How gamma and electron-beam irradiations modulate phenolic profile expression in Melissa officinalis L. and Melittis melissophyllum L.

Pereira, Eliana; António, Amílcar L.; Barreira, João C.M.; Santos‐Buelga, Celestino; Barros, Lillian; Ferreira, Isabel C.F.R.

doi:10.1016/j.foodchem.2017.07.113

Cited by 13 publications

(8 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The raw material collected from M. melissophyllum is herb rich in phenolic compounds. Among them o-coumaric, protocatechuic, chlorogenic, vanillic, caffeic, syringic, ferulic, sinapic and cinnamic acid, as well as flavonoids, namely apigenin, kaempferol, luteolin, quercetin and myricetin, were earlier reported [10,13,14,25]. According to the study of Skrzypczak-Pietraszek and Pietraszek [14], the dominant flavonoids in M. melissophyllum leaves were cynaroside (from 38.00 to 92.00 mg 100 g −1 DW) and rutin (from 19.0 to 43.0 mg 100 g −1 DW); however, the total content of flavonoids was higher in the leaves than in flowers.…”

Section: Chemical Traitsmentioning

confidence: 95%

Effect of Shading on Development, Yield and Quality of Bastard Balm Herb (Melittis melissophyllum L.)

et al. 2020

View full text Add to dashboard Cite

The aim of the study was to assess the effects of Melittis melissophyllum shading on its development and accumulation of phenolics. Their content (verbascoside, apiin, luteolin-7-O-glucoside, coumarin, 3,4-dihydroxycoumarin, o-coumaric acid 2-O-glucoside as well as o-coumaric, p-coumaric, chlorogenic, caffeic, ferulic and cichoric acid) was determined in the herb using HPLC-DAD. The results showed that the content of abovementioned flavonoids and phenolic acids was highest in plants grown under full sunlight. On the other hand, a higher content of coumarin was observed in shaded plants, especially after the seed-setting stage. A similar tendency was noted for the amount of chlorophyll a and b. The content of hydrogen peroxide and malondialdehyde, the activity of polyphenol oxidase and catalase and the antioxidant capacity of plant extracts (measured using DPPH, ABTS and FRAP assays) were found to be the highest in the plants grown in full sunlight. However, the plants grown in moderate (30%) shade were found to thrive best.

show abstract

Section: Chemical Traitsmentioning

confidence: 95%

Effect of Shading on Development, Yield and Quality of Bastard Balm Herb (Melittis melissophyllum L.)

et al. 2020

View full text Add to dashboard Cite

show abstract

“…A total of 20 compounds were identified taking into account the identification pattern previously performed by Pereira et al, 25 using an infusion of M. officinalis. Hydroxycinnamic acid derivatives were the main class of phenolic compounds present in the extract, specifically rosmarinic acid (caffeic acid dimer) was the most abundant compound present.…”

Section: Phenolic Characterization Of Melissa Officinalismentioning

confidence: 99%

Melissa officinalisL. ethanolic extract inhibits the growth of a lung cancer cell line by interfering with the cell cycle and inducing apoptosis

et al. 2018

View full text Add to dashboard Cite

Melissa officinalis is a plant from the family Lamiaceae, native in Europe particularly in the Mediterranean region. Given our interest in identifying extracts and compounds capable of inhibiting tumor cell growth, and given the antioxidant content and the high consumption of Melissa officinalis in Portugal, this study aimed to test the tumor cell growth inhibitory activity of five different extracts of this plant (aqueous, methanolic, ethanolic, hydromethanolic and hydroethanolic) in three human tumor cell lines: MCF-7, AGS and NCI-H460. All extracts decreased cell growth in all cell lines in a concentration-dependent manner. The ethanolic extract was the most potent one, presenting a GI 50 concentration of approximately 100.9 µg mL −1 in the NCI-H460 lung cancer cells. This extract was characterized by LC-DAD-ESI/MS regarding its phenolic composition, revealing rosmarinic acid as the most abundant compound. The GI 75 concentration of this extract affected the cell cycle profile of these cells. In addition, both the GI 50 and the GI 75 concentrations of the extract induced cellular apoptosis. Moreover, treatment of NCI-H460 cells with this extract caused a decrease in pro-caspase 3 and an increase in p53 levels. This study emphasizes the relevance of the study of natural products as inhibitors of tumor cell growth.

show abstract

“…The literature concerning phenolic compounds in M. melissophyllum is much scarce. So far, coumarin and some phenolic acids have been identified in the herb, namely o-coumaric, protocatechuic, chlorogenic, vanillic, caffeic, syringic, ferulic, sinapic, and cinnamic acids [10][11][12]. Among the flavonoids present in this plant, apigenin, kaempferol, luteolin, quercetin, and myricetin have been reported [13].…”

Section: Introductionmentioning

confidence: 92%

Chemical Diversity of Bastard Balm (Melittis melisophyllum L.) as Affected by Plant Development

et al. 2020

View full text Add to dashboard Cite

The phytochemical diversity of Melittis melissophyllum was investigated in terms of seasonal changes and age of plants including plant organs diversity. The content of phenolics, namely: coumarin; 3,4-dihydroxycoumarin; o-coumaric acid 2-O-glucoside; verbascoside; apiin; luteolin-7-O-glucoside; and o-coumaric; p-coumaric; chlorogenic; caffeic; ferulic; cichoric acids, was determined using HPLC-DAD. Among these, luteolin-7-O-glucoside, verbascoside, chlorogenic acid, and coumarin were the dominants. The highest content of flavonoids and phenolic acids was observed in 2-year-old plants, while coumarin in 4-year-old plants (272.06 mg 100 g–1 DW). When considering seasonal changes, the highest content of luteolin-7-O-glucoside was observed at the full flowering, whereas verbascoside and chlorogenic acid were observed at the seed-setting stage. Among plant organs, the content of coumarin and phenolic acids was the highest in leaves, whereas verbascoside and luteolin-7-O-glucoside were observed in flowers. The composition of essential oil was determined using GC-MS/GC-FID. In the essential oil from leaves, the dominant was 1-octen-3-ol, whilst from flowers, the dominant was α-pinene.

show abstract

How gamma and electron-beam irradiations modulate phenolic profile expression in Melissa officinalis L. and Melittis melissophyllum L.

Cited by 13 publications

References 28 publications

Effect of Shading on Development, Yield and Quality of Bastard Balm Herb (Melittis melissophyllum L.)

Effect of Shading on Development, Yield and Quality of Bastard Balm Herb (Melittis melissophyllum L.)

Melissa officinalisL. ethanolic extract inhibits the growth of a lung cancer cell line by interfering with the cell cycle and inducing apoptosis

Chemical Diversity of Bastard Balm (Melittis melisophyllum L.) as Affected by Plant Development

Contact Info

Product

Resources

About