How aphid alarm pheromone can control aphids: a review

Bushra, S.; Tariq, Muhammad

doi:10.1080/03235408.2013.851331

Cited by 4 publications

(4 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The LC 50 values confirmed that the activity of L 7 is comparable to that of the lead compound IV‐3. In contrast, the activities of L 2 –L 6 were strongly lower, indicating that when the aromatic group of Phe 2 is retained, the substituent on the benzene ring (Cl, –NO 2 , –OH, –OCH 3 ) has a strong negative impact on the activity, unless the substituent is a robust electron‐withdrawing group like –CF 3 ( L 7 ). This result suggests that the introduced substituents interact with surrounding amino acid residues, changing the conformation of the peptide chain, which is not conducive to the formation of β‐turns and hugely reduces the activity.…”

Section: Resultsmentioning

confidence: 99%

“…As one of the most abundant and destructive pests in agriculture, aphids cause significant damage to crops due to their plant sap‐taking and the vectoring of plant pathogenic viruses. The control of aphids is significant for protecting crops and reducing agricultural losses 1,2 . At present, the most effective method to control aphids is chemical insecticides, 3 but these brought many insecticide resistance problems in the past decades and issues to harm nontarget organisms, especially bees 4–8 .…”

Section: Introductionmentioning

confidence: 99%

“…The control of aphids is significant for protecting crops and reducing agricultural losses. 1,2 At present, the most effective method to control aphids is chemical insecticides, 3 but these brought many insecticide resistance problems in the past decades and issues to harm nontarget organisms, especially bees. [4][5][6][7][8] Recently, it has been discovered that the application of some neonicotinoid insecticides led to a population decrease of bees.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A novel bee‐friendly peptidomimetic insecticide: Synthesis, aphicidal activity and 3D‐QSAR study of insect kinin analogs at Phe² modification

Xin-Ling

Zhang

et al. 2022

Pest Management Science

View full text Add to dashboard Cite

BACKGROUND: As one of the most abundant and destructive pests in agriculture, aphids cause significant damage to crops due to their sap-taking and as virus vectors. Chemical insecticides are the most effective method to control aphids, but they bring insecticide resistance problems and harm nontarget organisms, especially bees, therefore the search for novel eco-friendly aphid control agents with low bee toxicity is urgent. Insect kinins are a class of small neuropeptides that control important functions in insects. In our previous study, we found insect kinin analog IV-3 has good aphicidal activity and the location of the aromatic ring on the side chain of Phe 2 is the key to the formation of the ⊎-turn resulting in the biological activity of insect kinin analogs. However, there are few studies on insect kinin Phe 2 substitution and modification, and its structure-activity relationship is still unclear.RESULTS: In this project, 44 insect kinin analogs with the Phe 2 modification, replacing it with different natural or unnatural amino acids, were designed and synthesized based on the lead IV-3 to explore the role of the Phe 2 residues. Bioassays with soybean aphids of Aphis glycines indicated that nine analogs have better aphicidal activity than the lead IV-3. In particular, compound L 25 exhibits excellent aphicidal activity (LC 50 = 0.0047 mmol L −1 ) and has low toxicity to bees. Furthermore, a reliable three-dimensional quantitative structure-activity relationship (3D-QSAR) was established to produce a helpful clue that introducing hydrophobic groups away from the backbone chain is beneficial to improve aphicidal activity.CONCLUSION: The residue Phe 2 of insect kinin analogs is the key position and has a significant impact on the activity. L 25 has a high toxicity for aphids, while a low toxicity to bees, and therefore can be considered as a lead compound to develop new biosafe aphid control agents. Finally, we provide a useful 3D-QSAR model as theoretical guidance for further structural optimization.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A novel bee‐friendly peptidomimetic insecticide: Synthesis, aphicidal activity and 3D‐QSAR study of insect kinin analogs at Phe² modification

Xin-Ling

Zhang

et al. 2022

Pest Management Science

View full text Add to dashboard Cite

show abstract

“…Aphids are among the most abundant and destructive insect pests, which damage plants not only by sucking phloem sap, secreting honeydew to develop plant sooty moulds, but by transmitting plant viruses 1 . The annual worldwide crop losses due to aphids are estimated at hundreds of millions of dollars 2 . Most aphids will release alarm pheromone to warn their conspecifics of potential threats when attacked by natural enemies, and the main component of the alarm pheromone of many aphid species is the sesquiterpene, ( E )-β-farnesene (EβF) 3 – 5 , which is secreted by cornicles and has been used for control of aphids 3 , 6 , 7 .…”

