Climate change is having an increasing effect on human society and ecosystems. The United Nations has established 17 sustainable development goals, one of which is to cope with climate change. How to scientifically explore uncertainties and hazards brought about by climate change in the future is crucial. The new Intergovernmental Panel on Climate Change (IPCC) has proposed shared socioeconomic pathways (SSPs) to project climate change scenarios. SSP has been analyzed globally, but how regions and nations respond to the global climate change and mitigation policies is seldom explored, which do not meet the demand for regional environmental assessment and social sustainable development. Therefore, in this paper, we reviewed and discussed how SSPs were applied to regions, and this can be summarized into four main categories: (1) integrated assessment model (IAM) scenario analysis, (2) SSPs-RCPs-SPAs framework scenario analysis, (3) downscaling global impact assessment model, and (4) regional impact assessment model simulation. The study provides alternative ways to project land use, water resource, energy, and ecosystem service in regions, which can carry out related policies and actions to address climate change in advance and help achieve sustainable development.