Host-pathogen interactions: lessons from phagocytic predation on fungi

Radosa, Silvia; Hillmann, Falk

doi:10.1016/j.mib.2021.04.010

Cited by 5 publications

(1 citation statement)

References 41 publications

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“…Such predators can be small animals (such as nematodes) or free-living amoebae [38] . The latter employ feeding mechanisms that are strikingly similar to phagocytosis by mammalian innate immune cells [38] , [39] , [61] , [62] . Environmental fungi evolved strategies to resist ingestion by amoebae or survive intracellular killing, which mediate cross-adaptation to human phagocytes [18] , [36] , [38] , [63] , [64] .…”

Section: Evolution Of Immune Evasionmentioning

confidence: 99%

“Under Pressure” – How fungi evade, exploit, and modulate cells of the innate immune system

Lange¹,

Kasper²,

Gresnigt³

et al. 2023

Seminars in Immunology

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Section: Evolution Of Immune Evasionmentioning

confidence: 99%

“Under Pressure” – How fungi evade, exploit, and modulate cells of the innate immune system

Lange¹,

Kasper²,

Gresnigt³

et al. 2023

Seminars in Immunology

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Editorial overview: Niche-specific and species-specific host-fungal interactions — how do they impact human health?

Drummond¹,

Obar²

2021

Current Opinion in Microbiology

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Immunity to Invasive Fungal Diseases

Casadevall

2022

Annu. Rev. Immunol.

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Invasive fungal diseases are rare in individuals with intact immunity. This, together with the fact that there are only a few species that account for most mycotic diseases, implies a remarkable natural resistance to pathogenic fungi. Mammalian immunity to fungi rests on two pillars, powerful immune mechanisms and elevated temperatures that create a thermal restriction zone for most fungal species. Conditions associated with increased susceptibility generally reflect major disturbances of immune function involving both the cellular and humoral innate and adaptive arms, which implies considerable redundancy in host defense mechanisms against fungi. In general, tissue fungal invasion is controlled through either neutrophil or granulomatous inflammation, depending on the fungal species. Neutrophils are critical against Candida spp. and Aspergillus spp. while macrophages are essential for controlling mycoses due to Cryptococcus spp., Histoplasma spp., and other fungi. The increasing number of immunocompromised patients together with climate change could significantly increase the prevalence of fungal diseases. Expected final online publication date for the Annual Review of Immunology, Volume 40 is April 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Host-pathogen interactions: lessons from phagocytic predation on fungi

Cited by 5 publications

References 41 publications

“Under Pressure” – How fungi evade, exploit, and modulate cells of the innate immune system

“Under Pressure” – How fungi evade, exploit, and modulate cells of the innate immune system

Editorial overview: Niche-specific and species-specific host-fungal interactions — how do they impact human health?

Immunity to Invasive Fungal Diseases

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