Hot-band absorption assisted single-photon frequency upconversion luminescent nanophotosensitizer for 808 nm light triggered photodynamic immunotherapy of cancer

Abstract

We propose upconversion luminescent phthalocyanine nanophotosensitizer PdPc NPs with anti-Stokes emission at 748 nm triggered by 808 nm laser. After synergizing with anti-PDL1, the system could achieve prominent photodynamic sensitized immunotherapy.

Mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precision cancer gas therapy

“…Among them, frequency upconversion luminescence (FUCL) has gained prominence in biosensing and imaging due to its superior properties of deep-tissue penetration, low autofluorescence, high photostability, and high signal-to-noise ratio. Furthermore, diverse FUCL-based systems have been extensively developed for detecting metal ions, tumor hypoxia, and cancer therapy 35 , 36 , 37 , 38 , 39 , 40 , 41 . Recently, our group reported the design of 658 nm light-activable upconversion luminescent NO nano-prodrugs that facilitated precise real-time NO monitoring and tumor treatment guided by FUCL imaging 42 .…”

Boosted photo-immunotherapy via near-infrared light excited phototherapy in tumor sites and photo-activation in sentinel lymph nodes

“…[13][14][15] The exposure of dead cells to TAAs can enhance antigen-specic T-cell responses and the released DAMPs, which can induce dendritic cell (DC) maturation, trigger T-cell activation, and consequently trigger anti-tumor immune response. 16,17 Considering that photoimmunotherapy, with high spatiotemporal precision and excellent safety, has emerged as a promising tool for solid tumor ablation and ICD induction, and therefore various phototherapeutic agents, including aggregation-induced emission luminogens, [18][19][20] nanosized metal-organic frameworks, [21][22][23] black phosphorous (BP) nanomaterial, [24][25][26] carbon nanomaterial, [27][28][29] up-conversion nanoparticles, 18,30,31 and subcellular targeted nanoparticles (NPs), 15,32,33 have been designed and synthesized for photo-immunotherapy. However, treating tumors with phototherapy alone is not efficient to induce durable and robust tumor immunogenicity against tumor recurrence and metastasis.…”

Albumin-based near-infrared phototheranostics for frequency upconversion luminescence/photoacoustic dual-modal imaging-guided photothermal therapy

“…50,51 54 Liu et al went further to expand the application of FUCL in gas therapy, PDT and immunotherapy of cancer. 55,56 Moreover, FUCL dyes with tunable chemical structures and near infrared (NIR) absorption can be further applied for PAI-guided PTT. To overcome the high hydrophobicity and short retention of most organic PA and FUCL agents, bovine serum albumin (BSA) was introduced as a nanocarrier to improve the water solubility and biocompatibility of the agents.…”