The development and use of information and communications technology (ICT) are growing at a rapid speed across the world. ICT has been the cause for new types of work arrangements, such as virtual organizations, virtual teams, teleworking, etc. Virtual teams provide organizations with competitive advantage by enabling them to hire talented people across the world and eliminating the need for physical availability in the office. However, one major issue hindering the productivity of the virtual team is knowledge sharing. The lack of proper knowledge sharing between team members may cause organizations to fail with regards to the implementation of successful strategies. The research into understanding knowledge sharing in virtual teams (VT) in the Middle East is lacking. While such studies have been done in the United States and Europe, the Middle East has been overlooked. In this study, the authors assume that there are some specific behavioral aspects of VT in the Middle East that create the need for specific scientific solutions. Accordingly, this study was conducted in the Middle East in order to gain scientific knowledge on the region’s specificity. The objective of this article is to create a model for the evaluation of the effect on knowledge sharing in virtual teams in the Middle East. For analysis, the selection of companies includes United Arab Emirates (UAE)-based companies in the IT industry whose businesses engage in VT. The results show that the following factors have a direct effect on knowledge sharing in VT: Culture, motivation, conflict, ICT, trust, and leadership. Conversely, the results do not demonstrate that language has any impact on knowledge sharing. The methodology used is as follows: Literature review, survey methods, and structural equation modeling.