How Closely Does Induced Agarwood’s Biological Activity Resemble That of Wild Agarwood?

Ma, Sheng; Huang, Manqin; Fu, Yunlin; Qiao, Min; Li, Yingjian

doi:10.3390/molecules28072922

Cited by 6 publications

(5 citation statements)

References 35 publications

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“…According to one study, siloxanes have been well-acknowledged to possess substantial antibacterial and antioxidant effects [ 54 ]. Thus, the compounds (di-n-decyl sulfone, cyclohexano, 2,4-dimethyl-, salicylic acid, diethyl bis (trimethylsilyl) ester, carbonic acid, methyl octyl ester, phenol, 2,6-bis (1,1-dimethylethyl)-4-methyl-, methylcarbamate, etc.,) found in the HWE of AAJ could prevent diseases such as aging, cancer, cardiovascular disease, inflammation, and other disorders that are dangerous to humans' health occurred due to the overabundance of free radicals in our body [ 108 ]. In addition, phenolic compounds can influence biological processes such as cell cycle control, apoptosis induction, and antiproliferation, which are primarily mediated through interactions between receptors and ligands [ 92 ].…”

Section: Resultsmentioning

confidence: 99%

Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds

Gebreyohannes,

Sbhatu

2023

International Journal of Analytical Chemistry

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Secondary metabolites are hidden gems in mushrooms. Understanding these secondary metabolites’ biological and pharmacological effects can be aided by identifying them. The purpose of this work was to profile the mycochemical components of the extracts of Auricularia auricula judae, Microporus xanthopus, Termitomyces umkowaani, Trametes elegans, and Trametes versicolor to comprehend their biological and pharmacological capabilities. Mushroom samples were collected from Kenya’s Arabuko–Sokoke and Kakamega National Reserved Forests and identified using morphological and molecular techniques. Chloroform, 70% ethanol, and hot water solvents were used to extract the mycochemical components. Gas chromatography mass spectrometry (GC-MS) was used to analyze the chloroform, 70% ethanol, and hot water extracts of all the species examined. A total of 51 compounds were isolated from all extracts and classified as carboxylic acids, esters, phenols, fatty acids, alcohol, epoxides, aldehydes, fatty aldehydes, isoprenoid lipids, and steroids. Tetracosamethyl-cyclododecasiloxane (18.90%), oleic acid (72.90%), phenol, 2, 6-bis (1, 1-dimethylethyl)-4-methyl-, and methylcarbamate (26.56%) were all found in high concentrations in A. auricular judae, M. xanthopus, T. umkowaani, T. elegans, and T. versicolor, respectively. Fatty acids make up the majority of the compounds isolated from the T. elegans chloroform extract and the T. umkowaani 70% ethanol extract, respectively. Particularly, these fatty acids play crucial roles in the anti-inflammatory, hypocholesterolemic, anticancer, and antibiofilm formation activities. These bioactive elements indicate that the extracts of five wild mushrooms may be reliable sources of secondary metabolites for therapeutic development. Therefore, additional research is required to comprehend the usefulness of these chemicals in many functional areas and to improve the present understanding of macrofungi.

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Section: Resultsmentioning

confidence: 99%

Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds

Gebreyohannes,

Sbhatu

2023

International Journal of Analytical Chemistry

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“…Antioxidant Activity and Enzyme-Inhibitory Activity 3.6.1. Antioxidant Activity According to Ma et al's method [45], various quantities of extracts were employed in the diphenylpicrophenylhydrazine (DPPH • ), 2,2 ′ -Azinobis-(3-ethylbenzthiazoline-6sulphonate (ABTS •+ ) radical scavenging test. In parallel, VC was used as a positive control.…”

Section: Response Surface Optimizationmentioning

confidence: 99%

“…A modified version of Ma et al's [45] approach was employed. After the sample solutions were prepared using extract, an assay was carried out to determine whether the anti-acetylcholine ester activity was inhibited.…”

Section: Inhibitory Activity Of Acetylcholinesterasementioning

confidence: 99%

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Optimization of Extraction Process and Analysis of Biological Activity of Flavonoids from Leaves of Cultivated ‘Qi-Nan’ Agarwood

