How the use of creatine supplements can elevate serum creatinine in the absence of underlying kidney pathology

Williamson, Lydia; New, David

doi:10.1136/bcr-2014-204754

Cited by 28 publications

(32 citation statements)

References 14 publications

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“…In addition to endogenous formation, creatinine may be taken up from cooked meat, as heating converts creatine to creatinine, and consumption of cooked meat may cause considerable temporary increases of serum creatinine (Jacobsen et al, 1979;Mayersohn et al, 1983;Nair et al, 2014;Pimenta et al, 2016). Also, creatine supplements, used in fitness training and bodybuilding, may be a cause of increased serum creatinine (Spillane et al, 2009;Velema and de Ronde, 2011;Williamson and New, 2014).…”

Section: Biomarkers For Function Of Renal Cation Transporters (Orgmentioning

confidence: 99%

Biomarkers for In Vivo Assessment of Transporter Function

Müller¹,

Sharma²,

König³

et al. 2018

Pharmacol Rev

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Drug-drug interactions are a major concern not only during clinical practice, but also in drug development. Due to limitations of in vitro-in vivo predictions of transporter-mediated drug-drug interactions, multiple clinical Phase I drug-drug interaction studies may become necessary for a new molecular entity to assess potential drug interaction liabilities. This is a resource-intensive process and exposes study participants, who frequently are healthy volunteers without benefit from study treatment, to the potential risks of a new drug in development. Therefore, there is currently a major interest in new approaches for better prediction of transporter-mediated drug-drug interactions. In particular, researchers in the field attempt to identify endogenous compounds as biomarkers for transporter function, such as hexadecanedioate, tetradecanedioate, coproporphyrins I and III, or glycochenodeoxycholate sulfate for hepatic uptake via organic anion transporting polypeptide 1B or N-methylnicotinamide for multidrug and toxin extrusion protein-mediated renal secretion. We summarize in this review the currently proposed biomarkers and potential limitations of the substances identified to date. Moreover, we suggest criteria based on current experiences, which may be used to assess the suitability of a biomarker for transporter function. Finally, further alternatives and supplemental approaches to classic drug-drug interaction studies are discussed.

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Section: Biomarkers For Function Of Renal Cation Transporters (Orgmentioning

confidence: 99%

Biomarkers for In Vivo Assessment of Transporter Function

Müller¹,

Sharma²,

König³

et al. 2018

Pharmacol Rev

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show abstract

“…CREA monohydrate is legally available and has been reported to be a safe supplement, without any adverse effects on the kidney and liver (35). However, serum creatinine levels were reported to be increased in certain individuals in the absence of a clinical cause of renal failure (36). In the present study, BUN and creatinine markers of kidney function were also analyzed.…”

Section: Discussionmentioning

confidence: 99%

Effects of bodybuilding and protein supplements in saliva, gingival crevicular fluid, and serum

et al. 2017

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, and bleeding on probing (BOP) were recorded. GI and BOP were higher in group BB-G and G than in group H (P < 0.01), but PI, PD, and CAL were similar between groups (P > 0.05). In GCF, CASP1, ASC, and IL-1β expression were upregulated in group G compared with groups BB-G and H (P < 0.01). In addition, ASC (P < 0.05) and IL-1β (P < 0.01) were downregulated in group BB-G compared with group H. CASP1, IL-1β (P < 0.01), and ASC in the saliva were downregulated in group BB-G compared with groups H and G (P < 0.05). CASP1, IL-1β, and ASC may play a role in the pathogenesis of gingivitis. Bodybuilding and supplement usage may decrease gingival inflammation by downregulating CASP1, IL-1β, and ASC.

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“…La CR es un ácido orgánico nitrogenado (C4H9N3O2) que proviene de dos fuentes: síntesis hepática (en menor medida renal y pancreática) mediante la utilización de 3 aminoácidos (arginina, glicina y metionina) y desde la dieta, por ingestión de carnes rojas y pescados 1,5,9,11 .…”

Section: Creatinaunclassified

“…El contenido de CR de un adulto de 70 kg es aproximadamente 120-140 g 5 . La producción hepática diaria es de alrededor de 2 g y la ingesta diaria con una dieta normal con carne es de 1 g 8,9,11 . El 95% se encuentra en los músculos y el resto en riñón, hígado, cerebro y testículos 1,5,11 .…”

Section: Creatinaunclassified

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Efectos en la función renal de la suplementación de creatina con fines deportivos

Vega

2019

Rev. méd. Chile

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Effects of creatine supplementation on renal function Creatine supplements may transitorily rise serum creatinine levels and mimic a kidney disease. If its use is associated with a high protein diet, the resulting increase in blood urea nitrogen will increase the confusion. Since clinical laboratories usually inform the estimated glomerular filtration rate based on serum creatinine, its elevation may lead to over diagnose a chronic renal failure, with the inherent personal and public health consequences. Creatine supplements are safe and do not cause renal disease. Reports of kidney damage associated with its use are scanty. However, creatine supplements should not be used in people with chronic renal disease or using potentially nephrotoxic medications.

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How the use of creatine supplements can elevate serum creatinine in the absence of underlying kidney pathology

Cited by 28 publications

References 14 publications

Biomarkers for In Vivo Assessment of Transporter Function

Biomarkers for In Vivo Assessment of Transporter Function

Effects of bodybuilding and protein supplements in saliva, gingival crevicular fluid, and serum

Efectos en la función renal de la suplementación de creatina con fines deportivos

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