2014
DOI: 10.1371/journal.pone.0085379
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How Early Can Myocardial Iron Overload Occur in Beta Thalassemia Major?

Abstract: BackgroundMyocardial siderosis is the most common cause of death in patients with beta thalassemia major(TM). This study aimed at investigating the occurrence, prevalence and severity of cardiac iron overload in a young Chinese population with beta TM.Methods and ResultsWe analyzed T2* cardiac magnetic resonance (CMR), left ventricular ejection fraction (LVEF) and serum ferritin (SF) in 201 beta TM patients. The median age was 9 years old. Patients received an average of 13 units of blood per year. The median … Show more

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Cited by 41 publications
(51 citation statements)
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“…Although we do not have data on hepatic iron, liver enzyme data suggested that children with ALT levels of >50 IU/l are at twofold higher risk of development of IFG. Although we did not measure hepatic iron in this study, the value of liver iron over cardiac T2* as a predictive risk factor for development of endocrinopathies was small . Perhaps this is attributable to the fact that cardiac iron stores were emptied slower than liver iron stores after chelation therapy.…”
Section: Discussionmentioning
confidence: 88%
“…Although we do not have data on hepatic iron, liver enzyme data suggested that children with ALT levels of >50 IU/l are at twofold higher risk of development of IFG. Although we did not measure hepatic iron in this study, the value of liver iron over cardiac T2* as a predictive risk factor for development of endocrinopathies was small . Perhaps this is attributable to the fact that cardiac iron stores were emptied slower than liver iron stores after chelation therapy.…”
Section: Discussionmentioning
confidence: 88%
“…This analysis excluded 4 subjects who had received less than 6 years of transfusions, considered inadequate time for cardiac iron loading (21). Myocardial iron (T2* < 20 ms) was present in 0%, 22%, and 46% of subjects with ΔmtDNA 4977 frequency < 20, 20–40, and > 40/1 × 10 7 mtDNA, respectively ( P = 0.025, χ 2 test).…”
Section: Resultsmentioning
confidence: 99%
“…Ancak etkili transfüzyon ve şelasyon tedavisine rağmen talasemiden ölümlerin en sık nedeni kardiyak komplikasyonlardır 38 . Etkin şelasyon tedavisi almayan veya ileride tedaviye dirençli sol ventrikül yetmezliği gelişme riskinin yüksek olduğu miyokardiyal demir birikimi bulunan hastalarda semptomlar gelişmeden önce demir birikimi gösterilerek morbidite ve mortalite azaltılabilir 39,40 .…”
Section: Kardiak Komplikasyonlarunclassified
“…Miyokardda demir birikiminden dolayı oluşan kalp yetmezliği sıklıkla 20'li yaşlarda ortaya çıkar. Ölümlerin %70'i demir yükünün yol açtığı kardiyak dekompansasyon sonucudur 39 . Demir kalp kasındaki, miyositlerde depolanır.…”
Section: Kardiak Komplikasyonlarunclassified