Hot Spots and Trends in the Relationship between Cancer and Obesity: A Systematic Review and Knowledge Graph Analysis

Gao, Le; Yang, Tian; Xue, Ziru; Chan, Chak Kwan

doi:10.3390/life13020337

Cited by 5 publications

(3 citation statements)

References 69 publications

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“…Gao et al . 58 constructed a knowledge graph to delineate the association between cancer and obesity. This research archived two decades of data on cancer and obesity, including PCa.…”

Section: Discussionmentioning

confidence: 99%

RARPKB: A knowledge-guide decision support platform for personalized robot-assisted surgery in prostate cancer

Li,

Tang,

et al. 2024

International Journal of Surgery

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Background: Robot-assisted radical prostatectomy (RARP) has emerged as a pivotal surgical intervention for the treatment of prostate cancer. However, the complexity of clinical cases, heterogeneity of prostate cancer, and limitations in physician expertise pose challenges to rational decision-making in RARP. To address these challenges, we aimed to organize the knowledge of previously complex cohorts and establish an online platform named the RARP Knowledge Base (RARPKB) to provide reference evidence for personalized treatment plans. Materials and Methods: PubMed searches over the past two decades were conducted to identify publications describing RARP. We collected, classified, and structured surgical details, patient information, surgical data, and various statistical results from the literature. A knowledge-guided decision-support tool was established using MySQL, DataTable, ECharts, and JavaScript. ChatGPT-4 and two assessment scales were used to validate and compare the platform. Results: The platform comprised 583 studies, 1589 cohorts, 1 911 968 patients, and 11 986 records, resulting in 54 834 data entries. The knowledge-guided decision support tool provide personalized surgical plan recommendations and potential complications on the basis of patients’ baseline and surgical information. Compared with ChatGPT-4, RARPKB outperformed in authenticity (100% versus [vs.] 73%), matching (100% vs. 53%), personalized recommendations (100% vs. 20%), matching of patients (100% vs. 0%), and personalized recommendations for complications (100% vs. 20%). Post-use, the average System Usability Scale score was 88.88±15.03, and the Net Promoter Score of RARPKB was 85. The knowledge base is available at http://rarpkb.bioinf.org.cn. Conclusions: We introduced the pioneering RARPKB, the first knowledge base for robot-assisted surgery, with an emphasis on prostate cancer. RARPKB can assist in personalized and complex surgical planning for prostate cancer to improve its efficacy. RARPKB provides a reference for the future applications of artificial intelligence in clinical practice.

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“…Gao et al . 58 constructed a knowledge graph to delineate the association between cancer and obesity. This research archived two decades of data on cancer and obesity, including PCa.…”

Section: Discussionmentioning

confidence: 99%

RARPKB: A knowledge-guide decision support platform for personalized robot-assisted surgery in prostate cancer

Li,

Tang,

et al. 2024

International Journal of Surgery

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“…Epidemiological evidence links FV consumption with reduced obesity and increased lifespan ( 30–32 ). Additionally, obesity is associated with the development of malignant tumors ( 33 , 34 ). Therefore, our results suggest that, in the context of consuming a HF diet, FV supplementation may extend median lifespan and reduce tumor incidence at least partially through its beneficial effects on body weight gain and composition.…”

Section: Discussionmentioning

confidence: 99%

Life-long consumption of high level of fruits and vegetables reduces tumor incidence and extends median lifespan in mice

Guo,

Ortega,

et al. 2023

Front. Nutr.

