How cationic lipids transfer nucleic acids into cells and across cellular membranes: Recent advances

Rehman, Zia Ur; Zuhorn, Inge S.; Hoekstra, Dick

doi:10.1016/j.jconrel.2012.12.014

Cited by 172 publications

(134 citation statements)

References 153 publications

Supporting

Mentioning

131

Contrasting

Unclassified

Order By: Relevance

“…Positively charged nanoparticles have a high affinity to negatively charged proteoglycans expressed on the surface of most cells, resulting in more efficient adsorptive endocytosis, compared with neutral and negatively charged nanoparticles. Of note, heparan sulfate proteoglycans, comprise transmembrane proteins termed syndecans, are considered major binding sites for cationic delivery vehicles [78]. However, such cationic nanoparticles are not able to take advantage of systemic administration due to non-specific interactions with negatively charged blood components before reaching target cells.…”

Section: Design Criteria To Overcome Intracellular Barriersmentioning

confidence: 99%

Recent progress in development of siRNA delivery vehicles for cancer therapy

Kim

Miyata

et al. 2016

Advanced Drug Delivery Reviews

376

305

View full text Add to dashboard Cite

Recent progress in RNA biology has broadened the scope of therapeutic targets of RNA drugs for cancer therapy. However, RNA drugs, typically small interfering RNAs (siRNAs), are rapidly degraded by RNases and filtrated in the kidney, thereby requiring a delivery vehicle for efficient transport to the target cells. To date, various delivery formulations have been developed from cationic lipids, polymers, and/or inorganic nanoparticles for systemic delivery of siRNA to solid tumors. This review describes the current status of clinical trials related to siRNA-based cancer therapy, as well as the remaining issues that need to be overcome to establish a successful therapy. It, then introduces various promising design strategies of delivery vehicles for stable and targeted siRNA delivery, including the prospects for future design.

show abstract

Section: Design Criteria To Overcome Intracellular Barriersmentioning

confidence: 99%

Recent progress in development of siRNA delivery vehicles for cancer therapy

Kim

Miyata

et al. 2016

Advanced Drug Delivery Reviews

376

305

View full text Add to dashboard Cite

show abstract

“…Since the structure of the cationic lipid-DNA assemblies affect their interactions with cells (Allen and Cullis 2013;ur Rehman et al 2013;Dan and Danino 2014), the structural effects described for DODAB and diC14-amidine should be taken in account when planning biotechnological applications, such as delivery systems.…”

Section: Dnamentioning

confidence: 99%

“…Establishment of their safety then led to cationic membranes being then employed as carriers of proteins and nucleic acids to eukaryotic cells (Zelphati et al 2001;ur Rehman et al 2013). This technical development enabled the study of gene function, silencing and therapy (Caracciolo and Amenitsch 2012) and stimulated the development of dozens of lipids with different cationic headgroups and hydrophobic moieties (ur Rehman et al 2013;Junquera and Aicart 2016;Majzoub et al 2016). In this review we focus on membranes formed by two cationic lipids: dioctadecyldimethylammonium bromide (DODAB) and diC14-amidine (Fig.…”

Section: Introductionmentioning

confidence: 99%

Structural insights on biologically relevant cationic membranes by ESR spectroscopy

et al. 2017

View full text Add to dashboard Cite

Cationic bilayers have been used as models to study membrane fusion, templates for polymerization and deposition of materials, carriers of nucleic acids and hydrophobic drugs, microbicidal agents and vaccine adjuvants. The versatility of these membranes depends on their structure. Electron spin resonance (ESR) spectroscopy is a powerful technique that employs hydrophobic spin labels to probe membrane structure and packing. The focus of this review is the extensive structural characterization of cationic membranes prepared with dioctadecyldimethylammonium bromide or diC14-amidine to illustrate how ESR spectroscopy can provide important structural information on bilayer thermotropic behavior, gel and fluid phases, phase coexistence, presence of bilayer interdigitation, membrane fusion and interactions with other biologically relevant molecules.

show abstract

“…The strategy explored involves the incorporation of cationic lipid within the surfactant layer surrounding the nanoemulsion. Cationic nanoparticles are generally more effectively taken up by cells owing to the electrostatic interaction between nanoparticles and the negatively charged glycoproteins abundant on cell membranes [20]. Since ICG-loaded nanoemulsions exhibit a negative surface charge owing to the anionic property of ICG [16], it was assumed that incorporation of a cationic lipid would increase the cellular uptake of nanoemulsions by switching the surface charge to a positive value.…”

Section: Introductionmentioning

confidence: 99%