How do nitrated lipids affect the properties of phospholipid membranes?

Oliveira, Maria C.; Yusupov, Maksudbek; Bogaerts, Annemie; Cordeiro, Rodrigo M.

doi:10.1016/j.abb.2020.108548

Cited by 12 publications

(23 citation statements)

References 46 publications

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“…Recently, we showed that nitrated lipids (also produced by free radicals) considerably increase the membrane permeability. 35 Boonnoy and co-workers observed the formation of water defects induced by both lipid aldehydes and lipid hydroperoxides, where full pore formation was observed only in the bilayer consisting of lipid aldehydes. At 50% oxidation with lipid aldehydes, the pores were stable.…”

Section: ■ Introductionmentioning

confidence: 99%

Lipid Oxidation: Role of Membrane Phase-Separated Domains

Oliveira

Yusupov

Bogaerts

et al. 2021

J. Chem. Inf. Model.

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Lipid oxidation is associated with several inflammatory and neurodegenerative diseases, but many questions to unravel its effects on biomembranes are still open due to the complexity of the topic. For instance, recent studies indicated that phase-separated domains can have a significant effect on membrane function. It is reported that domain interfaces are “hot spots” for pore formation, but the underlying mechanisms and the effect of oxidation-induced phase separation on membranes remain elusive. Thus, to evaluate the permeability of the membrane coexisting of liquid-ordered (Lo) and liquid-disordered (Ld) domains, we performed atomistic molecular dynamics simulations. Specifically, we studied the membrane permeability of nonoxidized or oxidized homogeneous membranes (single-phase) and at the Lo/Ld domain interfaces of heterogeneous membranes, where the Ld domain is composed of either oxidized or nonoxidized lipids. Our simulation results reveal that the addition of only 1.5% of lipid aldehyde molecules at the Lo/Ld domain interfaces of heterogeneous membranes increases the membrane permeability, whereas their addition at homogeneous membranes does not have any effect. This study is of interest for a better understanding of cancer treatment methods based on oxidative stress (causing among others lipid oxidation), such as plasma medicine and photodynamic therapy.

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Section: ■ Introductionmentioning

confidence: 99%

Lipid Oxidation: Role of Membrane Phase-Separated Domains

Oliveira

Yusupov

Bogaerts

et al. 2021

J. Chem. Inf. Model.

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“…[ 69 ] Membrane consisting of combined nitro‐oxidized lipid products may protect the transient pore formation in the presence of oxidized lipids. [ 70 ]…”

Section: General Anticancer Mechanism In Vitromentioning

confidence: 99%

“…[69] Membrane consisting of combined nitro-oxidized lipid products may protect the transient pore formation in the presence of oxidized lipids. [70] For the second case, complex intracellular pathways may be involved after CAP treatment. One pathway may overturn the redox balance by compromising on the intracellular antioxidant system.…”

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confidence: 99%

On the selective killing of cold atmospheric plasma cancer treatment: Status and beyond

Yan

Horkowitz

Wang

2021

Plasma Processes & Polymers

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Compared with many chemotherapy and radiotherapy modalities, selective killing of cancer cells is a pivotal feature of cold atmospheric plasma (CAP).Understanding its underlying mechanism will build the foundation of CAPbased cancer treatment. Additionally, we provided forward-looking thinking to extend the definition of selectivity from conventional cases involving a single-cell line to a coculture case. Finally, the newly established physically based treatment strategy provides unprecedented visions to realize selectivity beyond the previously established concepts based on reactive species and direct killing effect.

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“…We have recently shown that nitrated lipids increase the permeability of phospholipid membranes to water by a factor three compared to oxidized lipids [34]. Nevertheless, no systematic modeling studies have been conducted to investigate the effect of nitrated lipids on the biomembrane permeability to other species, namely RONS.…”

Section: Introductionmentioning

confidence: 99%