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ObjectiveEpidemiological studies suggest that consumption of fruits and vegetables (FV) is negatively associated with the incidence of certain cancers and mortality. However, a causal relationship has not been demonstrated. Thus, we investigated the effect of life-long consumption of high level of FV on median lifespan, key biological functions, and pathologies in mice fed low-fat (LF) or high-fat (HF) diets and the underlying mechanisms.MethodsUsing a 2 × 2 factorial design, 5 weeks-old male C57BL/6J mice were randomly assigned to one of four groups (n = 60/group): LF (LF-C, 10% kcal fat), HF (HF-C, 45% kcal fat) or each supplemented with 15% (w/w) of a unique FV mixture (LF + FV and HF + FV, respectively). Mice were euthanized when one group reached 50% mortality. Body weight and composition, tumor incidence, and death were monitored. Blood levels of lipids and pro-inflammatory cytokines were assessed.ResultsAfter 21 months of feeding, HF-C group reached 50% mortality, at which time mice in all groups were terminated. HF-C had higher mortality (50.0%) compared to the LF-C group (18.3%, p = 0.0008). Notably, HF-FV had lower mortality (23.3%) compared to HF-C group (p = 0.008); there was no significant difference in mortality between HF-FV and LF-C groups. Tumors were found in all groups, and were predominantly present in the liver, followed by those of lung, intestine, and seminal vesicle. Tumor incidence in the HF-C group (73.3%) was higher than that in LF-C group (30.0%, p < 0.0001). HF + FV group had 23.3% lower tumor incidence compared to the HF-C group (p = 0.014). No significant difference in tumor incidence between the LF-C and LF + FV groups was observed. Long-term FV supplementation reduced systemic inflammation and blood lipids.ConclusionWe provide the first causal evidence that life-long intake of a diet, containing a high level and large variety of FV, decreases tumor incidence and extends median lifespan in mice fed a western-style high-fat diet. These effects of FV are at least in part due to reduced blood levels of pro-inflammatory cytokines and improved dyslipidemia.

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“…Knowledge graph visualization technology provides knowledge basis and technical support for big data analysis and research in various fields, and makes up for the shortcomings of traditional literature review analysis methods (Jeong et al, 2022;Philippe, 2020;. In recent 10 years, knowledge mapping technology has made breakthrough progress in the research of medicine, environment, education, economy, management, geography and other professional fields (Chen et al, 2018;Gao et al, 2023b;Han et al, 2022;Mishra et al, 2022;Shinde et al, 2021;Zhang et al, 2020). Knowledge graph has gradually become an important tool to grasp the development trends of disciplines, main research directions and technology-assisted decision-making.…”

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confidence: 99%

Visual analysis of contaminated site studies in recent 30 years based on bibliometrics and knowledge graph

Gao,

Xue,

Gnanachandrasamy

2024

Environ Dev Sustain

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The problem of contaminated sites is a hot and difficult issue in global environmental sustainable development. Because the contaminated site carries a large number of harmful substances (heavy metal ions, organic polycyclic aromatic hydrocarbons, toxic gases, etc.), it brings great security risks to the environmental ecological security and people's health. Effective identification of the characteristics of contaminated sites and understanding of the research status and development trend of contaminated sites are of great significance to environmental sustainable development and environmental governance and restoration. Based on Web of Science database, this study systematically, quantitatively and visually analyzes the research status of contaminated sites by bibliometrics and knowledge graph technology. The results show that bibliometrics and knowledge graph are effective in information retrieval and visualization. It can display the information of different scales and different times in the study of contaminated sites, and find the distribution characteristics of popular keywords. The cluster cases of this study show that the problems of contaminated site research mainly focus on suspended particulate matter pollution, water pollution, heavy metal pollution, organic pollution, pollution reduction and bioremediation technology research. In the future, the hot issues of contaminated site remediation and environmental sustainable development will focus on strengthening the research of microbial remediation technology, nanomaterial technology, composite material adsorption technology and so on.

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Hot Spots and Trends in the Relationship between Cancer and Obesity: A Systematic Review and Knowledge Graph Analysis

Cited by 5 publications

References 69 publications

RARPKB: A knowledge-guide decision support platform for personalized robot-assisted surgery in prostate cancer

RARPKB: A knowledge-guide decision support platform for personalized robot-assisted surgery in prostate cancer

Life-long consumption of high level of fruits and vegetables reduces tumor incidence and extends median lifespan in mice

Visual analysis of contaminated site studies in recent 30 years based on bibliometrics and knowledge graph

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