Additive manufacturing techniques offer significant advantages for creating complex components efficiently, saving both time and materials. This makes them particularly appealing for producing parts from intricate alloys, such as Hastelloy C-22. One such technique, plasma metal deposition, uses plasma on powdered material to build up layers. The novelty of this work is to analyze and determine whether there is a correlation between the particle size and the final behaviour of specimens produced via additive manufacturing. To achieve this, four powders with an identical chemical composition but different granulometries were employed. Additionally, some of the samples underwent thermal treatment (progressive heating at 10 °C/min until 1120 °C, maintained for 20 min, followed by rapid air cooling). Four walls were constructed, and after mechanical, tribological, and microstructural characterization, it was determined that the influence of the thermal treatment remained consistent, regardless of particle size. It was observed that the particle size slightly affected the final properties: the finer the powder, the lower the ultimate tensile strength values. Furthermore, it was evident that the thermal treatment substantially affected the microstructure and wear behavior of all the specimens, regardless of their initial particle size.