There is growing concern about sustainable and equitable adaptation in climate change hotspots, commonly understood as locations that concentrate high climatic variability, societal vulnerability, and negative impacts on livelihood systems. Emphasizing gender within these debates highlights how demographic, socio-economic and agro-ecological contexts mediate the experiences and outcomes of climate change. Drawing on data from 25 qualitative case studies across three hotspots in Africa and Asia, analysed using Qualitative Comparative Analysis, we show how and in what ways women's agency, or the ability to make meaningful choices and strategic decisions, contributes to adaptation responses. We find that environmental stress is a key depressor of women's agency even when household structures and social norms are supportive, or legal entitlements available. These findings have implications for the effective implementation of multilateral agreements such as the United Nations Framework Convention on Climate Change, Sendai Framework on Disaster Risk Reduction, and the Sustainable Development Goals.Sustainable, equitable, and effective adaptation is critical in climate change hotspots, locations where climatic shifts, social structures, and livelihood sensitivity converge to exacerbate vulnerability 1,2 . Entrenched social structures create power relations that shape women's and men's experiences of vulnerability through access to resources, divisions of work, and cultural norms around mobility and decision-making, all of which determine adaptive capacity 6,10-21 . Involving trade-offs at every level 12,[22][23][24] , these contextual factors not only shape vulnerabilities but also create possibilities for adaptation 25 .When examining gendered vulnerability and the way in which it is manifest in unequal patriarchal systems, women's agency has emerged as key to realising adaptive capacity, but remains understudied 11 . Drawing on feminist arguments to move beyond simplistic framings of actors in terms of active or passive, victims or perpetrators 7,26,27 , we conceptualise agency as the ability to make meaningful choices and strategic decisions 28 . It can take multiple forms, from bargaining and negotiation to subversion and resistance 29 , varying across institutional sites and scales, and drawing differentially on available material or social resources 28 . Institutions, ranging from the micro (household) and meso (community) level, to the more macro-levels of markets and states 30 , interact and intersect with each other, often intensifying or reproducing inequalities. The rules and norms they establish, can be formal or informal, complementary or competing 31 , giving specific meaning to particular activities, resources and relationships. In the context of climate action, while some research explores the role of social capital, especially women's groups, for instance, in supporting women's agency 32,33 , a nuanced institutional analysis, linking women's agency and its implications for adaptive capacity remains miss...