An emerging body of research has evidenced the negative in uence of using and being exposed to social networking sites (SNSs) on body image. Furthermore, it has been postulated that SNS use might be related with onset and persistence of eating disorders (EDs) psychopathology. The aim of the present study is to evaluate the complex interplay between Problematic Instagram use (PIU) (conceptualized as a potential behavioral addiction comprising withdrawal, con ict, tolerance, salience, mood modi cation and relapse) and ED psychopathology, by means of an explanatory Structural Equation Model. We hypothesized that PIU would be associated with ED symptoms through the mediating role of appearance comparison, individual psychological investment in physical appearance, and body uneasiness. A sample of 386 young female participants (M age = 26.04 ± 6.73) was recruited, of which 152 had received a diagnosis of ED. ED patients used Instagram more than the control group and showed higher levels of PIU. Results from structural equation modeling ( t indices: χ 2 = 44.54, df = 19, p < .001; RMSEA = .059; CFI = .98; SRMR = .02) showed that PIU predicted appearance comparison and psychological investment in physical appearance, which in turn predicted body uneasiness. In turn, body uneasiness predicted ED psychopathology and interpersonal di culties. Our model provides a useful account of how eating disorder symptoms could be triggered and maintained by an addictive use of Instagram.