Host–pathogen interactions between the skin and Staphylococcus aureus

Abstract

Staphylococcus aureus is responsible for the vast majority of bacterial skin infections in humans. The propensity for S. aureus to infect skin involves a balance between cutaneous immune defense mechanisms and virulence factors of the pathogen. The tissue architecture of the skin is different than other epithelia especially since it possesses a corneal layer, which is an important barrier that protects against the pathogenic microorganisms in the environment. The skin surface, epidermis and dermis each contribute to host defense against S. aureus. Conversely, S. aureus utilizes various mechanisms to evade these host defenses to promote colonization and infection of the skin. This review will focus on host-pathogen interactions at the skin interface during the pathogenesis of S. aureus colonization and infection.

Synergistic Effect between Fucoidan and Antibiotics against Clinic Methicillin-Resistant <i>Staphylococcus aureus</i>

“…Staphylococcus aureus is known to be a versatile pathogen causing a side variety of community and hospital acquired infections that are associated with high morbidity and mortality rates [1] [2]. Methicillin-resistant Staphylococcus aureus (MRSA) infections are becoming increasingly widespread [3].…”

p-Cymene Based Organometallic Ruthenium(II)-Arene Complexes with Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity

“…Some of them were clinically isolated S. aureus and control strain S. aureus ATCC 25923 strains, pyogenic bacteria known to play a significant role in invasive skin diseases including deep and superficial infections such as impetigo, cellulitis, folliculitis, subcutaneous abscesses, infected ulcers and wounds. 28 C. albicans was also chosen for this study since it is an infection of the yeast fungus, which occurs on the surface of the tongue and inside the mucus of the cheeks. S. aureus and C. albicans are often co-isolated in cases of biofilm associated infections.…”

Bacterial superantigens and superantigen-like toxins

“…S. aureus was isolated by Anton Rosenbach in 1884 and so named for its golden color (aurum: Latin for "gold") [87]. Although this Gram-positive bacterium asymptomatically colonizes the nares, skin, and throats of approximately half the population at any one time, it is considered an opportunistic pathogen with the potential to infect practically any part of the body [88,89]. The most common clinical manifestation of disease is skin and soft tissue infection (SSTI).…”