How Do Phenolic Compounds React toward Superoxide Ion? A Simple Electrochemical Method for Evaluating Antioxidant Capacity

René, Alice; Abasq, Marie-Laurence; Hauchard, Didier; Hapiot, Philippe

doi:10.1021/ac101854w

Cited by 89 publications

(60 citation statements)

References 65 publications

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“…Superoxide radical anion scavenging assay of KPEt showed IC 50 value of 34.77 ± 4.23 μ g/mL while chrysin (reference) showed IC 50 value of 42.54 ± 5.10 μ g/mL. Superoxide radical anion (O 2 •− ) is generated by number of metabolic processes and has ability to react with the cell and induce cellular damage and various diseases [ 34 ]. Antioxidant capacity of various flavonoids is primarily due to scavenging of superoxide anion [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

Antioxidant, Hepatoprotective Potential and Chemical Profiling of Propolis Ethanolic Extract from Kashmir Himalaya Region Using UHPLC-DAD-QToF-MS

Wali

Avula

Ali

et al. 2015

BioMed Research International

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The aim of this study was to examine hepatoprotective effect of ethanolic extract of propolis (KPEt) from Kashmir Himalaya against isoniazid and rifampicin (INH-RIF) induced liver damage in rats. Hepatic cellular injury was initiated by administration of INH-RIF combination (100 mg/kg) intraperitoneal (i.p.) injection for 14 days. We report the protective effects of KPEt against INH-RIF induced liver oxidative stress, inflammation, and enzymatic and nonenzymatic antioxidants. Oral administration of KPEt at both doses (200 and 400 mg/kg body weight) distinctly restricted all modulating oxidative liver injury markers and resulted in the attenuation of INH-RIF arbitrated damage. The free radical scavenging activity of KPEt was evaluated by DPPH, nitric oxide, and superoxide radical scavenging assay. The components present in KPEt identified by ultra high performance liquid chromatography diode array detector time of flight-mass spectroscopy (UHPLC-DAD-QToF-MS) were found to be flavonoids and phenolic acids. The protective efficacy of KPEt is possibly because of free radical scavenging and antioxidant property resulting from the presence of flavonoids and phenolic acids.

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Section: Resultsmentioning

confidence: 99%

Antioxidant, Hepatoprotective Potential and Chemical Profiling of Propolis Ethanolic Extract from Kashmir Himalaya Region Using UHPLC-DAD-QToF-MS

Wali

Avula

Ali

et al. 2015

BioMed Research International

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“…However, although the complete β-NPT photodegradation was not observed in the ATR-IR spectra after using A-E-MHP, we infer that the O 2 •─ species can also directly degrade the organic molecules to obtain non-radical products (reactions 6 and 7). 29,30 Hence, the decrease of C/C o relative concentration of β-NPT can be reached:…”

Section: Band Structure Of the Hot-injection And Anion-exchange Mixedmentioning

confidence: 99%

Unravelling the Photocatalytic Behavior of All-Inorganic Mixed Halide Perovskites: The Role of Surface Chemical States

Gualdrón‐Reyes

Rodríguez‐Pereira

González

et al. 2019

ACS Appl. Mater. Interfaces

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Within the most mesmerizing materials in the world of optoelectronics, mixed halide perovskites (MHP) have been distinguished due to the tunability of their optoelectronic properties, balancing both the light harvesting efficiency and charge extraction into highly efficient solar devices. This feature has drawn the attention of analogous hot-topics as photocatalysis for carrying out more efficiently the degradation of organic compounds. However, the photo-oxidation ability of perovskite does not only depend on its excellent light-harvesting properties, but also on the surface chemical environment provided during its synthesis. Accordingly, we studied the role of surface chemical states of MHP based nanocrystals (NCs) synthesized by hot-injection (H-I) and anion-exchange (A-E) approaches, on their photocatalytic (PC) activity for the oxidation of β-naphthol as a model system. We concluded that iodide vacancies are the main surface chemical states that facilitate the formation of superoxide ions, O 2 •─ , responsible for the PC activity in A-E-MHP. Conversely, the PC performance of H-I-MHP is related to the appropriate balance between band gap and a highly oxidizing valence band. This work offers new insights on the surface properties of MHP related to their catalytic activity in photochemical applications.

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“…It is indeed now known or in some cases suspected that these radicals play a crucial role in DNA damage and repair (see for example [44][45][46]). The interest for phenolic compounds is also related to their antioxidant properties (47)(48)(49)(50).…”

Section: Introductionmentioning

confidence: 99%

Photoinduced Proton‐Coupled Electron Transfers in Biorelevant Phenolic Systems

Bonin¹,

Robert²

2011

Photochem & Photobiology

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Proton-coupled electron transfer (PCET) reactions have received much attention over the past 10 years, from an experimental as well as from a theoretical point of view. At the heart of many chemical and biological processes, such reactions are of particular interest in energy conversion and enzymatic processes. Among the numerous examples of PCET reactions, photosynthesis and particularly reactions inside the Photosystem II (PSII) subunit, involving a global four electrons and four protons process to perform water oxidation and respiration, is the most emblematic one. This review focuses on the photochemical approaches of PCET reactions involving phenolic molecules. Indeed, a significant part of photochemical PCET studies were conducted on tyrosine or phenol relevant to PSII and charge transport in enzymes. The mechanisms of these reactions, sequential or concerted, with particular emphasis on the influence of pH, temperature, solvent nature and H-bonding pattern are presented based on photochemical techniques and related theoretical analysis.

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How Do Phenolic Compounds React toward Superoxide Ion? A Simple Electrochemical Method for Evaluating Antioxidant Capacity

Abstract: 10) Polyphenols can act as exogenous molecules taking part in the antioxidant defense system of the organism by several mechanisms such as H-donating, metal ion chelating, enzyme inhibition, gene expression regulation, and pro-oxidant pathways: (a) Kashima, M.

Cited by 89 publications

References 65 publications

Antioxidant, Hepatoprotective Potential and Chemical Profiling of Propolis Ethanolic Extract from Kashmir Himalaya Region Using UHPLC-DAD-QToF-MS

Antioxidant, Hepatoprotective Potential and Chemical Profiling of Propolis Ethanolic Extract from Kashmir Himalaya Region Using UHPLC-DAD-QToF-MS

Unravelling the Photocatalytic Behavior of All-Inorganic Mixed Halide Perovskites: The Role of Surface Chemical States

Photoinduced Proton‐Coupled Electron Transfers in Biorelevant Phenolic Systems

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