2016
DOI: 10.1055/s-0035-1570357
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How Cool It Is: Targeted Temperature Management for Brain Protection Post–Cardiac Arrest

Abstract: Neurological recovery often determines outcome in patients resuscitated after cardiac arrest. Temperature control as a neuroprotective strategy has become standard of care. The first randomized trials showing improved neurological outcomes in patients treated with hypothermia with a target temperature of 33°C over a decade ago led to the inclusion of this intervention in practice guidelines and the broad adoption of hypothermia protocols across the world. More recently, large randomized trials showed no differ… Show more

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Cited by 4 publications
(5 citation statements)
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References 59 publications
(84 reference statements)
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“…The data show clear beneficial effects of CT, with complete absence of epithelial thickening already at a moderate cooling temperature (30 °C). Previous studies aiming to identify optimal temperatures for CT after cardiac arrest or traumatic brain injury have not been able to show advantages of considerably decreased temperatures [ 24 , 25 ]. On the contrary, a mild to moderately decreased temperature seems to be best tolerated and yield best long-term outcomes.…”
Section: Discussionmentioning
confidence: 99%
“…The data show clear beneficial effects of CT, with complete absence of epithelial thickening already at a moderate cooling temperature (30 °C). Previous studies aiming to identify optimal temperatures for CT after cardiac arrest or traumatic brain injury have not been able to show advantages of considerably decreased temperatures [ 24 , 25 ]. On the contrary, a mild to moderately decreased temperature seems to be best tolerated and yield best long-term outcomes.…”
Section: Discussionmentioning
confidence: 99%
“…In 2010, the Consensus Conference in Brussels adopted the document "Hypothermia in Stroke: A Call to Action 2010" [28], which established a research program on the use of hypothermia in patients with acute ischemic stroke, which was updated in 2015-2016 [31,34,[41][42][43]. In January 2018, the American Heart Association (AHA) and the American Stroke Association (ASA) updated guidelines for the early management of patients with acute ischemic stroke, which were presented at the International Stroke Conference 2018 on January 24-26 in Los Angeles [45]. The AHA/ASA recommendations were based on an analysis of data from more than 400 peer-reviewed articles published in highly rated journals.…”
Section: Epidemiology and Prevention Of Ischemic Strokementioning
confidence: 99%
“…The AHA/ASA recommendations were based on an analysis of data from more than 400 peer-reviewed articles published in highly rated journals. The main works have been reviewed by a panel of stroke management experts and are currently the most comprehensive recommendations for the treatment of ischemic stroke published since 2013 [45]. An unchanging, but extremely important recommendation remains the need for quick pre-hospital action when the first symptoms of a stroke appear.…”
Section: Epidemiology and Prevention Of Ischemic Strokementioning
confidence: 99%
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“…Neuroprotective therapies have been implemented with the intention to stabilize primary lesions, prevent or reduce secondary lesions, and improve neurological outcomes and survival rates [9,10]. Hypothermia is one of the most promising and effective neuroprotective methods, mainly because it reduces cellular metabolic activity [11][12][13]; however, other mechanisms [14][15][16][17] also contribute to the observed benefits. Therapeutic hypothermia and targeted temperature management have been recommended by the American Heart Association [18][19][20] and The Cochrane Collaboration [21] for preserving cerebral function of patients surviving resuscitation after cardiac arrest.…”
Section: Introductionmentioning
confidence: 99%