Background
Ambulatory blood pressure (ABP) is a better predictor of adverse cardiovascular events than office BP (OBP). Due to the extensive literature on the “white coat effect”, it is widely believed that ABP tends to be lower than OBP, with statements to this effect in JNC VII. However, recent evidence suggests that the difference varies systematically with age.
Methods
We searched PubMed to identify population studies, published before April 2009, which assessed office BP and either ABP or home BP. Because of significant heterogeneity in the outcomes, random effects models were used for the meta-analyses.
Results
OBP increased with age more steeply than awake ABP. OBP became higher than awake systolic/diastolic ABP at the age of 51.3/42.7 years in men (13 studies, N=3562) and 51.9/42.3 years in women (11 studies, N=2585). In the data in which OBP and HBP were measured (8 studies, N=4916), OBP was higher than HBP at all ages. In the data in which OBP, awake ABP and HBP were all measured (2 studies, N=895), awake ABP was higher than HBP at younger ages, becoming similar at the older age.
Conclusion
OBP tends to be higher than awake ABP only after age 50 for systolic and age 45 for diastolic, but is lower than ABP at younger ages; in contrast OBP tends to exceed HBP at all ages.