How are cancer and connective tissue diseases related to sarcoidosis?

Chopra, Amit; Judson, Marc A.

doi:10.1097/mcp.0000000000000186

Cited by 24 publications

(23 citation statements)

References 72 publications

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“…Granulomas may become fibrotic and calcified and may be confused with lung cancer on radiographic images; however, granulomas are not neoplastic (Borczuk 2012). There is limited evidence for a causal association between sarcoidosis and the development of lung cancer (Artinian and Kvale 2004; Bonifazi et al 2015; Chopra & Judson 2015). …”

Section: Hypotheses On the Mechanistic Events Related To Genotoxicitymentioning

confidence: 99%

Evaluating the mechanistic evidence and key data gaps in assessing the potential carcinogenicity of carbon nanotubes and nanofibers in humans

Kuempel

Jaurand

Møller

et al. 2016

Critical Reviews in Toxicology

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In an evaluation of carbon nanotubes (CNTs) for the IARC Monograph 111, the Mechanisms Subgroup was tasked with assessing the strength of evidence on the potential carcinogenicity of CNTs in humans. The mechanistic evidence was considered to be not strong enough to alter the evaluations based on the animal data. In this paper, we provide an extended, in-depth examination of the in vivo and in vitro experimental studies according to current hypotheses on the carcinogenicity of inhaled particles and fibers. We cite additional studies of CNTs that were not available at the time of the IARC meeting in October 2014, and extend our evaluation to include carbon nanofibers (CNFs). Finally, we identify key data gaps and suggest research needs to reduce uncertainty. The focus of this review is on the cancer risk to workers exposed to airborne CNT or CNF during the production and use of these materials. The findings of this review, in general, affirm those of the original evaluation on the inadequate or limited evidence of carcinogenicity for most types of CNTs and CNFs at this time, and possible carcinogenicity of one type of CNT (MWCNT-7). The key evidence gaps to be filled by research include: investigation of possible associations between in vitro and early-stage in vivo events that may be predictive of lung cancer or mesothelioma, and systematic analysis of dose–response relationships across materials, including evaluation of the influence of physico-chemical properties and experimental factors on the observation of nonmalignant and malignant endpoints.

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Section: Hypotheses On the Mechanistic Events Related To Genotoxicitymentioning

confidence: 99%

Evaluating the mechanistic evidence and key data gaps in assessing the potential carcinogenicity of carbon nanotubes and nanofibers in humans

Kuempel

Jaurand

Møller

et al. 2016

Critical Reviews in Toxicology

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“…Some reports suggested a significant relationship between sarcoidosis and Sjogren's Syndrome, systemic sclerosis and autoimmune thyroid disease. Judson et al, proposed that the association could develop based on some genetic, environmental and/or immunologic associations (5,6). However there is no epidemiological analysis concerning those associations.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, it was determined that the isolated organ involvement of sarcoidosis (37% of the total cases) could be meaningfully more frequent in the patients who previously diagnosed with connective tissue disease (5). Chopra et al suggested that the long term connective tissue disease could lead to the granulomatous lesion that could be falsely diagnosed as sarcoidosis but rather a "sarcoid like" granulomatosis inflammation secondary to their long standing connective tissue disorders (6). Therefore, all the alternative diagnosis should be excluded before making the certain diagnosis of sarcoidosis.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Some constellations of clinical signs or symptoms are almost pathognomonic for sarcoidosis, including bilateral hilar nodal enlargement as an isolated clinical finding, erythema nodosum with bilateral hilar adenopathy (Lofgren Syndrome), and uveitis combined with fever plus parotiditis (Heerfordt Syndrome). Excluding Lofgren's and Heerfordt's Syndromes, the diagnosis of sarcoidosis requires a tissue biopsy confirming granulomatous inflammation and exclusion of known causes of other granulomatous disease (5,6). Sarcoidosis like CTDs is a multisystem disease that may involve almost any organ system; therefore, it results in various clinical manifestations, sometimes similar to those observed in various CTDs.…”

Section: Literature Reviewmentioning

confidence: 99%

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Sarcoidosis and autoimmune disorders. A case report and review of the literature

Ozkan¹

2015

SOB

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SummarySarcoidosis is a multisystem disease of unknown etiology characterized by clusters of non-necrotizing granulomas and distortion of surrounding tissue. Although some patients are asymptomatic, sarcoidosis can cause a wide range of signs and symptoms often mimicking autoimmune rheumatologic disorders. Combined sarcoidosis and autoimmune disorders is uncommon as a result of either an University Hospital database analysis and literature review. However, given the high prevalence of autoimmunity in the general population, clinicians should be alerted to correctly diagnose and manage patients suspected to have both sarcoidosis and autoimmune disorders. KEY WORDS: sarcoidosis, autoimmunity, connective tissue disease. IntroductionSarcoidosis is a systemic inflammatory disorder that involves multiple tissues and is characterized by a non-caseating granulomatous reaction (1). Despite the etiology is not well understood, there are cellular immune system activation and nonspecific inflammatory response similar to some rheumatologic disease which are considered to play an important role in the pathogenesis (2). Sarcoidosis has been reported in all races and ethnic groups with a marked variations. People from different ages can be affected, but it is particularly sighted among the young adults whose ages range from 20 to 40, with possibly a second peak © C I C E d i z i o n i I n t e r n a z i o n a l i both legs together with the appearance of multiple skin papules. A skin biopsy revealed noncaseating epithelioid genulomas, consistent with the diagnosis of sarcoid granulomatosis dermatitis. Then, the patient started a treatment with oral prednisolone tablets (initially 0.75mg/kg body weight then tapering) showing a complete recovery of both skin lesions and leg sign and symptoms. Recognition of cutaneous sarcoid lesions was important in our patient because they provided a visible clue to the contribution of sarcoidosis for patient symptoms. Nevertheless, the diagnosis of cutaneous lesions in a patient with RA and sarcoidosis may be misleading because lesions can exhibit many different morphologies common to both diseases. Literature reviewSarcoidosis is a T helper 1 (Th1) mediated granulomatous disease, with unknown etiology, involving more than one organ. Sarcoidosis may mimic a number of rheumatic diseases or may coexist side by side. It can commonly present with clinical findings that are indicative of vasculitis and spondyloarthritis or connective tissue diseases, including both primary Sjogren's Syndrome, Systemic Lupus Erythematosus, rheumatoid arthritis, and sarcoidosis (1). Some constellations of clinical signs or symptoms are almost pathognomonic for sarcoidosis, including bilateral hilar nodal enlargement as an isolated clinical finding, erythema nodosum with bilateral hilar adenopathy (Lofgren Syndrome), and uveitis combined with fever plus parotiditis (Heerfordt Syndrome). Excluding Lofgren's and Heerfordt's Syndromes, the diagnosis of sarcoidosis requires a tissue biopsy confirming granulomatous inflammat...

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“…It should not surprise therefore that definitive diagnosis is very difficult to obtain in some occasions, and these considerations are even more true if both conditions (e.g., sarcoidosis and malignant conditions) are associated in the same patient. Several studies have demonstrated that sarcoidosis can be a risk factor for malignant degeneration, where continuous inflammatory process represents the leading mechanism [15][16][17]. A correct diagnosis is therefore essential and biopsy is necessary to demonstrate non-caseating granulomas.…”

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confidence: 99%