The swelling effect of high-pressure carbon dioxide (CO 2) in coal seam is obvious. In the restrained deep formation, it is converted to stress acting on the wellbore and the caprock. The action stress is concentrated near the wellbore and poses a threat to the cement-formation interface. Due to interface failure to micro-annulus, wellbore integrity will be lost and this will have an impact on carbon dioxide-enhanced coalbed methane recovery (CO 2-ECBM) and storage. In this paper, the pseudo-steady pressure distribution and steady pressure distribution of CO 2 injection process were established after considering the change in permeability of coal seam injected with high-pressure supercritical CO 2 , and the vertical stress distribution model was derived. A one-dimensional radial numerical simulation formed by iterative method was established. A model for calculating the failure length at the cement-formation interface is obtained, and the shear stress and debonding length at the interface at various injection rates and times are calculated. The results show that the shear stress on the cement-formation interface has the maximum magnitude on the height of the interface between coal seam and caprock. The shear stress generated by coal swelling may break the fragile cement-formation interface into a narrow debonding interface. The injection rate has an influence on the interface failure length. For the same total injection amount, low injection rate is beneficial to protect the cement-formation interface integrity. This study provides a reference for the design of maximum injection speed for CO 2-ECBM and storage to avoid leakage.