How Much Daily Image-guided Volumetric Modulated Arc Therapy Is Useful for Proctitis Prevention With Respect to Static Intensity Modulated Radiotherapy Supported by Topical Medications Among Localized Prostate Cancer Patients?

Ferini, Gianluca; Tripoli, Antonella; Molino, Laura; Cacciola, Alberto; Lillo, Sara; Parisi, Silvana; Umina, Vincenza; Illari, Salvatore Ivan; Marchese, Valentina; Cravagno, Irene Rita; Borzì, Giuseppina Rita; Valenti, Vito

doi:10.21873/anticanres.14981

Cited by 20 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While the first is exclusively devoted to the treatment of brain targets [12], the second is also used for treating extracranial tumors [13]. In recent years, a LINAC-based RT technique-namely Volumetric Modulated Arc Therapy (VMAT), which was typically employed for limiting radiationrelated adverse events in extracranial sites [14,15]-has been enhanced with advanced Treatment Planning Systems (TPS) to plan a simultaneous radiation dose delivery to multiple brain metastases with maximal sparing of healthy tissue, similarly to what is achievable with GK [8]. Regarding the therapeutic index, these two stereotactic techniques constantly confront dosimetric challenges, and no clinical study has yet confirmed a clear benefit of the one over the other [16].…”

mentioning

confidence: 99%

Radiotherapy in Current Neuro-Oncology: There Is Still Much to Reveal

Ferini¹,

Umana

2021

Life

Self Cite

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Radiotherapy in Current Neuro-Oncology: There Is Still Much to Reveal

Ferini¹,

Umana

2021

Life

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, data on RP in an inpatient setting are lacking. As the use of RT continues to increase, physicians are more likely to encounter patients with RP, despite the availability of progressively less toxic radiotherapy techniques [ 11 ]. Therefore, it becomes essential to identify hospitalization characteristics and the disease burden on the US healthcare system.…”

Section: Discussionmentioning

confidence: 99%

Radiation proctitis: predictors of mortality and inpatient outcomes in the United States

Dahiya¹

2021

aog

View full text Add to dashboard Cite

Background We aimed to evaluate the characteristics of hospitalizations for radiation proctitis (RP). Methods The National Inpatient Sample (NIS) was analyzed to identify RP hospitalizations for 2016 and 2017. Outcomes included mortality, predictors of mortality, mean length of stay (LOS), mean total hospital cost (THC), and numerous system-based complications. Results We identified 16,810 adult hospitalizations for RP. On admission, an initial diagnosis of RP was established for only 27.54% of these patients. The mean age was 72.3±0.5 years and 30.2% of the study population was female. Whites made up 68.7% of the study population. Most hospitalizations for RP were at large (51%), urban (93.6%), and teaching (71.1%) hospitals. The inpatient mortality for RP hospitalizations was 1.7%. After adjusting for biodemographic factors, hospitalization characteristics and comorbidities, older age and protein energy malnutrition (PEM) were associated with higher odds of inpatient mortality. The mean LOS and THC for RP hospitalizations were 5.6 days and $53,800, respectively. Inpatient complications associated with RP included acute renal failure (19.7%), sepsis (4.4%), deep vein thrombosis (3.7%), acute respiratory failure (3.3%), and pulmonary embolism (0.7%). Conclusions Inpatient mortality for RP was 1.7%. Older age and PEM were associated with higher odds of inpatient mortality.

show abstract

“…Given that new drugs and the cutting-edge knowledge of subcellular mechanisms may help to prolong survival even among patients progressing to metastatic stage, the delayed CVD risk is real in an increasingly large LBC patient population [ 5 , 6 ]. The past decades have led to great improvements in radiation delivery techniques to reduce treatment toxicities in challenging tumor sites close to radiosensitive organs at risk (OARs) [ 7 , 8 , 9 , 10 ]. As regards the treatment of LBCs, the most promising and popular technique is represented by the deep-inspiration-breath-hold (DIBH) irradiation, which uses the lung expansion to displace the heart silhouette from the posterior edge of the tangential radiation fields (TRFs) [ 11 ] or from the mid-high isodose lines in cases of volumetric modulated arc therapy (VMAT) use [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

A Critical Overview of Predictors of Heart Sparing by Deep-Inspiration-Breath-Hold Irradiation in Left-Sided Breast Cancer Patients

Ferini¹,

Valenti²,

Viola³

et al. 2022

Cancers

Self Cite

View full text Add to dashboard Cite

Radiotherapy represents an essential part of the therapeutic algorithm for breast cancer patients after conservative surgery. The treatment of left-sided tumors has been associated with a non-negligible risk of developing late-onset cardiovascular disease. The cardiac risk perception has especially increased over the last years due to the prolongation of patients’ survival owing to the advent of new drugs and an ever earlier cancer detection through screening programs. Improvements in radiation delivery techniques could reduce the treatment-related heart toxicity. The deep-inspiration-breath-hold (DIBH) irradiation is one of the most advanced treatment approaches, which requires specific technical equipment and uses inspiration to displace the heart from the tangential radiation fields. However, not all patients benefit from its use. Moreover, DIBH irradiation needs patient compliance and accurate training. Therefore, such a technique may be unjustifiably cumbersome and time-consuming as well as unnecessarily expensive from a mere healthcare cost point of view. Hence the need to early select only the true beneficiaries while tailoring more effective heart-sparing techniques for the others and streamlining the workflow, especially in high-volume radiation oncology departments. In this literature overview, we collected some possible predictors of cardiac dose sparing in DIBH irradiation for left breast treatment in an effort to provide an easy-to-consult summary of simple instruments to insiders for identifying patients actually benefitting from this technique. We critically reviewed the reliability and weaknesses of each retrieved finding, aiming to inspire new insights and discussions on this much-debated topic.

show abstract

How Much Daily Image-guided Volumetric Modulated Arc Therapy Is Useful for Proctitis Prevention With Respect to Static Intensity Modulated Radiotherapy Supported by Topical Medications Among Localized Prostate Cancer Patients?

Cited by 20 publications

References 0 publications

Radiotherapy in Current Neuro-Oncology: There Is Still Much to Reveal

Radiotherapy in Current Neuro-Oncology: There Is Still Much to Reveal

Radiation proctitis: predictors of mortality and inpatient outcomes in the United States

A Critical Overview of Predictors of Heart Sparing by Deep-Inspiration-Breath-Hold Irradiation in Left-Sided Breast Cancer Patients

Contact Info

Product

Resources

About