How does biological sex affect the physiological response to nanomaterials?

Yang, Jung‐Lynn Jonathan; Narayanamurthy, Rukhmani; Yager, Jerome Y.; Unsworth, Larry D.

doi:10.1016/j.nantod.2021.101292

Cited by 8 publications

(4 citation statements)

References 206 publications

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“…Intrinsic contact activation through the interaction of the surface, Factor XII, high-molecular-weight kininogen, and prekallikrein is a known humoral response to artificial materials that leads to thrombus formation [ 42 , 43 ]. Plasma clotting experiments were conducted for bare and engineered MNPs ( Figure 7 , Table 3 ).…”

Section: Resultsmentioning

confidence: 99%

Hemocompatibility of β-Cyclodextrin-Modified (Methacryloyloxy)ethyl Phosphorylcholine Coated Magnetic Nanoparticles

Sharaf

Rowe

et al. 2023

Biomolecules

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Adsorbing toxins from the blood to augment membrane-based hemodialysis is an active area of research. Films composed of β-cyclodextrin-co-(methacryloyloxy)ethyl phosphorylcholine (p(PMβCD-co-MPC)) with various monomer ratios were formed on magnetic nanoparticles and characterized. Surface chemistry effects on protein denaturation were evaluated and indicated that unmodified magnetic nanoparticles greatly perturbed the structure of proteins compared to coated particles. Plasma clotting assays were conducted to investigate the stability of plasma in the presence of particles, where a 2:2 monomer ratio yielded the best results for a given total surface area of particles. Total protein adsorption results revealed that modified surfaces exhibited reduced protein adsorption compared to bare particles, and pure MPC showed the lowest adsorption. Immunoblot results showed that fibrinogen, α1-antitrypsin, vitronectin, prekallikrein, antithrombin, albumin, and C3 correlated with film composition. Hemocompatibility testing with whole blood illustrated that the 1:3 ratio of CD to MPC had a negative impact on platelets, as evidenced by the increased activation, reduced response to an agonist, and reduced platelet count. Other formulations had statistically significant effects on platelet activation, but no formulation yielded apparent adverse effects on hemostasis. For the first time, p(PMβCD-co-MPC)-coated MNP were synthesized and their general hemocompatibility assessed.

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Section: Resultsmentioning

confidence: 99%

Hemocompatibility of β-Cyclodextrin-Modified (Methacryloyloxy)ethyl Phosphorylcholine Coated Magnetic Nanoparticles

Sharaf

Rowe

et al. 2023

Biomolecules

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“…The study of sex differences in nanomedicine is a burgeoning field. We are not the first to consider this topic (Hajipour et al, 2021;Sharifi et al, 2021;Yang et al, 2021;Poley et al, 2022). Here, we will focus on summarizing empirical observations of sex differences in the field of nanomedicine, moving from microscopic to macroscopic length scales, with a particular focus on implications for developing nanoparticle systems in acute brain injury.…”

Section: Sex Differences In Nanomedicinementioning

confidence: 99%

Acute brain injury and nanomedicine: sex as a biological variable

Simmons,

Mihalek,

Bimonte Nelson

et al. 2024

Front. Biomater. Sci.

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Sex as a biological variable has been recognized for decades to be a critical aspect of the drug development process, as differences in drug pharmacology and toxicity in female versus male subjects can drive the success or failure of new therapeutics. These concepts in development of traditional drug systems have only recently begun to be applied for advancing nanomedicine systems that are designed for drug delivery or imaging in the central nervous system (CNS). This review provides a comprehensive overview of the current state of two fields of research - nanomedicine and acute brain injury—centering on sex as a biological variable. We highlight areas of each field that provide foundational understanding of sex as a biological variable in nanomedicine, brain development, immune response, and pathophysiology of traumatic brain injury and stroke. We describe current knowledge on female versus male physiology as well as a growing number of empirical reports that directly address sex as a biological variable in these contexts. In sum, the data make clear two key observations. First, the manner in which sex affects nanomedicine distribution, toxicity, or efficacy is important, complex, and depends on the specific nanoparticle system under considerations; second, although field knowledge is accumulating to enable us to understand sex as a biological variable in the fields of nanomedicine and acute brain injury, there are critical gaps in knowledge that will need to be addressed. We anticipate that understanding sex as a biological variable in the development of nanomedicine systems to treat acute CNS injury will be an important determinant of their success.

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“…Additionally, grafts from males were more degraded at the end of the study (79). The cellular response to nanoparticles has displayed sex differences as well (80). Bharadwaj et al (81) showed in vivo that blood-brain barrier permeability to circulating nanoparticles was heightened in female mice compared with male mice following traumatic brain injury.…”

Section: Matrices and Scaffoldsmentioning

confidence: 99%

Sex as a Biological Variable in Tissue Engineering and Regenerative Medicine

Allen

Ludtka

James

2023

Annu. Rev. Biomed. Eng.

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Although sex differences have been noted in cellular function and behavior, therapy efficacy, and disease incidence and outcomes, the adoption of sex as a biological variable in tissue engineering and regenerative medicine remains limited. Furthering the development of personalized, precision medicine requires considering biological sex at the bench and in the clinic. This review provides the basis for considering biological sex when designing tissue-engineered constructs and regenerative therapies by contextualizing sex as a biological variable within the tissue engineering triad of cells, matrices, and signals. To achieve equity in biological sex within medicine requires a cultural shift in science and engineering research, with active engagement by researchers, clinicians, companies, policymakers, and funding agencies. Expected final online publication date for the Annual Review of Biomedical Engineering, Volume 25 is June 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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How does biological sex affect the physiological response to nanomaterials?

Cited by 8 publications

References 206 publications

Hemocompatibility of β-Cyclodextrin-Modified (Methacryloyloxy)ethyl Phosphorylcholine Coated Magnetic Nanoparticles

Hemocompatibility of β-Cyclodextrin-Modified (Methacryloyloxy)ethyl Phosphorylcholine Coated Magnetic Nanoparticles

Acute brain injury and nanomedicine: sex as a biological variable

Sex as a Biological Variable in Tissue Engineering and Regenerative Medicine

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