Host‐tumor Antagonism. Xii. Possible Effect of the Cortisone Drugs on the Development of Metastases in Patients With Carcinoma†

Systematic review of the clinical effect of glucocorticoids on nonhematologic malignancy

“…Three clinical trials, with no available results, were identified [ 71 - 73 ]. Nine case reports of glucocorticoid monotherapy, other than breast cancer or prostate cancer or thymoma regressing in response to glucocorticoid monotherapy, were found [ 74 - 83 ]. No article was excluded due to quality.…”

“…Metastatic renal cell carcinoma might have shown a complete response to glucocorticoids in two patients[ 78 , 79 ]. There are case reports where glucocorticoids apparently stimulated the growth of breast cancers [ 80 - 83 ].…”

Synergism between host anti‐tumor immunity and combined modality therapy against murine breast cancer

“…Nevertheless, accumulating evidence suggests that immunity still can be a determining factor in the outcome of cancer therapy. For example, augmented tumor growth has been observed following immunosuppressive drug therapy with cortisone (Agosin et al, 1952;Pelner, 1959;Hartmann and Sherlock, 1961) o r with prolonged intensive (i.e., immunosuppressive) administration of anti-cancer agents (Kondo and Moore, 1961;Southam, 1966, 1967;Fefer, 1969;Watanabe and Tanaka, 1969). In contrast, there is recent experimental evidence Received: September 4, 1973 and in revised form November 28, 1973. 389 that host immunity, if not suppressed by drug therapy, can potentiate the anti-tumor effect of chemotherapy.…”

Host‐tumor Antagonism. Xxx. Some Systemic Manifestations of Cancer*

“…In some of the animal experiments, the metastases were widespread although the local tumor decreased in size. Pelner (48) reported 4 cases of metastatic spread of carcinoma soon after the initiation of therapy with one of the corticosteroid drugs. Other confirmatory reports have appeared in the literature.…”