Host‐tumor Antagonism. Ix. The Reticulo‐endothelial System and Neoplasia†

Effect of Stimulation of the Host Defense System by Coenzyme Q 10 on Dibenzpyrene-Induced Tumors and Infection with Friend Leukemia Virus in Mice

“…The importance of the host defense system [which includes, in part,.the reticuloendothelial system (RES) ] in resistance to neoplasia has been demonstrated clinically and in experimental animals and has been the subject of studies by a growing number of investigators (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Substances known to stimulate the RES, such as bacterial endotoxin, zymosan, glucan, Bacillus Calmette-Gu6rin, and others, inhibit the growth of some experimental tumors (1,2,4,5,10,(13)(14)(15)(16)(17)(18)(19).…”

“…Substances known to stimulate the RES, such as bacterial endotoxin, zymosan, glucan, Bacillus Calmette-Gu6rin, and others, inhibit the growth of some experimental tumors (1,2,4,5,10,(13)(14)(15)(16)(17)(18)(19). In contrast, substances that depress RES activity stimulate the growth of some tumors or increase the incidence of metastasis in cases in which neoplasm already exists (10,(20)(21)(22)(23)(24).…”