How breast cancer chemotherapy increases the risk of leukemia: Thoughts about a case of diffuse large B-cell lymphoma and leukemia after breast cancer chemotherapy

Zhang, Bin; Zhang, Xia; Li, Minghuan; Kong, Li; Deng, Xiaoqin; J, Yu

doi:10.1080/15384047.2016.1139233

Cited by 12 publications

(16 citation statements)

References 9 publications

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“…However, we used "2 nd to 1 st " malignancy ratio to show that leukemia (6.0) and prostate cancer (3.0) have more frequently appeared after the first cancer compared to the rest of the second MN (for instance, lung cancer was relatively rare consequence of previous malignancy). Increased "2 nd to 1 st " ratio for leukemia as a second cancer in this study supports the notion that leukemia can also be promoted by conditions related to cancer treatment process [12]. Regarding prostate cancer, this assumption is consistent with the latest studies on the risk assessment of prostate cancer after radiation therapy [13].…”

Section: Discussionsupporting

confidence: 91%

Previous Malignancy as a Risk Factor for the Second Solid Cancer in a Cohort of Nuclear Workers

Осипов

Sokolnikov

2021

SciMed. J.

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This paper describes the results of epidemiological analysis of a cohort of nuclear workers hired at the main facilities of “Mayak” Production Association located in the city of Ozyorsk in Southern Urals of the Russian Federation. Previous malignancy as a risk factor for second cancer in a cohort of 22,373 workers occupationally exposed to ionizing radiation has been analyzed in a retrospective study with more than 60 years of follow-up. Information on main radiation and non-radiation risk factors (attained age, sex, tobacco smoking), as well as the dose of exposure to occupational ionizing radiation has been obtained for the analysis using the data from cancer register as well as other main population registries created in Epidemiological Laboratory of Southern Urals Biophysics Institute. Poisson’s regression realized in the “Amfit” module of “Epicure” statistical package has been applied for risk analysis. Excess relative risk per 1 Gy of absorbed dose of external gamma radiation and internal alpha radiation has been calculated using linear model. Among the 2,471 cancer cases accumulated in the study cohort to the end of follow-up 6.4% of second cancer cases have been diagnosed among workers occupationally exposed to protracted external gamma- and internal alpha radiation. The relative risk of second cancer (except for non-melanoma skin cancer) among nuclear workers with previously diagnosed cancer was about 4 times higher after a decade compared with those cancer patients who had single cancer only. The results showed that previous malignancy along with main non-radiation factors is statistically significant carcinogenic risk factor among nuclear workers exposed to protracted occupational radiation. Doi: 10.28991/SciMedJ-2021-0301-2 Full Text: PDF

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Section: Discussionsupporting

confidence: 91%

Previous Malignancy as a Risk Factor for the Second Solid Cancer in a Cohort of Nuclear Workers

Осипов

Sokolnikov

2021

SciMed. J.

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“…[ 30 , 31 ] Radiotherapy and chemotherapy also involve in the development of subsequent malignancies. Radiotherapy/chemotherapy is related to myelodysplasia and acute myeloid leukemia (tMDS/AML), [ 11 , 32 – 34 ] lymphoma, [ 35 ] soft tissue sarcoma [ 36 ] and skin tumors, [ 37 ] and so on. Other cancer related pathologies included virus infection, [ 38 ] metabolism disorders, [ 39 ] and genetic susceptibility, [ 40 ] etc.…”

Section: Discussionmentioning

confidence: 99%

Problems to affect long-term survival for breast cancer patients

Liu

Feng

et al. 2018

Medicine

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“…In fact, after surgery plus chemotherapy, there is an increased risk of developing LPDs, marrow neoplasms (MNs) 11 , which allows us to understand how B-LPD developed in this patient. Though the most prevalent hematological cancers associated with treatment are acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), treatment-associated lymphomas sometimes occur 10,12 but are clinically rare 13,14 . Adjuvant therapies for early-stage breast cancer include anthracyclines (epirubicin and doxorubicin), alkylating agents (cyclophosphamide), antimetabolites (methotrexate and 5-FU), and taxanes (docetaxel and paclitaxel) 15 , which have been demonstrated to increase the 10-year hematological cancer risk by 0.5% 16 .…”

Section: Discussionmentioning

confidence: 99%

B-cell lymphoma as well as breast cancer contributes to the development of hemophagocytic lymphohistiocytosis: A rare case report

Zhou

Yin

Chang

et al. 2021

Preprint

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BackgroundHemophagocytic lymphohistiocytosis (HLH), which is also known as hemophagocytic syndrome (HPS), can be caused by various factors leading to the reactive proliferation of lymphocytes as well as tissues and cells and the release of inflammatory cytokines, which then impair vital organs. Hemophagocytic lymphohistiocytosis, especially malignancy-associated HLH, which is difficult to differentiate from other diseases in the early stage because of its nonspecific and overlapping manifestations, has a high mortality rate once it occurs. Cases of hemophagocytic lymphohistiocytosis triggered by both solid tumors and lymphomas have rarely been reported before. There is still no consensus regarding the first-line treatment for HLH in adults. More attention should be paid to its early diagnosis and treatments.Case presentationA 55-year-old woman who had undergone thyroidectomy in 2014, left mastectomy for left breast cancer in 2013 and twelve rounds of chemotherapy had continuous fever approximately twenty days prior to admission. Tumor cells were found in her right axillary lymph node aspiration smear in the hospital on January 23. The patient was first diagnosed with pneumonia and treated with antibiotics, with little effectiveness. The etiology of fever remained unclear after a series of examinations, which excluded infection and rheumatic diseases and led us to consider noninfectious fever. Continuous hyperpyrexia, pancytopenia and continuous decreases in blood platelets and plasma albumin were suggestive of HLH. Then, bone marrow puncture confirmed this finding and indicated B-cell lymphoma invading the bone. Unexpectedly, during this time, the disease progressed rapidly, culminating in the patient’s death, and no examinations or treatments were performed in time.ConclusionsSecondary hemophagocytic lymphohistiocytosis can be caused by various factors. Malignancy-associated HLH (M-HLH), as a kind of secondary HLH, is difficult to distinguish from primary cancer due to its nonprominent clinical manifestation, thus leading to misdiagnosis and delayed treatment.

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How breast cancer chemotherapy increases the risk of leukemia: Thoughts about a case of diffuse large B-cell lymphoma and leukemia after breast cancer chemotherapy

Cited by 12 publications

References 9 publications

Previous Malignancy as a Risk Factor for the Second Solid Cancer in a Cohort of Nuclear Workers

Previous Malignancy as a Risk Factor for the Second Solid Cancer in a Cohort of Nuclear Workers

Problems to affect long-term survival for breast cancer patients

B-cell lymphoma as well as breast cancer contributes to the development of hemophagocytic lymphohistiocytosis: A rare case report

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