Section: Introductionmentioning

confidence: 99%

Host plants and obligate endosymbionts are not the sources for biosynthesis of the aphid alarm pheromone

Sun

2017

Sci Rep

View full text Add to dashboard Cite

(E)-β-farnesene (EβF) is the major component of the alarm pheromone of many aphid species, but where EβF is synthesized in aphids is only partly understood. There are at least three most possible sources for the alarm pheromone: host plants, aphid obligate endosymbiont and aphids themselves. Here we eliminated the possibility of host plants and the obligate endosymbiont Buchnera aphidicola as the sources for EβF released by aphids. We excluded the possible effects of host plants on EβF biosynthesis by rearing aphids on non-plant diets. Both the diet-reared aphids, including the cotton aphid Aphis gossypii and the green peach aphid Myzus persicae, could still release EβF based on solid-phase micro-extraction combined with gas chromatography-mass spectrometer analysis. Meanwhile, we treated host aphids with antibiotics to fully eliminate Buchnera bacteria. Though the treatment seriously affected the development and fecundity of host aphids, the treated aphids could still release EβF, and there was no significant difference in the EβF concentration as per the aphid weight under different rearing conditions. Taken together, our experimental results suggest that host plants and obligate endosymbionts are not the sources for EβF released by aphids, indicating that it is most probably the aphid itself synthesizes the alarm pheromone.

show abstract

How aphids find their host plants, and how they don't

Döring

2014

Annals of Applied Biology

139

117

View full text Add to dashboard Cite

There is a considerable interest in trying to understand how aphids find their host plants because they are a major cause of economic losses in agricultural and horticultural production systems. Indeed, the specific behavioural sequences during host finding by aphids are one of the main reasons for their prominent role as vectors of plant pathogenic viruses. This paper reviews the visual and olfactory stimuli involved in host‐finding behaviour of aphids, both basic and applied aspects are covered. Although controlling aphids by manipulation of visual and olfactory stimuli involved in host finding and host selection can be highly successful, as shown by research, most of these measures can still be further optimised and adoption in practice is currently limited. Research therefore needs to address some critical open questions, including (a) the effects of visual contrasts on aphid behaviour; (b) the specific responses of aphids to ultraviolet (UV) light during different stages in host finding; (c) the quantification of behavioural sequences in the field and (d) the response of aphid behaviour to plant diversity at varying spatial scales; further, (e) a much more comprehensive coverage of aphid taxa and aphid ecological groups is needed in host‐finding related research to uncover ecological principles underlying this critical behaviour.

show abstract

How aphid alarm pheromone can control aphids: a review

Cited by 4 publications

References 51 publications

A novel bee‐friendly peptidomimetic insecticide: Synthesis, aphicidal activity and 3D‐QSAR study of insect kinin analogs at Phe² modification

A novel bee‐friendly peptidomimetic insecticide: Synthesis, aphicidal activity and 3D‐QSAR study of insect kinin analogs at Phe² modification

Host plants and obligate endosymbionts are not the sources for biosynthesis of the aphid alarm pheromone

How aphids find their host plants, and how they don't

Contact Info

Product

Resources

About

How aphid alarm pheromone can control aphids: a review

Cited by 4 publications

References 51 publications

A novel bee‐friendly peptidomimetic insecticide: Synthesis, aphicidal activity and 3D‐QSAR study of insect kinin analogs at Phe2 modification

A novel bee‐friendly peptidomimetic insecticide: Synthesis, aphicidal activity and 3D‐QSAR study of insect kinin analogs at Phe2 modification

Host plants and obligate endosymbionts are not the sources for biosynthesis of the aphid alarm pheromone

How aphids find their host plants, and how they don't

Contact Info

Product

Resources

About

A novel bee‐friendly peptidomimetic insecticide: Synthesis, aphicidal activity and 3D‐QSAR study of insect kinin analogs at Phe² modification

A novel bee‐friendly peptidomimetic insecticide: Synthesis, aphicidal activity and 3D‐QSAR study of insect kinin analogs at Phe² modification