How is mechanobiology involved in bone regenerative medicine?

Pisheh, Hossein Rayat; Ansari, Mojtaba; Eslami, Hossein

doi:10.1016/j.tice.2022.101821

Cited by 7 publications

(4 citation statements)

References 177 publications

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“…Mechanical signaling is considered an important and effective pathophysiological and physiological process in cells and cartilage tissue. Movement is important for maintaining healthy cartilage and preventing OA ( Hodgkinson et al, 2022 ; Pisheh et al, 2022 ). Articular cartilage (from the subchondral bone to the joint surface) is divided into three deep, middle, and superficial parts ( Poole et al, 2001 ).…”

Section: Mechanosignaling In Cartilage Treatmentmentioning

confidence: 99%

A review of advanced hydrogels for cartilage tissue engineering

Ansari,

Darvishi,

Sabzevari

2024

Front. Bioeng. Biotechnol.

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With the increase in weight and age of the population, the consumption of tobacco, inappropriate foods, and the reduction of sports activities in recent years, bone and joint diseases such as osteoarthritis (OA) have become more common in the world. From the past until now, various treatment strategies (e.g., microfracture treatment, Autologous Chondrocyte Implantation (ACI), and Mosaicplasty) have been investigated and studied for the prevention and treatment of this disease. However, these methods face problems such as being invasive, not fully repairing the tissue, and damaging the surrounding tissues. Tissue engineering, including cartilage tissue engineering, is one of the minimally invasive, innovative, and effective methods for the treatment and regeneration of damaged cartilage, which has attracted the attention of scientists in the fields of medicine and biomaterials engineering in the past several years. Hydrogels of different types with diverse properties have become desirable candidates for engineering and treating cartilage tissue. They can cover most of the shortcomings of other treatment methods and cause the least secondary damage to the patient. Besides using hydrogels as an ideal strategy, new drug delivery and treatment methods, such as targeted drug delivery and treatment through mechanical signaling, have been studied as interesting strategies. In this study, we review and discuss various types of hydrogels, biomaterials used for hydrogel manufacturing, cartilage-targeting drug delivery, and mechanosignaling as modern strategies for cartilage treatment.

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Section: Mechanosignaling In Cartilage Treatmentmentioning

confidence: 99%

A review of advanced hydrogels for cartilage tissue engineering

Ansari,

Darvishi,

Sabzevari

2024

Front. Bioeng. Biotechnol.

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“…One of the key characteristics of bone scaffolds is their capacity to endorse or intensify bone differentiation, a process that ultimately results in the generation of new mineral bone tissue. Bone extracellular matrix (ECM) synthesis and mineralisation are linked to this procedure [81]. Since rat osteogenic repair is higher than human levels, future studies using this model of osteoporosis should concentrate on animals whose bone structure is similar to that of humans.…”

Section: Bone Repair and Remodellingmentioning

confidence: 99%

A Short Review on Chondroitin Sulphate and Its Based Nanomaterials for Bone Repair and Bone Remodelling Applications

Divya,

Vijayakumar,

Chen

2023

J. Compos. Sci.

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Joint damage is a major symptom of osteoarthritis, a degenerative disease that worsens over time. The purpose of this review was to assess the effectiveness and safety of nanomaterials as an alternative to the widely used methods. Due to its poor regenerative and self-healing properties, cartilage repair after lesions or debilitating disease is a major clinical issue. Here, we use the organometallic chemistry identity of chondroitin sulphate to repair cartilage lesions by creating a nano-elemental particle through electrostatic interactions. As an integral part of the extracellular matrix, chondroitin sulphate (CS) is shown to improve osteogenesis in this review. The injectability of hydrated cement products was greatly improved by the addition of CS, but there was no discernible change in their phase, morphology, apparent porosity, or compressive strength. This review article provides a thorough analysis of the results from the use of nanocomposites in orthopaedic drug delivery and bone remodelling engineering.

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“…Still, most have problems such as incompatibility in the biological environment, lack of antibacterial properties, and proper degradability [8,9]. A suitable wound dressing should have the following characteristics [7,[10][11][12]: Appropriate speed of water evaporation to prevent infection and bacterial accumulation in the wound, appropriate permeability, and the ability to absorb uids and nutrients to prevent the growth of bacteria in the wound, creating a barrier to prevent the penetration of microorganisms and infection to the wound site, antibacterial properties to prevent the growth of microbes in the dressing area. Restoration or replacement of damaged tissue has always been one of the main concerns of biological scientists.…”

Section: Introductionmentioning

confidence: 99%

Design of an electrospun polyvinyl alcohol (PVA)/chitosan/curcumin based- wound dressing containing titania nanotubes (TNT)

Eslami,

Kabiri,

Ansari

et al. 2024

Preprint

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Burn wounds are one of the most significant causes of morbidity around the world. Burn wound healing and skin tissue regeneration still have serious and considerable challenges. This study applies the electrospinning method to make PVA-chitosan-curcumin wound dressing containing titania nanotubes with 0.5, 1.5, and 3 wt%, following that their physicochemical properties were investigated using scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), and mechanical test. Then, the in vivo effectiveness of the designed wound dressing in the wound healing process in the Wistar rat model was evaluated for two weeks. The most important result of applying the TiO2 nanotube was the improved regeneration of damaged tissues with an appreciable decline in scar formation, skin color anomalies, and accelerated wound healing and contraction.

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How is mechanobiology involved in bone regenerative medicine?

Cited by 7 publications

References 177 publications

A review of advanced hydrogels for cartilage tissue engineering

A review of advanced hydrogels for cartilage tissue engineering

A Short Review on Chondroitin Sulphate and Its Based Nanomaterials for Bone Repair and Bone Remodelling Applications

Design of an electrospun polyvinyl alcohol (PVA)/chitosan/curcumin based- wound dressing containing titania nanotubes (TNT)

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