The economic impact caused by the outbreak and dynamic evolution of COVID-19 has reduced employees’ psychological security (PS), which not only threatens the physical and mental health of employees but also seriously affects the stable operation and sustainable development of enterprises. PS has been determined to be closely related to daily life experiences. Therefore, the purpose of this article is to examine the types and combinations of life events that improve employees’ PS during the pandemic. Cross-sectional data came from 764 enterprise employees in 8 provinces and cities in China during the pandemic period. The participants completed the PS scale to evaluate their PS, and the PS events scale to evaluate the different types of daily life events they experienced. Multiple regression analysis (MRA) and fuzzy-set qualitative comparative analysis (fsQCA) methods were used to test the research hypothesis. The results of MRA suggest that rich leisure activities (RLA), harmonious family relationship (HFR), stable economic order (SEO) and recognition and support from others (RSO) are important life events that enhance employees’ PS. The results of fsQCA suggest that the independent role of SEO, the combined role of sound social security system (SSSS), peace and health events (PHE) and HFR, the combined role of PHE, fulfilling work/life status (FWLS), SEO and RSO can substitute for each other to promote employees’ high PS. This article reveals the contribution of daily life events to the PS of enterprise employees, and provides an empirical basis for formulating corresponding intervention measures to promote the physical and mental health of enterprise employees and effective enterprise management.