HOTAIR is a promising novel biomarker in patients with thyroid cancer

Zhang, Yifei; Yu, Sui; Jiang, Lixin; Wang, Xixun; Song, Xiaojing

doi:10.3892/etm.2017.4231

Cited by 35 publications

(29 citation statements)

References 23 publications

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“…HOTAIR was significantly up-regulated in TC compared with adjacent tissues. The results were similar to those detected in TC patients’ plasma, whereas there was almost no HOTAIR expression in the plasma of the healthy volunteers [ 121 ]. HOTAIR susceptibility SNP rs920778 genetic variants (such as TT, TC and CC genotype) are significantly associated with PTC initiation via engaging in the regulation of HOTAIR expression.…”

Section: Introductionsupporting

confidence: 83%

Current research on head and neck cancer-associated long noncoding RNAs

et al. 2017

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Head and neck cancers (HNC) are one of the ten leading cancers worldwide, including a range of malignant tumors arising from the upper neck. Due to the complex mechanisms of HNC and lack of effective biomarkers, the 5-year survival rate of HNC has been low and the mortality rate has been high in recent decades. Long noncoding RNAs (lncRNAs), noncoding RNAs longer than 200 bps, are a focus of current cancer research, closely related to tumor biology. LncRNAs have been revealed to be aberrantly expressed in various types of HNC, and the dysregulated lncRNAs participate in HNC progression and induce malignant behavior by modulating gene expression at diverse levels. This review will focus on the functions and molecular mechanisms of dysregulated lncRNAs in HNC tumorigenesis and progression, as well as their diagnostic, therapeutic or prognostic implications in HNC.

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Section: Introductionsupporting

confidence: 83%

Current research on head and neck cancer-associated long noncoding RNAs

et al. 2017

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“…The expression of HOTAIR is upregulated in human TC cells compared with normal human thyroid cells. Moreover, knockdown of HOTAIR significantly inhibited cell growth and invasion in TPC-1 and SW579 human TC [46]. …”

Section: Homeobox Transcript Antisense Rnamentioning

confidence: 99%

Long Non-Coding RNAs in Thyroid Cancer: Implications for Pathogenesis, Diagnosis, and Therapy

et al. 2019

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Thyroid cancer is a rare malignancy and accounts for less than 1% of malignant neoplasms in humans; however, it is the most common cancer of the endocrine system and responsible for most deaths from endocrine cancer. Long non-coding (Lnc)RNAs are defined as non-coding transcripts that are more than 200 nucleotides in length. Their expression deregulation plays an important role in the progress of cancer. These molecules are involved in physiologic cellular processes, genomic imprinting, inactivation of chromosome X, maintenance of pluripotency, and the formation of different organs via changes in chromatin, transcription, and translation. LncRNAs can act as a tumor suppressor genes or oncogenes. Several studies have shown that these molecules can interact with microRNAs and prevent their binding to messenger RNAs. Research has shown that these molecules play an important role in tumorigenicity, angiogenesis, proliferation, migration, apoptosis, and differentiation. In thyroid cancer, several lncRNAs (MALAT1, H19, BANCR, HOTAIR) have been identified as contributing factors to cancer development, and can be used as novel biomarkers for early diagnosis or even treatment. In this article, we study the newest lncRNAs and their role in thyroid cancer.

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“…In recent years, increasing evidence suggested that the HOTAIR is highly expressed in a wide array of tumor types. 12,15 Multiple studies have demonstrated that the HOTAIR played significant Figure 5. Increase the HOTAIR levels contributed to rapid growth of PTC by negative regulation of the miR-488-5p expression.…”

Section: Discussionmentioning

confidence: 99%

LncRNA HOTAIR Influences the Growth, Migration, and Invasion of Papillary Thyroid Carcinoma via Affection on the miR-488-5p/NUP205 Axis

Xia

2020

Technol Cancer Res Treat

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Objective: The study was aim to investigate the effect of HOX transcript antisense RNA (HOTAIR) on the growth, migration, and invasion of papillary thyroid carcinoma (PTC) and its underlying mechanisms. Methods: Cell growth, invasion, and migration was respectively investigated using the MTT assay, trans-well assay, and wound healing assay. The expression of genes and proteins was respectively determined by Western blot analysis and RT-PCR experiments. Results: It was demonstrated that high expression of HOTAIR in PTC cells (BCPAP) and tissues resulted in fast tumor growth and poor survival time of the PTC-bearing mice models. Moreover, overexpression of HOTAIR leaded to markedly enhanced proliferation, migration, and invasion of BCPAP cells. Increase the levels of HOTAIR in BCPAP cells signally down-regulated the miR-488-5p levels which was able of inhibiting the growth rate, increasing the apoptosis rate, and decreasing the invasion/migration ability of BCPAP cells. Further studies indicated that HOTAIR promoted BCPAP cell growth, invasion, and migration mainly through regulating the miR-488-5p/NUP205 axis and the levels of Bcl-2 as well. Conclusion: HOTAIR promoted the growth, migration, and invasion of papillary thyroid carcinoma mainly through regulating the miR-488-5p/NUP205 axis.

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HOTAIR is a promising novel biomarker in patients with thyroid cancer

Cited by 35 publications

References 23 publications

Current research on head and neck cancer-associated long noncoding RNAs

Current research on head and neck cancer-associated long noncoding RNAs

Long Non-Coding RNAs in Thyroid Cancer: Implications for Pathogenesis, Diagnosis, and Therapy

LncRNA HOTAIR Influences the Growth, Migration, and Invasion of Papillary Thyroid Carcinoma via Affection on the miR-488-5p/NUP205 Axis

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