How Much Hemolysis Is Acceptable When Undertaking Deep Lancing for Finger Stick Derived Capillary Plasma Glucose Measurement?

Heenan, Helen; Lunt, Helen; Chan, Huan; Frampton, Chris

doi:10.1177/1932296816688013

Cited by 5 publications

(6 citation statements)

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“…4 Hemolysis (in the categories "slight," "moderate," or "severe") occurred in over half of the 0.6 mL samples obtained from deep lancing. 2 Aggregating the results quoted in Cembrowski and Füzéry's correspondence describing visible hemolysis in shallow lanced samples from a previously unpublished study, 20 out of 141 "shallow" samples showed visible hemolysis after spinning. 1 Why was the focus of our original correspondence on deep lancing?…”

Section: Letter To the Editormentioning

confidence: 62%

Section: Letter To the Editormentioning

confidence: 99%

“…We are responding to the thoughtful letter by Cembrowski and Füzéry, "Deep Lancing or Over Manipulation," in this issue of the Journal of Diabetes Science and Technology, 1 which was written in response to our initial letter, "How Much Hemolysis Is Acceptable When Undertaking Deep Lancing for Finger Stick Derived Capillary Plasma Glucose Measurement?" 2 The purpose of our initial correspondence was to encourage open sharing of data and insights on the mechanisms and effects of hemolysis, in relation to capillary sample acquisition for plasma glucose measurement. 2 We are therefore pleased that Cembrowski and Füzéry provided new data and also progressed this discussion.…”

Section: Letter To the Editormentioning

confidence: 99%

“…2 The purpose of our initial correspondence was to encourage open sharing of data and insights on the mechanisms and effects of hemolysis, in relation to capillary sample acquisition for plasma glucose measurement. 2 We are therefore pleased that Cembrowski and Füzéry provided new data and also progressed this discussion. 1 Hemolysis appears to be common when collecting capillary "finger stick" samples: We reported hemolysis indices from 42 participants obtained during a previous study.…”

Section: Letter To the Editormentioning

confidence: 99%

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Capillary Samples and Hemolysis: Further Considerations

Heenan¹,

Lunt

Chan³

et al. 2017

J Diabetes Sci Technol

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Section: Letter To the Editormentioning

confidence: 62%

Section: Letter To the Editormentioning

confidence: 99%

Section: Letter To the Editormentioning

confidence: 99%

Section: Letter To the Editormentioning

confidence: 99%

See 2 more Smart Citations

Capillary Samples and Hemolysis: Further Considerations

Heenan¹,

Lunt

Chan³

et al. 2017

J Diabetes Sci Technol

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“…In this issue of the Journal of Diabetes Science and Technology , Heenan et al 1 compare 41 adults’ average capillary blood glucose meter (BGM) glucoses to their single central laboratory glucose (CLG) measurements of 0.6 mL lithium heparin plasma separator microtainers filled after “deep lancing” of the finger capillaries. The authors’ figure illustrates the relationship between the central laboratory instrument measurement of hemolysis (hemolysis index) and the ratios of the two sets of measurements.…”

mentioning

confidence: 99%

Deep Lancing or Overmanipulation?

Cembrowski

Füzéry

2017

J Diabetes Sci Technol

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Preanalytical Challenges During Capillary Fingerstick Sampling Preclude Its Widespread Use in Adult Hospitalized Patients

Jankowski

Casapao

Siller³

et al. 2020

American Journal of Clinical Pathology

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Objectives Patient compliance with laboratory testing is one of the most underrecognized challenges in developing a treatment plan for acute and chronically ill patients. The ability to offer alternatives to standard venipuncture blood draws would greatly increase a laboratory’s ability to provide testing to patients and health care providers. Methods We performed a prospective observational study on paired venous and fingerstick capillary blood samples from admitted patients undergoing vancomycin therapy. Paired specimens were analyzed for vancomycin and a basic metabolic panel (BMP: calcium, carbon dioxide, chloride, potassium, sodium, creatinine, glucose, serum urea nitrogen) on the core laboratory’s automated chemistry and immunochemistry platforms. Results A total of 59 paired fingerstick and venous blood specimens from 56 unique inpatients were analyzed. Paired samples were comparable for all the analytes tested with the exception of bicarbonate and potassium, which were significantly different among the capillary sample group. Patients required multiple fingers be lanced in 15% of cases to obtain sufficient blood to carry out the testing. Capillary sample rejection rates due to insufficient volumes were as high as 30% in the initial 30 patients enrolled in the study. Conclusions Vancomycin and the BMP, with the exception of potassium and bicarbonate, were determined to be analytically comparable. However, significant preanalytical issues should preclude laboratories and providers from more widespread adoption of fingerstick-derived capillary blood as an alternative sampling method except in the most extenuating of circumstances.

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How Much Hemolysis Is Acceptable When Undertaking Deep Lancing for Finger Stick Derived Capillary Plasma Glucose Measurement?

Cited by 5 publications

References 3 publications

Capillary Samples and Hemolysis: Further Considerations

Capillary Samples and Hemolysis: Further Considerations

Deep Lancing or Overmanipulation?

Preanalytical Challenges During Capillary Fingerstick Sampling Preclude Its Widespread Use in Adult Hospitalized Patients

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