Li,

Wei,

et al. 2024

Molecules

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Currently, the planting of ‘Qi-Nan’ is continuously increasing, yet a substantial amount of ‘Qi-Nan’ leaves have not been properly exploited. To improve the ‘Qi-Nan’ tree ’s utilization value, ‘Qi-Nan’ leaves were used as a raw material. An ultrasound-assisted method was performed to obtain the flavonoids from the ’Qi-Nan’ leaves, followed by optimization of the extraction factors using a one-way and response surface methodology to enhance the extraction of flavonoids. Subsequently, the composition of the flavonoids, as well as their bioactive abilities, were analyzed by ultra-high-performance liquid chromatography–mass spectrometry (UHPLC-MS) and in vitro activity testing methods. The findings demonstrated that a 1:50 material-to-liquid ratio, 60% ethanol concentration, and ultrasound-assisted extraction time of 30 min were the ideal procedures for extracting flavonoids (flavonoid content: 6.68%). Meanwhile, the ‘Qi-Nan’ leaves possessed the antioxidant and medicinal potential to prevent diabetes and Alzheimer ’s disease, as evidenced by the semi-inhibitory concentrations (IC50 values) of flavonoid extracts for scavenging DPPH• free radicals, scavenging ABTS•+ free radicals, inhibiting acetylcholinesterase, and inhibiting α-glucosidase, which were 12.64 μg/mL, 66.58 μg/mL, 102.31 μg/mL, and 38.76 μg/mL, respectively, which indicated that the ‘Qi-Nan’ leaves possessed the properties of antioxidant and medicinal potential for the prevention of Alzheimer ’s disease and diabetes.

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“…According to one study, siloxanes have been well-acknowledged to possess substantial antibacterial and antioxidant efects [54]. Tus, the compounds (di-n-decyl sulfone, cyclohexano, 2,4-dimethyl-, salicylic acid, diethyl bis (trimethylsilyl) ester, carbonic acid, methyl octyl ester, phenol, 2,6-bis (1,1-dimethylethyl)-4methyl-, methylcarbamate, etc.,) found in the HWE of AAJ could prevent diseases such as aging, cancer, cardiovascular disease, infammation, and other disorders that are dangerous to humans' health occurred due to the overabundance of free radicals in our body [108]. In addition, phenolic compounds can infuence biological processes such as cell cycle control, apoptosis induction, and antiproliferation, which are primarily mediated through interactions between receptors and ligands [92].…”

Section: Gc-ms Analysis Of Auricularia Auricula-judae-aajmentioning

confidence: 99%

Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds

Gebreyohannes¹,

Sbhatu²

2023

Preprint

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Mushrooms are unexploited treasures of secondary metabolites. Analysis of the chemical constituents of these mushrooms would be necessary for the assessment of their pharmacological and biological activities. This study aimed at profiling of mycochemical constituents of five wild mushroom extracts thereby understanding their biological and pharmacological properties. Mushrooms were collected from Arabuko-Sokoke and Kakamega National Reserved Forests, Kenya. Specimens were identified by both morphological and molecular methods. Bioactive compounds were extracted using chloroform, 70% ethanol, and hot water solvents. Chloroform, 70% ethanol, and hot water extracts of Auricularia auricula-judae, Microporus xanthopus, Termitomyces umkowaani, Trametes elegans, and Trametes versicolor were determined using gas chromatography and mass spectrometry (GC-MS). From all extracts, a total of fifty-one (51) compounds were identified and grouped into carboxylic acids, esters, phenols, fatty acids, alcohol, epoxides, aldehyde, fatty aldehyde, isoprenoid lipids, and steroid. Of the total compounds, Oleic acid (72.90%) from Trametes elegans was detected abundantly. Most of the compounds obtained from the chloroform extract of Trametes elegans and 70% ethanol extract of T. umkowaani are fatty acids. The identified compounds have revealed many biological and pharmacological activities such as antimicrobial, antioxidant, antimalarial, anti-inflammatory, insecticidal, anti-helminthic, larvicidal, vasodilator, antihypertensive, hepatoprotective, anticancer, antidiabetic, antifertility anti-diuretic, antiasthma, antifouling, anti-dermatophytic, antispasmodic, anti-hypocholesterolemic, nematicide, pesticide, immunostimulant, antiarthritic, and antihistaminic. These fatty acids are particularly playing important roles in the anti-inflammatory, hypocholesterolemic anticancer, and anti-biofilm formation activities. The presence of these bioactive components suggests that the extracts of five wild mushrooms could be good sources of secondary metabolites for drug discovery.

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How Closely Does Induced Agarwood’s Biological Activity Resemble That of Wild Agarwood?

Cited by 6 publications

References 35 publications

Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds

Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds

Optimization of Extraction Process and Analysis of Biological Activity of Flavonoids from Leaves of Cultivated ‘Qi-Nan’ Agarwood

Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds

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