How to improve the safety of adrenaline (epinephrine) autoinjectors

Kränke, Birger; Reiter, Harald; Kainz, Julius Thomas; Arbab, Emad

doi:10.1016/j.jaci.2011.02.009

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…15 Another suggestion that has been made is to change the order of steps for administration by placing the needle's end to the outer midthigh first, before removing the safety cap. 16 These could help reduce the contribution of a lack of proper training in the occurrence of autoinjector injuries, although this is yet to be further investigated. In an effort to reduce improper handling, design changes made to the EpiPen since its first introduction to the market included colorcoding both ends of the auto-injector by having a blue safety cap and an orange needle-end (Figure 1).…”

Section: Barriers and Preventative Strategiesmentioning

confidence: 99%

A Review of Auto-Injector Pen Safety and Preventative Strategies

2018

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Reports of auto-injector pen injuries have increased over the past decade. However, the true incidence of these injuries is unknown. We present the case of an accidental digital self-injection by a dermatologist whilst he was trying to administer the medication to a patient presenting with anaphylaxis as an example of a typical auto-injector injury. Additionally, we discuss safety issues, commonly reported injuries of accidental self-injection, and review the safety guidelines for use of a common auto-injector pen. Finally, we explore common barriers to proper auto-injector handling and suggested preventative strategies in order to decrease injuries caused by auto-injectors.

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Section: Barriers and Preventative Strategiesmentioning

confidence: 99%

A Review of Auto-Injector Pen Safety and Preventative Strategies

2018

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“…More attention is needed concerning not only education about prescribing and carrying self-injectable epinephrine but also when and how to use it, 63 which are common areas of mistakes. To improve safety and reduce the risk of injection into a thumb, Kranke et al 66 suggested that the injector be positioned on the body first, and then the final safety cap can be removed before applying pressure.…”

Section: Anaphylaxismentioning

confidence: 99%

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2011

Sicherer

Leung

2012

Journal of Allergy and Clinical Immunology

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This review highlights some of the research advances in anaphylaxis; hypersensitivity reactions to foods, drugs, and insects; and allergic skin diseases that were reported in the Journal in 2011. Food allergy appears to be increasing in prevalence and carries a strong economic burden. Risk factors can include dietary ones, such as deficiency of vitamin D and timing of complementary foods, and genetic factors, such as filaggrin loss-of-function mutations. Novel mechanisms underlying food allergy include the role of invariant natural killer T cells and influences of dietary components, such as isoflavones. Among numerous preclinical and clinical treatment studies, promising observations include the efficacy of sublingual and oral immunotherapy, a Chinese herbal remedy showing promising in vitro results, the potential immunotherapeutic effects of having children ingest foods with baked-in milk if they tolerate it, and the use of anti-IgE with or without concomitant immunotherapy. Studies of allergic skin diseases, anaphylaxis, and hypersensitivity to drugs and insect venom are elucidating cellular mechanisms, improved diagnostics, and potential targets for future treatment. The role of skin barrier abnormalities, as well as the modulatory effects of the innate and adaptive immune responses, are major areas of investigation.

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“…1a–c). We believe that training this sequence, with industry‐provided trainer devices, will prevent erroneous injections into hand and fingers in patients as well as caregivers (7).…”

mentioning

confidence: 99%