], protein [15], and pesticides [16,17]. In addition, they have exhibited antiviral [18], antithrombotic [19], antibactericidal [20], antituberculosis [21], and anticancer activity [22].…”

Section: Introductionmentioning

confidence: 99%

Calixarenes: Generalities and Their Role in Improving the Solubility, Biocompatibility, Stability, Bioavailability, Detection, and Transport of Biomolecules

2019

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The properties and characteristics of calix[n]arenes are described, as well as their capacity to form amphiphilic assemblies by means of the design of synthetic macrocycles with a hydrophilic head and a hydrophobic tail. Their interaction with various substances of interest in pharmacy, engineering, and medicine is also described. In particular, the role of the calix[n]arenes in the detection of dopamine, the design of vesicles and liposomes employed in the manufacture of systems of controlled release drugs used in the treatment of cancer, and their role in improving the solubility of testosterone and anthelmintic drugs and the biocompatibility of biomaterials useful for the manufacture of synthetic organs is emphasized. The versatility of these macrocycles, able to vary in size, shape, functional groups, and hydrophobicity and to recognize various biomolecules and molecules with biological activity without causing cytotoxicity is highlighted.

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Section: Introductionmentioning

confidence: 99%

Calixarenes: Generalities and Their Role in Improving the Solubility, Biocompatibility, Stability, Bioavailability, Detection, and Transport of Biomolecules

2019

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“…Nanomaterials are important inventions for many applications, such as nanosensors and drug delivery systems (Azahari et al, 2012;Lim et al, 2020). In particular, the contribution of host-guest nano-molecules, known as calixarenes, encompasses various sectors, including biosensors, healthcare, biomedical, and transport agents in biological systems Edwards et al, 2021;Kumar et al, 2019;Sanabria Español & Maldonado, 2019). Structurally, calixarenes consist of repeating phenol units linked via alkylidene groups with unique upper rims and basket-like lower rims (Shinkai, 1993).…”

Section: Introductionmentioning

confidence: 99%

The Molecular Behaviors of Calixarenes at the Air-Water Interface: Density Functional Theory, Surface Pressure, Potential, and Effective Dipole Moment

Supian

Yi²,

Karim³

et al. 2022

MJS

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This study examined the behaviors of Langmuir-Blodgett ultrathin calixarene films at the air-water interface. The Langmuir trough was used to estimate the surface pressure, surface potential, and effective dipole moment of two calixarenes, namely, calix[4]arene (THC4) and calix[8]arene (THC8). The band gap was determined using the density functional theory (DFT). The DFT simulation gave a band gap of 2.28 eV for THC4, confirming that THC4 was an insulator. The surface pressure isotherms of THC4 and THC8 yielded the expected molecular behavior from the gaseous to the solid phases. THC4 and THC8 showed a perpendicular and a parallel orientation in the air-water subphase, respectively. The ∆Vmax values of TCH4 and THC 8 were 205 mV and 141mV, respectively, and their µ﬩max values were 0.147 D and 0.088 D, respectively.

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“…Many analytical methods for paraquat detection, including HPLC [ 32 ] and UPLC-HRMS [ 33 ], have been developed and demonstrated to be reliable, but the requirements of expensive instruments and sophisticated skills limit their application. Nanomaterial-based sensors such as enzyme inhibition [ 34 ], nanozyme-based sensors [ 35 ], aptasensors [ 36 ], immunosensors [ 37 ], and host–guest recognition [ 38 ] methods for pesticide detection have attracted great attention from researchers. However, the above methods may suffer from shortcomings such as biomacromolecule denaturation, lengthy steps, and time-consuming protocols.…”

Section: Introductionmentioning

confidence: 99%

A Fluorescent Detection for Paraquat Based on β-CDs-Enhanced Fluorescent Gold Nanoclusters

Ren

Mao

et al. 2021

Foods

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In this report, a fluorescent sensing method for paraquat based on gold nanoclusters (AuNCs) is proposed. It was found that paraquat could quench both glutathione-capped AuNCs (GSH-AuNCs) and β-cyclodextrin-modified GSH-AuNCs (GSH/β-CDs-AuNCs). The modification of β-CDs on the surface of GSH-AuNCs obviously enhanced the fluorescence intensity of GSH-AuNCs and improved the sensitivity of paraquat sensing more than 4-fold. This sensibilization was ascribed to the obvious fluorescence intensity enhancement of GSH-AuNCs by β-CDs and the “host–guest” interaction between paraquat and β-CDs. The fluorescence quenching was mainly due to the photoinduced energy transfer (PET) between GSH/β-CDs-AuNCs and paraquat. With the optimized β-CDs modification of the GSH-AuNC surfaces and under buffer conditions, the fluorescent detection for paraquat demonstrated a linear response in the range of 5.0–350 ng/mL with a detection limit of 1.2 ng/mL. The fluorescent method also showed high selectivity toward common pesticides. The interference from metal ions could be easily masked by ethylene diamine tetraacetic acid (EDTA). This method was applied to the measurement of paraquat-spiked water samples and good recoveries (93.6–103.8%) were obtained. The above results indicate that host molecule modification of fluorescent metal NC surfaces has high potential in the development of robust fluorescent sensors.

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Host–Guest Recognition of Pesticides by Calixarenes

Cited by 30 publications

References 68 publications

Calixarenes: Generalities and Their Role in Improving the Solubility, Biocompatibility, Stability, Bioavailability, Detection, and Transport of Biomolecules

Calixarenes: Generalities and Their Role in Improving the Solubility, Biocompatibility, Stability, Bioavailability, Detection, and Transport of Biomolecules

The Molecular Behaviors of Calixarenes at the Air-Water Interface: Density Functional Theory, Surface Pressure, Potential, and Effective Dipole Moment

A Fluorescent Detection for Paraquat Based on β-CDs-Enhanced Fluorescent Gold Nanoclusters

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