Does the threat posed by the COVID-19 pandemic affect interpersonal trust? While most evidence shows that natural threats reinforce trust and cooperation, the COVID-19 virus differs from other calamities since it spreads through contact with people, thus potentially increasing mistrust and suspicion towards human beings. We in-vestigate the link between exposure to COVID-19 and trust in strangers by conducting a survey experiment with a representative sample of adults in Italy, one the countries that has been worst affected by the outbreak of the virus. Contrary to intuitive expectations, we find that those who report COVID-19 symptoms and those who live in the municipalities that have been worst affected by the virus trust strangers substantially more than their rela-tive counterparts. In addition, our experimental findings reveal that the risk that the COVID-19 pandemic poses to our health in the future leads to a substantial increase in trust in strangers. The risk that the pandemic poses to our livelihood, in terms of job loss and economic recession, also leads to a smaller increase in trust in strangers, while solidarity appeals and knowledge of people with COVID-19 symptoms within a close circle of relatives, friends and colleagues have no effects on trust. These findings, we suggest, could be explained by adapting the “emancipation theory of trust” to the context of natural disasters, conjecturing that when caught in catastrophes people become more dependent on other people’s support.