How the stiffness of meniscal attachments and meniscal material properties affect tibio-femoral contact pressure computed using a validated finite element model of the human knee joint

Donahue, Tammy L. Haut; Hull, Maury L.; Rashid, Muhammad Mahbubur; Jacobs, Christopher R.

doi:10.1016/s0021-9290(02)00305-6

Cited by 225 publications

(213 citation statements)

References 53 publications

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“…A finite element simulation suggested some influence of this attachment on the contact mechanics of the knee. 31 Otherwise, little information is available on the significance of the peripheral attachments of the meniscus, which might therefore be of interest for future investigations.…”

Section: Discussionmentioning

confidence: 99%

Tensile forces at the porcine anterior meniscal horn attachment

Stärke

Kopf

Gröbel

et al. 2009

Journal Orthopaedic Research

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Tibiofemoral compression causes circumferential tension in the knee meniscus, which is transferred to the tibial bone at the anterior and posterior attachments. The objective of the study was to measure the resulting tensile forces at the horn attachment in a porcine model. The anterior horn attachment of the porcine medial meniscus (n ¼ 10) was separated from the surrounding bone with a core reamer. A force transducer was installed such that tensile forces acting upon the now mobile horn attachment could be measured. The tibiofemoral joint was loaded in compression, starting at a preload of 30 N, with three 150-N increments, giving 180, 330, and 480 N load. Flexion angles of 0, 30, and 608 were investigated. The average resultant tension at the horn attachment was 26.3, 40.6, and 55.4 N with full extension, 29.2, 47.8, and 62.2 N at 308 flexion and 30.1, 49.6, and 68.1 N at 608 flexion. The tibiofemoral compression had a significant effect on the tension (p < 0.001), whereas no influence of the flexion angle was found (p ¼ 0.291). The study demonstrates that tibiofemoral compressive loads cause considerable tensile forces at the anterior meniscal horn attachment. The data are of interest for models of the repair or replacement of the knee menisci. ß

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Section: Discussionmentioning

confidence: 99%

Tensile forces at the porcine anterior meniscal horn attachment

Stärke

Kopf

Gröbel

et al. 2009

Journal Orthopaedic Research

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“…Since meniscal attachments are important for meniscal function 5,12,24 the description of meniscal attachment microstructure and composition could prove beneficial in the development of tissue-engineered menisci. Not only is the external ligamentous portion and bony insertions important, but future studies should consider the transition from a triangular fibrocartilage in the main body of the meniscus, to the mostly rectangular external ligamentous portion of the attachment.…”

Section: Discussionmentioning

confidence: 99%

“…39 Previous experimental and theoretical studies have shown that meniscal attachment strength affects meniscal stability and function. 5,12,22,24 Anchoring the menisci at the anterior and posterior horns, the meniscal attachments are primarily composed of Type I collagen fibrils extending from the main body of the meniscus into the tibial plateau. 33 The attachments are often referred to as insertional ligaments.…”

Section: Introductionmentioning

confidence: 99%

A Quantitative Study of the Microstructure and Biochemistry of the Medial Meniscal Horn Attachments

Villegas

Hansen

Liu³

et al. 2007

Ann Biomed Eng

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Abstract-Little quantitative data is available on the structure of meniscal attachments. Therefore, as an aid to designing meniscal replacements as well as a possible explanation for mechanical behavior, this study was designed to further the knowledge of the microstructure and biochemistry of native meniscal attachments. Bovine medial meniscal attachments (the external ligamentous portion as well as the transition zones at the bony insertion) were removed and prepared for microstructural evaluation. After embedding in paraffin, the samples were sliced on a microtome and stained for quantitative analysis. The anterior and posterior insertion sites are known to contain three zones: subchondral bone, calcified fibrocartilage, and uncalcified fibrocartilage. Additionally, others have shown that the anterior insertion site contains a ligamentous zone. The insertion zones were further divided into proximal, middle, and distal zones. The posterior attachment's insertion site had a significantly greater thickness of interdigitations, subchondral bone, uncalcified fibrocartilage, and calcified fibrocartilage zone thickness compared to the anterior attachment insertion. The anterior attachment's insertion had the greatest GAG fraction in each zone when compared to the posterior attachment's insertion. GAG fraction decreased from the meniscus to the subchondral bone. Both GAG fraction and normalized thickness varied within a given zone, decreasing from the distal to proximal regions in both the anterior and posterior attachments' insertion zones. Crimp frequency of the collagen fibrils in the external ligamentous portion of the tissue was homogeneous along the length. The findings from this study agree with previously published material property data on the medial meniscal attachments, and could be used in the future to design methods of attachment for tissue engineered replacement menisci.

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“…Regarding their incorporation into meniscus substitutes, finite element models have shown that circumferential and axial/radial moduli are important determinants of the contact pressure distribution by the native meniscus and thus should ideally be matched in any replacement technology. 39 A significant advantage of synthetic scaffolds is the relative ease of manipulation of their biomechanical properties, whereas natural scaffolds may possess inherent advantages for cellular interaction. It has now also been shown that electrospun synthetic scaffolds (e.g., poly-E-caprolactone [PCL]) may provide an appropriate microarchitectural environment for meniscus cells.…”

Section: Biological Augmentation and Tissue Engineering Approaches Inmentioning

confidence: 99%