How Does the Heart Respond to Aortic Stenosis

Carabello, Blasé A.

doi:10.1161/circimaging.113.001242

Cited by 18 publications

(7 citation statements)

References 31 publications

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“…Another important aspect of severe AS interfering with cerebral autoregulation is chronic cerebral hypoperfusion. Years after the maladaptive myocardial changes begin, the outflow obstruction leads to reduced stroke volume, resulting in loss of cerebral blood flow and the ability to attenuate blood pressure fluctuations (Carabello, 2013 ). Patients with smaller baseline aortic valve areas showed reduced phase improvements after SAVR at low frequencies.…”

Section: Discussionmentioning

confidence: 99%

Changes in cerebral autoregulation and vasoreactivity after surgical aortic valve replacement: a prospective study

Pedro

Costa

Ferreira

et al. 2022

Experimental Physiology

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Surgical aortic valve replacement (SAVR) alters the natural course of severe aortic stenosis (AS). In this study, we aimed to determine the effects of the disease on dynamic cerebral autoregulation and vasoreactivity (VR) and to assess their changes after SAVR. We recruited 23 patients diagnosed with severe AS eligible for SAVR and 15 healthy matched controls. AS patients had lower mean VR to CO 2 (P = 0.005) than controls, but dynamic cerebral autoregulation was preserved.Cerebral haemodynamics showed no significant change after SAVR. Patients with smaller baseline aortic valve areas presented with smaller low frequency phase changes after surgery (P = 0.016). Severe AS does not seem to impact dynamic cerebral autoregulation but does reduce VR to CO 2 . SAVR does not alter cerebral autoregulation nor vasoreactivity.

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Section: Discussionmentioning

confidence: 99%

Changes in cerebral autoregulation and vasoreactivity after surgical aortic valve replacement: a prospective study

Pedro

Costa

Ferreira

et al. 2022

Experimental Physiology

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“…Every heart responds differently to the pressure overload evoked by AS. Therefore, the common classification of the severity of AS based solely on the orifice area and blood flow velocity may be too rough for the individual patient, and the integration of data about the impact of the AS on the LV might be helpful. Attempts in this direction have been made by using blood biomarkers, ECG changes, or sophisticated echo measurements .…”

Section: Discussionmentioning

confidence: 99%

Myocardial dysfunction in patients with aortic stenosis and hypertensive heart disease assessed by MR tissue phase mapping

Knobelsdorff‐Brenkenhoff

Hennig

Menza

et al. 2015

Magnetic Resonance Imaging

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“…Aortic sclerosis can develop into a more serious aortic valve stenosis ( 22 ). Aortic valve stenosis reduces the outflow of blood from the left ventricle, resulting in left ventricular (LV) hypertrophy as a compensatory mechanism to overcome pressure overload ( 23 ). Like the aortic valve, the mitral valve, which guards blood flow against the left atrium to the left ventricle, also shows increased deposition of collagen, lipids, and calcium with ageing.…”

Section: Pathophysiological Changes Associated With Cardiac Ageingmentioning

confidence: 99%

Role of noncoding RNAs in cardiac ageing

Varghese

Schwenke²,

Katare³

2023

Front. Cardiovasc. Med.

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The global population is estimated to reach 9.8 billion by 2050, of which 2.1 billion will comprise individuals above 60 years of age. As the number of elderly is estimated to double from 2017, it is a victory of the modern healthcare system but also worrisome as ageing, and the onset of chronic disease are correlated. Among other chronic conditions, cardiovascular diseases (CVDs) are the leading cause of death in the aged population. While the underlying cause of the age-associated development of CVDs is not fully understood, studies indicate the role of non-coding RNAs such as microRNAs (miRNAs) and long noncoding RNAs (lnc-RNAs) in the development of age-associated CVDs. miRNAs and lnc-RNAs are non-coding RNAs which control gene expression at the post-transcriptional level. The expression of specific miRNAs and lnc-RNAs are reportedly dysregulated with age, leading to cardiovascular system changes and ultimately causing CVDs. Since miRNAs and lnc-RNAs play several vital roles in maintaining the normal functioning of the cardiovascular system, they are also being explored for their therapeutic potential as a treatment for CVDs. This review will first explore the pathophysiological changes associated with ageing. Next, we will review the known mechanisms underlying the development of CVD in ageing with a specific focus on miRNA and lnc-RNAs. Finally, we will discuss the therapeutic options and future challenges towards healthy cardiac ageing. With the global ageing population on the rise, this review will provide a fundamental understanding of some of the underlying molecular mechanisms of cardiac ageing.

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How Does the Heart Respond to Aortic Stenosis

Cited by 18 publications

References 31 publications

Changes in cerebral autoregulation and vasoreactivity after surgical aortic valve replacement: a prospective study

Changes in cerebral autoregulation and vasoreactivity after surgical aortic valve replacement: a prospective study

Myocardial dysfunction in patients with aortic stenosis and hypertensive heart disease assessed by MR tissue phase mapping

Role of noncoding RNAs in cardiac ageing

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