The spread of SARS-CoV2 new variants increased the number of subjects in home isolation and quarantine. The aim of this study was to assess the compliance with COVID-19 home isolation rules for 32 subjects in home care in Marche Region, Italy. The results showed that subjects in home isolation were better informed about isolation rules (p=0.007) than those who were in quarantine. They had lower educational level (p <0.001) and none/single income (p <0.001) and higher rate of clinical manifestation.The education for a safe quarantine should be strengthened widely, especially among disadvantaged subjects.