Host-Induced Modifications of Viruses

Luria, Salvador E.

doi:10.1101/sqb.1953.018.01.034

Cited by 142 publications

(61 citation statements)

References 15 publications

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“…The terminology used for describing the various aspects of host-controlled modification is mainly that of Luria (1953) (see also summary of terminology by Paigen and Weinfeld 1963).…”

Section: (A) Bacteria and Phage mentioning

confidence: 99%

“…Although the types of variation (excepting the changes observed for initial passage through L2, L7, or L25) described for 0Ll and 0L5 conform to commonly accepted criteria (Luria 1953) for host-controlled phenotypic changes rather than for mutation, some analyses were made of the distribution of unrestricted and restricted 0L5 forms in one-step L25 lysates. The frequency of unrestricted particles (i.e.…”

Section: (D) One-step Growth Of 0l5· L25 In L25 Cellsmentioning

confidence: 99%

“…Host-controlled phenotypic modification or variation is known to occur in phage active on a number of genera of bacteria, including the Escherichia-ShigellarSalmonella group (see review by Luria 1953), Staphylococcus (Ralston and Krueger 1952), Streptococcus (Collins 1956), and Pseudo'fIWnas (Holloway and Rolfe 1964), but has not previously been reported for phage of Rhizobium. Aside from the basic interest attached to the incompletely understood mechanisms of phenotypic variation, this type of variation is of practical interest in various areas of microbial research, including routine maintenance or identification of phage strains.…”

Section: Introductionmentioning

confidence: 99%

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Host-Controlled Modification of Rhizobium Bacteriophage

Schwinghamer¹

1965

Aust. Jnl. Of Bio. Sci.

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SummaryHost-controlled phenotypic variation of host specificity was observed with two rhizobiophage strains, 0Ll and 0L5, following growth on six strains of Rhizobium legumino8arum and R. trifolii. The six hosts could be assigned to four groups, each group representing a different pattern of host specificity. Initial adaptation of 0L5 to hosts L2, L7, and L25 appeared to involve mutation, although replication in cells of these hosts generally involved additional phenotypic restriction. Restricted and unrestricted forms of a phage did not differ significantly in their ability to adsorb to several hosts. One-step analysis of the L25-specific form of 0L5 grown in L25 cells indicated a low average burst size of approximately one unrestricted plaqueforming unit in a small proportion of cells which were able to produce infective centres on L4. One-cycle analysis of L4-specific 0L5 modified by growth in L25 confirmed the phenotypic nature of phage variation in this phage-host system, and indicated that specificity for L4 was not replicated in L25.

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“…The terminology used for describing the various aspects of host-controlled modification is mainly that of Luria (1953) (see also summary of terminology by Paigen and Weinfeld 1963).…”

Section: (A) Bacteria and Phage mentioning

confidence: 99%

Section: (D) One-step Growth Of 0l5· L25 In L25 Cellsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Host-Controlled Modification of Rhizobium Bacteriophage

Schwinghamer¹

1965

Aust. Jnl. Of Bio. Sci.

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“…Such viruses might possibly arise from genetic reversions or simply from the fact that they were synthesized in cystine-supplied cells (cf. Luria, 1953). Seven isolates from typical Akron cri plaques were tested and found to contain cri virus.…”

Section: Mabie Cri Viruses (Pp5's) On Cystine-supplied Cellsmentioning

confidence: 99%

Poliovirus Mutants with Altered Responses to Cystine

Dubes

Chapin

1958

Journal of General Microbiology

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SUMMARY: Three strains of poliovirus (Akron, antigenic type 1; Brooks, type 2 ; Mabie, type 3), which require exogenously supplied cystine (or a cystine-substitute) for optimal cytopathogenic action on monkey kidney tissue cultures, were serially passaged ten times in cystine-deficient monkey kidney tissue cultures in tubes. From various passage levels in this system were isolated three mutants of Akron, four of Brooks and two of Mabie. These nine mutants are designated the cystine-response mutants and are distinguishable from their ancestral viruses used to initiate the passage series by being relatively cystine-non-requiring. Two criteria suffice to distinguish the mutants of any strain from each other: (1) the degree of loss of requirement for cystine, and (2) the degree of inhibition by relatively high concentrations of cystine. The compositions of the virus populations in most of the passage levels were determined, and from these determinations the patterns of emergence of the mutant viruses were delineated.

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“…It is likely that most indicators classified as resistant by spot tests are truly resistant (absence of phage receptors). However, it is possible that in some in stances successful adsorptions did occur but the infections were abortive, due for instance to restriction of the phage by the indicator cells as reported for T2 by Luria [8]. Experiments meant to exclude this possibility have not yet been conducted.…”

mentioning

confidence: 99%