Prenatal screening programmes have been critiqued for their routine implementation according to clinical rationale without public debate. A new approach, non-invasive prenatal diagnosis (NIPD), promises diagnosis of fetal genetic disorders from a sample of maternal blood without the miscarriage risk of current invasive prenatal tests (e.g. amniocentesis). Little research has investigated the attitudes of wider publics to NIPD. This study used Q-methodology, which combines factor analysis with qualitative comments, to identify four distinct 'viewpoints' amongst 71 UK men and women: 1. NIPD as a new tool in the ongoing societal discrimination against the disabled; 2. NIPD as a positive clinical application offering peace of mind in pregnancy; 3. NIPD as a medical option justified for severe disorders only; and 4. NIPD as a valid expansion of personal choice. Concerns included the 'trivialization of testing' and the implications of commercial/direct-to-consumer tests. Q-methodology has considerable potential to identify viewpoints and frame public debate about new technologies.Running head: Public viewpoints on new non-invasive prenatal genetic tests 3 'Non-invasive prenatal diagnosis (or NIPD) is the term for a new approach to genetic prenatal diagnosis. NIPD technologies are at various stages of development, but as a collective, aim to offer earlier, easier and less risky genetic testing of the fetus through maternal blood with the potential to replace current diagnostic pathways (e.g. for Down's syndrome diagnosis) and widen prenatal testing possibilities (Hahn & Chitty, 2008). NIPD technologies have raised considerable debate within bioethical and social scientific communities, but with little attention within public 1 spheres to date. This paper reports findings from an ESRC funded study of public attitudes towards NIPD. It was conducted in the UK, where prenatal testing is a well-established aspect of obstetric care, and the small amount of media reporting of early NIPD trials has been largely positive.
Non-invasive prenatal diagnosisCurrent screening pathways for common genetic disorders move progressively from noninvasive towards invasive techniques. Non-invasive technologies such as ultrasound are used initially to screen pregnancies. Those identified as 'high risk' are subsequently offered diagnosis through invasive techniques such as amniocentesis or chorionic villus sampling (CVS). These carry a small but significant miscarriage risk (Caughey, Hopkins et al. 2006) and are usually conducted from 15 weeks onwards. One goal of NIPD is to replace this two-step pathway with a one-step early less risky diagnostic test by taking blood from the pregnant woman to analyse the genetic information of the fetus. Non-invasive techniques have been driven by the discovery of 'cell-free fetal DNA' (cffDNA) and RNA (cffRNA) in maternal plasma during pregnancy (Lo, Corbetta et al. 1997). This allows the possibility of obtaining definitive genetic information about the fetus for a limited range of conditions (e.g. ...