How predictive learning influences choice: Evidence for a GPCR‐based memory process necessary for Pavlovian‐instrumental transfer

Laurent, Vincent; Balleine, Bernard W.

doi:10.1111/jnc.15339

Cited by 9 publications

(4 citation statements)

References 115 publications

(131 reference statements)

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“…This is consistent with neural studies that emphasize the critical role played by brain regions encoding and retrieving outcome-specific S–O associations in promoting specific PIT. For instance, it has been shown that the encoding of these associations in the basolateral amygdala (BLA) establishes a memory system that later allows these associations to control choice between actions during specific PIT (Laurent & Balleine, 2021; Morse et al, 2020). Further, other studies have shown that bidirectional connections between the BLA and the orbitofrontal cortex are necessary to encode and retrieve information about outcome-specific S–O associations to observe outcome-specific choice during a specific PIT test (Wassum, 2022).…”

Section: Discussionmentioning

confidence: 99%

Stimulus–outcome associations are required for the expression of specific Pavlovian-instrumental transfer.

Park,

Lingawi,

Crimmins

et al. 2024

Journal of Experimental Psychology: Animal Learning and Cogniti

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Section: Discussionmentioning

confidence: 99%

Stimulus–outcome associations are required for the expression of specific Pavlovian-instrumental transfer.

Park,

Lingawi,

Crimmins

et al. 2024

Journal of Experimental Psychology: Animal Learning and Cogniti

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“…Importantly, in the context obesity and potential deficits in NAc functioning, the core territory of the NAc (NAcC) mediates general PIT whereas its shell territory (NAcS) is required for specific PIT (Corbit, Fischbach, & Janak, 2016;Corbit, Muir, Balleine, & Balleine, 2001;Laurent, Leung, Maidment, & Balleine, 2012;Bertran-Gonzalez, Laurent, Chieng, Christie, & Balleine, 2013;Laurent, Bertran-Gonzalez, Chieng, & Balleine, 2014;Morse et al, 2020;Laurent & Balleine, 2021). Further, the metabolic .…”

Section: Introductionmentioning

confidence: 99%

High fat diet allows food-predictive stimuli to energize action performance in the absence of hunger, without distorting insulin signaling on accumbal cholinergic interneurons

Gladding

Lingawi

Leung

et al. 2023

Preprint

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Obesity can disrupt how food-predictive stimuli control action performance and selection. These two forms of control recruit cholinergic interneurons (CIN) located in the nucleus accumbens core (NAcC) and shell (NAcS), respectively. Given that obesity is associated with insulin resistance in this region, we examined whether interfering with CIN insulin signaling disrupts how food-predictive stimuli control actions. To interfere with insulin signaling we used a high-fat diet (HFD) or genetic excision of insulin receptor (InsR) from cholinergic cells. HFD left intact the capacity of food-predictive stimuli to energize performance of an action earning food when mice were tested hungry. However, it allowed this energizing effect to persist when the mice were tested sated. This persistence was linked to NAcC CIN activity but was not associated with distorted CIN insulin signaling. Accordingly, InsR excision had no effect on how food-predicting stimuli control action performance. Next, we found that neither HFD nor InsR excision altered the capacity of food-predictive stimuli to guide action selection. Yet, this capacity was associated with changes in NAcS CIN activity. These results indicate that insulin signaling on accumbal CIN does not modulate how food-predictive stimuli control action performance and selection. However, they show that HFD allows food-predictive stimuli to energize performance of an action earning food in the absence of hunger.

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“…Of these sources of predicted value, there have been several recent reviews of those controlling the influence of identity-specific reward predictions on instrumental performance, focussing mostly on their function in action selection in outcome-specific Pavlovian-instrumental transfer (Holmes et al, 2010 ; Cartoni et al, 2016 ; Watson et al, 2018 ; Balleine, 2019 ; Eder and Dignath, 2019 ; Laurent and Balleine, 2021 ). The current article is instead concerned with the contribution of general incentive processes to performance, i.e., those that induce their effects through a form of energetic shift in motivational or affective arousal.…”

Section: Introductionmentioning

confidence: 99%

The role of the bed nucleus of the stria terminalis in the motivational control of instrumental action

Balleine

2022

Front. Behav. Neurosci.

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We review recent studies assessing the role of the bed nucleus of the stria terminalis (BNST) in the motivational control of instrumental conditioning. This evidence suggests that the BNST and central nucleus of the amygdala (CeA) form a circuit that modulates the ventral tegmental area (VTA) input to the nucleus accumbens core (NAc core) to control the influence of Pavlovian cues on instrumental performance. In support of these claims, we found that activity in the oval region of BNST was increased by instrumental conditioning, as indexed by phosphorylated ERK activity (Experiment 1), but that this increase was not due to exposure to the instrumental contingency or to the instrumental outcome per se (Experiment 2). Instead, BNST activity was most significantly incremented in a test conducted when the instrumental outcome was anticipated but not delivered, suggesting a role for BNST in the motivational effects of anticipated outcomes on instrumental performance. To test this claim, we examined the effect of NMDA-induced cell body lesions of the BNST on general Pavlovian-to-instrumental transfer (Experiment 3). These lesions had no effect on instrumental performance or on conditioned responding during Pavlovian conditioning to either an excitory conditioned stimulus (CS) or a neutral CS (CS0) but significantly attenuated the excitatory effect of the Pavlovian CS on instrumental performance. These data are consistent with the claim that the BNST mediates the general excitatory influence of Pavlovian cues on instrumental performance and suggest BNST activity may be central to CeA-BNST modulation of a VTA-NAc core circuit in incentive motivation.

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How predictive learning influences choice: Evidence for a GPCR‐based memory process necessary for Pavlovian‐instrumental transfer

Cited by 9 publications

References 115 publications

Stimulus–outcome associations are required for the expression of specific Pavlovian-instrumental transfer.

Stimulus–outcome associations are required for the expression of specific Pavlovian-instrumental transfer.

High fat diet allows food-predictive stimuli to energize action performance in the absence of hunger, without distorting insulin signaling on accumbal cholinergic interneurons

The role of the bed nucleus of the stria terminalis in the motivational control of instrumental action

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